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Hemolytic-Uremic Syndrome (CUI C0019061) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0019061

NCI Thesaurus Code: C75545  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.

RADLEX Definition: Syndrome of hemolytic anemia, thrombocytopenia, and acute renal failure, with pathological finding of thrombotic microangiopathy in kidney and renal cortical necrosis. [MeSH]

GARD Definition: 

Hemolytic uremic syndrome (HUS) is a disorder that usually occurs when an  E. coli bacterial infection in the digestive system produces toxic substances that destroy red blood cells. Symptoms include vomiting and diarrhea, fever, lethargy, and weakness. In severe cases it can lead to kidney failure or death. While this condition is most common in children, it often has a more complicated presentation in adults. Treatment may include dialysis, corticosteroids, transfusions of packed red blood cells and plasmapheresis.   

Hemolytic uremic syndrome should be distinguished from atypical hemolytic uremic syndrome (aHUS). The two conditions have different causes and different signs and symptoms.

- this information is from GARD/ORDR/NCATS.

CTCAE Definition: A disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.

NICHD Definition: Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.

MSH Definition: A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.

Synonyms & Abbreviations: (see Synonym Details)
Acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells')
GASSER SYNDROME
Gasser's Syndrome
Gassers Syndrome
Hämolytisch-urämisches Syndrom
Haemolytic uraemic syndrome
Haemolytic-uraemic syndrome
Hemolytic uremic syndrome (disorder)
hemolytic uremic syndrome
Hemolytic uremic synd
Hemolytic-Uremic Syndrome [Disease/Finding]
HEMOLYTIC-UREMIC SYNDROME
HUS - Haemolytic uraemic syndrome
HUS - Hemolytic uremic syndrome
HUS
RENAL THROMBOTIC THROMBOCYTOPENIC PURPURA <HEMOLYTIC UREMIC SYNDROME>
Syndrome haemolytic uraemic
SYNDROME HEMOLYTIC UREMIC
Syndrome, Hemolytic-Uremic

External Source Codes: 
NCI Thesaurus Code C75545 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID D1113 SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0427-1005 CSP
DID 1682-2744 CSP
DISEASE_IDENTIFIER_ID 19027 GARD
DISEASE_IDENTIFIER_ID 19028 GARD
DX 19740101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 74(72) MSH
IAN DEFAULT ICD10
ICA Use additional code to identify associated: {E.coli infection (041.41-041.49); Pneumococcal pneumonia (481); Shigella dysenteriae (004.0)} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE. NDFRT
MESH_DUI D006463 NDFRT
MESH_NAME Hemolytic-Uremic Syndrome NDFRT
MESH_UI M0010145 NDFRT
MMR 20140613 MSH
MN C12.777.419.936.463 MSH
MN C13.351.968.419.936.463 MSH
MN C15.378.071.141.610 MSH
MN C15.378.140.855.925.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Hemolytic Uremic Syndrome NCI
NUI N0000001476 NDFRT
ORDER_NO 03407 ICD10CM
PM 74 MSH
PRIMARY_PATH 10018932$10002054$10018911$10005329$Haemolytic uraemic syndrome$Anaemias haemolytic mechanical factor$Haemolyses and related conditions$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6588/hemolytic-uremic-syndrome/resources/1 GARD
RXAUI 3164830 RXNORM
RXAUI 3164831 RXNORM
RXAUI 3171827 RXNORM
RXAUI 3171828 RXNORM
RXCUI 1024101 RXNORM
SMQ_TERM_ADDVERSION 13.0 MDR
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 8.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 13.0 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_LMVERSION 8.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 111407006 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D59.3 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D59.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D59.3 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CONGENITAL HEMOLYTIC UREMIC SYNDROME CHOOSE P78.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DIARRHEA-ASSOCIATED HEMOLYTIC UREMIC SYNDROME CHOOSE R19.7 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DIARRHEA-NEGATIVE HEMOLYTIC UREMIC SYNDROME CHOOSE P78.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF FAMILIAL HEMOLYTIC UREMIC SYNDROME CHOOSE D58.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HEMOLYTIC UREMIC SYNDROME OF CHILDHOOD CHOOSE P78.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF HEMOLYTIC UREMIC SYNDROME, ADULT TYPE CHOOSE P78.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 36568005 | Hemolytic uremic syndrome of childhood | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 373421000 | Diarrhea-associated hemolytic uremic syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 373422007 | Diarrhea-negative hemolytic uremic syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 444976001 | Congenital hemolytic uremic syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 722721004 | Familial hemolytic uremic syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 78209002 | Hemolytic uremic syndrome, adult type | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D58.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D59.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P78.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R19.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~D1113 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T019510 MSH
TERMUI T019511 MSH
TERMUI T019512 MSH
TH NLM (1972) MSH
TH NLM (1999) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code to identify associated: ICD10CM
USE_ADDITIONAL E. coli infection (B96.2-) ICD10CM
USE_ADDITIONAL Pneumococcal pneumonia (J13) ICD10CM
USE_ADDITIONAL Shigella dysenteriae (A03.9) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0019061

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