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Nitroglycerin (CUI C0017887) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017887

NCI Thesaurus Code: C29294  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerine causes coronary artery dilatation, thereby improving myocardial blood distribution.

PDQ Definition: An organic nitrate with vasodilator activity. Nitroglycerin is converted into nitric oxide (NO) in smooth muscle and activates guanylyl cyclase, thereby increasing cGMP concentration, and resulting in smooth muscle relaxation. Dilatation of the veins results in decreased venous return to the heart, thereby decreasing left ventricular volume (reduced preload) and decreasing myocardial oxygen requirements. Arteriolar relaxation reduces arteriolar resistance (reduced afterload), thereby decreasing myocardial oxygen demands. In addition, nitroglycerin causes coronary artery dilatation, thereby improving myocardial blood distribution. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: In medicine, a substance used as a drug to treat certain heart conditions and to widen the openings in blood vessels. Nitroglycerin is being studied as a way to help chemotherapy work better by making tumor cells more sensitive to the drugs. It is a type of vasodilator.

CSP Definition: volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium; an explosive compound rendered safe when compounded in tablets with mannitol.

MSH Definition: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.

Synonyms & Abbreviations: (see Synonym Details)
1,2,3-propanetriol trinitrate
1,2,3-Propanetriol, trinitrate
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
55-63-0
Glycerin trinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitrat
Glyceryl trinitrate (substance)
glyceryl trinitrate
NG
Nitroglicerina
Nitroglycerin [Chemical/Ingredient]
nitroglycerine
nitroglycerin
Nitroglycerol
Product containing glyceryl trinitrate (medicinal product)
Product containing glyceryl trinitrate
Product containing nitroglycerin
Propane-1,2,3-triyl trinitrate
Rectiv
Trinitrate, Glyceryl
Trinitrine
Trinitroglycerin
Trinitroglycerol

External Source Codes: 
NCI Thesaurus Code C29294 (see NCI Thesaurus info)
CAS Registry Number 55-63-0 (see NLM ChemIDplus info)
FDA UNII Code G59M7S0WS3
PDQ Closed Trial Search ID 587505
PDQ Open Trial Search ID 587505 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Anal Fissure and Fistula NCI
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:28787 NCI
Chemical_Formula C3H5N3O9 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID bl1.. SNOMEDCT_US
CTV3ID XUWvo SNOMEDCT_US
DATE_FIRST_PUBLISHED 2008-02-13 PDQ
DATE_LAST_MODIFIED 2008-02-11 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2997-4864 CSP
DX 19920101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE G59M7S0WS3 DRUGBANK
FDA_UNII_CODE G59M7S0WS3 NDFRT
FX D009574 MSH
FX D020030 MSH
HN 92; was GLYCERYL TRINITRATE 1963-91; NITROGLYCERIN was see GLYCERYL TRINITRATE 1963-91 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MTH
MDA 19990101 MSH
MESH_DEFINITION A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. NDFRT
MESH_DUI D005996 NDFRT
MESH_NAME Nitroglycerin NDFRT
MESH_UI M0009426 NDFRT
MMR 20130708 MSH
MN D02.033.800.421.560 MSH
MN D02.640.636 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C29294 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006574 NDFRT
NUI N0000145909 NDFRT
OL use NITROGLYCERIN to search GLYCERYL TRINITRATE 1966-91 MSH
ORIG_STY Drug/agent PDQ
PA D014665 MSH
PA D053834 MSH
PM 92; was GLYCERYL TRINITRATE 1963-91; NITROGLYCERIN was see GLYCERYL TRINITRATE 1963-91 MSH
RN G59M7S0WS3 MSH
RR 55-63-0 (Nitroglycerin) MSH
RXAUI 150615 RXNORM
RXAUI 2072553 RXNORM
RXAUI 2597752 RXNORM
RXAUI 2600083 RXNORM
RXAUI 2655559 RXNORM
RXAUI 3091047 RXNORM
RXAUI 3166246 RXNORM
RXAUI 3203330 RXNORM
RXAUI 3203331 RXNORM
RXAUI 3207158 RXNORM
RXAUI 3207159 RXNORM
RXAUI 3745105 RXNORM
RXCUI 1114467 RXNORM
RXCUI 4917 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00153 DRUGBANK
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SPL_SET_ID efb1e4fc-73b8-43c5-ac68-d5b870cc8e10 MTHSPL
SPL_SET_ID f0714208-794d-4669-abc4-a6a6ee56be87 MTHSPL
SPL_SET_ID f21824ed-9346-e69e-983e-7bdf172b9f0d MTHSPL
SPL_SET_ID f28fc049-5cd1-4836-8ff7-d806de9ca866 MTHSPL
SPL_SET_ID f3dd8457-7b38-44ca-a1a9-60e14d445467 MTHSPL
SPL_SET_ID f76d4389-dd27-ca13-dc55-e41dcfa2f72b MTHSPL
SPL_SET_ID F9EB07A2-5EBC-40EA-9890-1A0B03E859FF MTHSPL
SPL_SET_ID fa741a42-a7b5-477e-8407-defd88e38325 MTHSPL
SPL_SET_ID fb5746d5-5dca-40ea-866f-fb4ee0570916 MTHSPL
SPL_SET_ID fbaddc57-5de4-421d-8590-748768ec87d7 MTHSPL
SPL_SET_ID fbb68ef0-6652-435e-8a2c-512bdc7653e2 MTHSPL
SPL_SET_ID fc42ed60-8d33-08ae-434c-741ae3e19cc2 MTHSPL
SPL_SET_ID fc70e584-55e4-4b32-9372-1ee1601f6635 MTHSPL
SPL_SET_ID fcd4cf8a-e3e6-7da9-6355-c60b7400291a MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~bl1.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWvo SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T018188 MSH
TERMUI T018189 MSH
TH FDA SRS (2014) MSH
TH NLM (1992) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^117^Active/Master NDFRT
VANDF_RECORD 50.6^68^Active/Master NDFRT
VUID 4017525 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017887

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