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Guillain-Barre Syndrome (CUI C0018378) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0018378

NCI Thesaurus Code: C116345  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A rapidly progressive autoimmune disorder of the peripheral nervous system characterized by limb paresthesias, areflexia, and generalized muscle weakness or paralysis that often begins in the legs and spreads to the arms, torso, and face.

RADLEX Definition: An acute inflammatory autoimmune neuritis caused by T cell-mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314) [MeSH]

GARD Definition: Guillain-Barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. Symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. Usually Guillain-Barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. It remains unclear why only some people develop Guillain-Barre syndrome. Most patients recover completely, although some continue to have some degree of weakness. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Guillain-Barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (PNS). The PNS nerves connect your brain and spinal cord with the rest of your body. Damage to these nerves makes it hard for them to transmit signals. As a result, your muscles have trouble responding to your brain. No one knows what causes the syndrome. Sometimes it is triggered by an infection, surgery, or a vaccination.

The first symptom is usually weakness or a tingling feeling in your legs. The feeling can spread to your upper body. In severe cases, you become almost paralyzed. This is life-threatening. You might need a respirator to breathe. Symptoms usually worsen over a period of weeks and then stabilize.

Guillain-Barre can be hard to diagnose. Possible tests include nerve tests and a spinal tap. Most people recover. Recovery can take a few weeks to a few years. Treatment can help symptoms, and may include medicines or a procedure called plasma exchange.

NIH: National Institute of Neurological Disorders and Stroke

NICHD Definition: A progressive autoimmune disorder of the peripheral nervous system characterized by respiratory insufficiency, limb paresthesias, areflexia, and generalized muscle weakness or paralysis that often begins in the legs and spreads to the arms, torso, and face.

CSP Definition: progressive ascending motor neuron paralysis of unknown etiology, frequently following an enteric or respiratory infection.

MSH Definition: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)

Synonyms & Abbreviations: (see Synonym Details)
Acute (post-)infective polyneuritis
Acute Autoimmune Neuropathies
Acute Autoimmune Neuropathy
Acute autoimmune peripheral neuropathy
Acute idiopathic demyelinating polyneuropathy
Acute idiopathic polyneuritis
Acute idiopathic polyradiculoneuritis
Acute immune-mediated polyneuropathy
ACUTE INFLAMM POLYNEUROPATHY
ACUTE INFLAMM POLYRADICULONEUROPATHY
acute inflammatory demyelinating polyradiculoneuropathy
Acute inflammatory neuropathy
Acute Inflammatory Polyneuropathies
Acute inflammatory polyneuropathy
Acute Inflammatory Polyradiculoneuropathies
Acute Inflammatory Polyradiculoneuropathy
Acute polyradiculoneuritis
Acute post-infective radiculoneuropathy
Acute, Inflammatory Polyneuropathy
Ascending paralysis
Autoimmune Neuropathies, Acute
Autoimmune Neuropathy, Acute
GBS
GUILLAIN BARRE DISEASE
Guillain Barre Syndrome
Guillain Barré Syndrome
GUILLAIN-BARRE DISEASE
Guillain-Barre Syndrome [Disease/Finding]
Guillain-Barre syndrome
Guillain-Barre Syndrom
Guillain-Barré syndrome
Guillain-Barré-Strohl syndrome
Guillain-Barré syndrome (disorder)
Guillain-Barré syndrome
Guillaine Barre Syndrome
Guillaine-Barre Syndrome
GULLIAN BARRE SYNDROME
INFLAMM POLYNEUROPATHY ACUTE
Inflammatory Polyneuropathies, Acute
Inflammatory Polyneuropathy Acutes
Inflammatory Polyneuropathy Acute
Inflammatory Polyneuropathy, Acute
Inflammatory Polyradiculoneuropathies, Acute
Landry Guillain Barre Syndrome
LANDRY PARALYSIS
Landry's ascending paralysis
Landry's paralysis
Landry-Guillain-Barre syndrome
Landry-Guillain-Barre-Strohl syndrome
Landry-Guillain-Barré syndrome
Neuropathies, Acute Autoimmune
Neuropathy, Acute Autoimmune
Paralysis ascending
Polyneuropathies, Acute Inflammatory
POLYNEUROPATHY ACUTE INFLAMM
Polyneuropathy Acute, Inflammatory
Polyneuropathy, Acute Inflammatory
Polyradiculoneuropathies, Acute Inflammatory
POLYRADICULONEUROPATHY ACUTE INFLAMM
Polyradiculoneuropathy, Acute Inflammatory
Post-infectious polyneuritis (disorder)
Post-infectious polyneuritis
Post-infective polyneuritis
SYNDROME GUILLAIN-BARRE
Syndrome, Guillain-Barre
Syndrome, Guillaine-Barre
Syndrome, Landry-Guillain-Barre

External Source Codes: 
NCI Thesaurus Code C116345 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse X ref POLYRADICULONEUROPATHY, ACUTE INFLAMMATORY with POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY see POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID F3700 SNOMEDCT_US
CTV3ID F3701 SNOMEDCT_US
DATE_CREATED 06/28/2000 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2042-6653 CSP
DISEASE_IDENTIFIER_ID 18933 GARD
DISEASE_IDENTIFIER_ID 18934 GARD
DISEASE_IDENTIFIER_ID 18935 GARD
DISEASE_IDENTIFIER_ID 18938 GARD
DISEASE_IDENTIFIER_ID 18939 GARD
DISEASE_IDENTIFIER_ID 18940 GARD
DISEASE_IDENTIFIER_ID 18941 GARD
DISEASE_IDENTIFIER_ID 18942 GARD
DISEASE_IDENTIFIER_ID 31325 GARD
DISEASE_IDENTIFIER_ID 31326 GARD
DISEASE_IDENTIFIER_ID 34830 GARD
DX 20000101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 2000; use POLYRADICULONEUROPATHY 1979-1999 MSH
IAN DEFAULT ICD10
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Acute (post-)infective polyneuritis ICD10
INCLUSION_TERM Miller Fisher Syndrome ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-10-19T00:00:00 GARD
MDA 19991103 MSH
MESH_DEFINITION An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314) NDFRT
MESH_DUI D020275 NDFRT
MESH_NAME Guillain-Barre Syndrome NDFRT
MESH_UI M0017242 NDFRT
MMR 20130708 MSH
MN C10.114.750.100 MSH
MN C10.314.750.450 MSH
MN C10.668.829.350 MSH
MN C10.668.829.800.750.300 MSH
MN C20.111.258.750.400 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/guillainbarresyndrome.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/guillainbarresyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Guillain-Barre Syndrome NCI
NUI N0000004093 NDFRT
ORDER_NO 06328 ICD10CM
PM 2000; see POLYRADICULONEURITIS 1979-1999 MSH
PRIMARY_PATH 10018767$10001014$10034606$10029205$Guillain-Barre syndrome$Acute polyneuropathies$Peripheral neuropathies$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6554/guillain-barre-syndrome/resources/1 GARD
RXAUI 3105963 RXNORM
RXAUI 3106000 RXNORM
RXAUI 3106002 RXNORM
RXAUI 3167383 RXNORM
RXAUI 3167384 RXNORM
RXAUI 3167387 RXNORM
RXAUI 3181069 RXNORM
RXAUI 3188139 RXNORM
RXAUI 3222266 RXNORM
RXAUI 3222387 RXNORM
RXAUI 5931054 RXNORM
RXCUI 1022872 RXNORM
RXCUI 1748640 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 11.0 MDR
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_ADDVERSION 8.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 11.0 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_LMVERSION 8.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 128085000 NDFRT
SNOMED_CID 129131007 NDFRT
SNOMED_CID 193174005 NDFRT
SNOMED_CID 40956001 NDFRT
SNOMEDID DA-00A9A SNOMEDCT_US
SNOMEDID DE-A1300 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G61.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G61.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G61.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G61.0 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F3700 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F3701 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-00A9A SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DE-A1300 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T032746 MSH
TERMUI T368418 MSH
TERMUI T368420 MSH
TERMUI T368422 MSH
TERMUI T368423 MSH
TERMUI T368424 MSH
TERMUI T368426 MSH
TERMUI T368428 MSH
TERMUI T368430 MSH
TERMUI T841557 MSH
TH GHR (2014) MSH
TH NLM (2000) MSH
TH NLM (2014) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0018378

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