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Glycine (CUI C0017890) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017890

NCI Thesaurus Code: C524  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Pharmacologic Substance

Semantic Type: Amino Acid, Peptide, or Protein

NCIt Definition: A non-essential, non-polar, non-optical, glucogenic amino acid. Glycine, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is an important component and precursor for many macromolecules in the cells.

PDQ Definition: A non-essential, non-polar, non-optical, glucogenic amino acid. Glycine, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is an important component and precursor for many macromolecules in the cells. Check for active clinical trials using this agent. (NCI Thesaurus)

CRCH Definition: Amino acid with side chain -H.

CSP Definition: non-essential amino acid; found primarily in gelatin and silk fibroin and used therapeutically as a nutrient; it is also a fast inhibitory neurotransmitter.

MSH Definition: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

NPO Definition: An alpha-aminoacid with chemical formula NH2-CH2-C(OH)=OH.

Synonyms & Abbreviations: (see Synonym Details)
2-aminoacetic acid
25936
56-40-6
Acid, Aminoacetic
Aminoacetic acid
Aminoessigsaeure
Aminoethanoic acid
Gln
Glycine (substance)
Glycine - amino acid
Glycine [Chemical/Ingredient]
glycine
Glycin
Glycocoll
Glykokoll
Glyzin
Gly
G
H2N-CH2-COOH
Hgly
Product containing glycine (medicinal product)
Product containing glycine

External Source Codes: 
NCI Thesaurus Code C524 (see NCI Thesaurus info)
CAS Registry Number 56-40-6 (see NLM ChemIDplus info)
FDA UNII Code TE7660XO1C
NSC Code 25936 (see NCI DTP info)
PDQ Closed Trial Search ID 41347
PDQ Open Trial Search ID 41347 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Rosse MD FMA
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15428 NCI
Chemical_Formula C2H5NO2 NCI
CODE NPO_800 NPO
Contributing_Source CRCH NCI
Contributing_Source FDA NCI
CTV3ID x005A SNOMEDCT_US
CTV3ID XM0lj SNOMEDCT_US
DATE_LAST_MODIFIED 2008-10-15 PDQ
DB_XR_ID CHEBI:15428 NPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0124-2520 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE TE7660XO1C DRUGBANK
FDA_UNII_CODE TE7660XO1C NDFRT
FX D018009 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. NDFRT
MESH_DUI D005998 NDFRT
MESH_NAME Glycine NDFRT
MESH_UI M0009451 NDFRT
MMR 20130708 MSH
MN D12.125.481 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C524 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006576 NDFRT
NUI N0000146327 NDFRT
ORIG_STY Drug/agent PDQ
PA D018684 MSH
PID 4419 PDQ
RDF_ID CHEBI_15428 NPO
RN TE7660XO1C MSH
RR 15743-44-9 (mono-K salt) MSH
RR 17829-66-2 (Co salt) MSH
RR 1KIB230SGR MSH
RR 225ZLC74HX MSH
RR 29728-27-6 (monoammonium salt) MSH
RR 32817-15-5 (Cu salt) MSH
RR 33242-26-1 (Ca salt) MSH
RR 35947-07-0 (Ca salt (2:1)) MSH
RR 50610-34-9 (carbonate (2:1), mono-Na salt) MSH
RR 50610-35-0 (carbonate (2:1), mono-K salt) MSH
RR 50794-29-1 (carbonate (2:1), mono-Li salt) MSH
RR 513-29-1 (sulfate (3:1)) MSH
RR 56-40-6 (Glycine) MSH
RR 567R60Z85R MSH
RR 6000-43-7 (HCl) MSH
RR 6000-44-8 (mono-Na salt) MSH
RR 63183-41-5 (Na hydrogen carbonate) MSH
RR 66630-62-4 (carbonate (1:1), mono-Na salt) MSH
RR 71295-98-2 (phosphate (1:1)) MSH
RR 7490-95-1 (HCl (2:1)) MSH
RR 75194-99-9 (phosphate) MSH
RR F6B979BV8Z MSH
RXAUI 150737 RXNORM
RXAUI 2071246 RXNORM
RXAUI 2597144 RXNORM
RXAUI 3041485 RXNORM
RXAUI 3092692 RXNORM
RXAUI 3108284 RXNORM
RXAUI 3163573 RXNORM
RXAUI 3163574 RXNORM
RXAUI 3166252 RXNORM
RXAUI 3166304 RXNORM
RXAUI 4238519 RXNORM
RXAUI 4238520 RXNORM
RXCUI 4919 RXNORM
SID NUTR00028 DRUGBANK
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SPL_SET_ID ffebf88b-d257-4542-9808-74d9b7167765 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x005A SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0lj SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T018220 MSH
TERMUI T018221 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^577^Active/Master NDFRT
VANDF_RECORD 50.6^1045^Active/Master NDFRT
VUID 4017980 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017890

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