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Heart valve disease (CUI C0018824) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0018824

NCI Thesaurus Code: C45525  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Any heart disorder characterized by a defect in valve structure or function.

RADLEX Definition: Diseases caused by or resulting in abnormal functioning of heart valves. [MeSH]

MEDLINEPLUS Definition: 

Your heart has four valves. Normally, these valves open to let blood flow through or out of your heart, and then shut to keep it from flowing backward. But sometimes they don't work properly. If they don't, you could have

  • Regurgitation - when blood leaks back through the valve in the wrong direction
  • Mitral valve prolapse - when one of the valves, the mitral valve, has "floppy" flaps and doesn't close tightly. It's one of the most common heart valve conditions. Sometimes it causes regurgitation.
  • Stenosis - when the valve doesn't open enough and blocks blood flow

Valve problems can be present at birth or caused by infections, heart attacks, or heart disease or damage. The main sign of heart valve disease is an unusual heartbeat sound called a heart murmur. Your doctor can hear a heart murmur with a stethoscope. But many people have heart murmurs without having a problem. Heart tests can show if you have a heart valve disease. Some valve problems are minor and do not need treatment. Others might require medicine, medical procedures, or surgery to repair or replace the valve.

NIH: National Heart, Lung, and Blood Institute

CSP Definition: condition in which there is a deviation from or interruption of the normal functioning of heart valves.

MSH Definition: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Synonyms & Abbreviations: (see Synonym Details)
Cardiac valve disease
Cardiac valve disorders
cardiac valve disorder
Cardiac valvulopathy
Disease, Heart Valve
Disease, Valvular Heart
Diseases, Heart Valve
Diseases, Valvular Heart
Disorder of Heart Valve
Heart Disease, Valvular
Heart Diseases, Valvular
Heart Valve Diseases [Disease/Finding]
Heart Valve Diseases
Heart Valve Disease
Heart valve disorder (disorder)
Heart valve disorders
heart valve disorder
HEART VALVE DIS
Herzklappenerkrankung
Valve Disease, Heart
Valve Diseases, Heart
valve disease
Valvular heart disease NOS
Valvular Heart Diseases
valvular heart disease
Valvular Heart Disorder
Valvulopathy

External Source Codes: 
NCI Thesaurus Code C45525 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate IM with specific valve (IM) MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CITE Playbook RADLEX
Contributing_Source NICHD NCI
CTV3ID XaB0g SNOMEDCT_US
DATE_CREATED 08/20/1999 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 1393-3757 CSP
DX 19670101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HN 67; AORTIC VALVE DISEASES was heading 1963-66 MSH
MDA 19990101 MSH
MESH_DEFINITION Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE). NDFRT
MESH_DUI D006349 NDFRT
MESH_NAME Heart Valve Diseases NDFRT
MESH_UI M0009972 NDFRT
MMR 20070709 MSH
MN C14.280.484 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/heartvalvediseases.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/heartvalvediseases.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Valvular Heart Disorder NCI
NUI N0000001443 NDFRT
OL use HEART VALVE DISEASES to search AORTIC VALVE DISEASES 1966 MSH
PM 67; AORTIC VALVE DISEASES was heading 1963-66 MSH
PRIMARY_PATH 10061406$10046971$10046973$10007541$Cardiac valve disease$Cardiac valve disorders NEC$Cardiac valve disorders$Cardiac disorders MDR
PRIMARY_SOC 10007541 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3171253 RXNORM
RXAUI 3171254 RXNORM
RXAUI 3254632 RXNORM
RXCUI 989613 RXNORM
SNOMED_CID 368009 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS I38 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~I38 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS I38 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I38 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XaB0g SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T019238 MSH
TERMUI T426394 MSH
TH NLM (1967) MSH
TH NLM (2002) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0018824

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