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Glutathione (CUI C0017817) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017817

NCI Thesaurus Code: C523  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Amino Acid, Peptide, or Protein

NCIt Definition: A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.

PDQ Definition: A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A substance found in plant and animal tissues that has many functions in a cell. These include activating certain enzymes and destroying toxic compounds and chemicals that contain oxygen.

CSP Definition: tripeptide composed of gamma-glutamate, cysteine, and glycine; an important endogenous reducing agent involved in oxidative respiration and free radical scavenging.

MSH Definition: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Synonyms & Abbreviations: (see Synonym Details)
400639
5-L-Glutamyl-L-cysteinylglycine
70-18-8
gamma L Glu L Cys Gly
gamma L Glutamyl L Cysteinylglycine
gamma-L-Glu-L-Cys-Gly
gamma-L-Glutamyl-L-cysteinyl-glycine
gamma-L-Glutamyl-L-Cysteinylglycine
Glutathione (product)
Glutathione (substance)
Glutathione [Chemical/Ingredient]
Glutathione-SH
glutathione
Glutham
Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
GSH
N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
N-(N-L-gamma-glutamyl-L-cysteinyl)glycine
Reduced Glutathione
TAD

External Source Codes: 
NCI Thesaurus Code C523 (see NCI Thesaurus info)
CAS Registry Number 70-18-8 (see NLM ChemIDplus info)
FDA UNII Code GAN16C9B8O
NSC Code 400639 (see NCI DTP info)
PDQ Closed Trial Search ID 655232
PDQ Open Trial Search ID 655232 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:16856 NCI
Chemical_Formula C10H17N3O6S NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUecE SNOMEDCT_US
CTV3ID XUGOC SNOMEDCT_US
DATE_FIRST_PUBLISHED 2009-09-15 PDQ
DATE_LAST_MODIFIED 2009-09-15 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2237-5409 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20070131 SNOMEDCT_US
FDA_UNII_CODE GAN16C9B8O DRUGBANK
FDA_UNII_CODE GAN16C9B8O NDFRT
LEVEL Ingredient NDFRT
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. NDFRT
MESH_DUI D005978 NDFRT
MESH_NAME Glutathione NDFRT
MESH_UI M0009388 NDFRT
MMR 20130708 MSH
MN D12.644.456.448 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C523 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006503 NDFRT
NUI N0000148266 NDFRT
ORIG_STY Drug/agent PDQ
RN GAN16C9B8O MSH
RR 70-18-8 (Glutathione) MSH
RXAUI 149879 RXNORM
RXAUI 2071226 RXNORM
RXAUI 3163319 RXNORM
RXAUI 3163320 RXNORM
RXAUI 3166113 RXNORM
RXAUI 3166142 RXNORM
RXAUI 3166318 RXNORM
RXAUI 3260701 RXNORM
RXAUI 3260702 RXNORM
RXAUI 3631611 RXNORM
RXAUI 6395449 RXNORM
RXCUI 4890 RXNORM
SID EXPT01650 DRUGBANK
SID NUTR00029 DRUGBANK
SPL_SET_ID 0423ac87-109c-45f6-aaaf-8473cc197e35 MTHSPL
SPL_SET_ID 06b3137f-15cb-4d30-8741-12f6231e8402 MTHSPL
SPL_SET_ID 1082fb92-5986-4960-8d60-508e07ba9f78 MTHSPL
SPL_SET_ID 138538b8-e97e-4aed-bb6e-1df22e028501 MTHSPL
SPL_SET_ID 1b732734-2492-45c4-97a8-50aa98be8980 MTHSPL
SPL_SET_ID 1efd5bfa-9c9b-4732-948f-ae786f3e0f9c MTHSPL
SPL_SET_ID 26089538-c122-4a4a-b47f-8f7f7586748f MTHSPL
SPL_SET_ID 28e0dfa0-9cda-436b-89bf-043d7baf2efe MTHSPL
SPL_SET_ID 29b660c9-d32c-335d-e054-00144ff8d46c MTHSPL
SPL_SET_ID 29b7a7bb-08da-739f-e054-00144ff8d46c MTHSPL
SPL_SET_ID 29c7a4fc-6606-509f-e054-00144ff88e88 MTHSPL
SPL_SET_ID 29c89b90-0d45-70f9-e054-00144ff88e88 MTHSPL
SPL_SET_ID 33d8ecac-2bb9-44b5-8016-3bb37db38eb5 MTHSPL
SPL_SET_ID 35b3e886-bc74-4078-8ee3-d7b24598754c MTHSPL
SPL_SET_ID 35f22641-b925-480b-9dd3-b1c91181648c MTHSPL
SPL_SET_ID 3a369e12-984c-4b94-9b77-eb8d77c545bb MTHSPL
SPL_SET_ID 4a977b8f-d2aa-49fc-9322-32d38bc3f08a MTHSPL
SPL_SET_ID 4d28d68d-0793-4f45-9dbf-ce38cede000c MTHSPL
SPL_SET_ID 56a0820a-5f10-4e31-ac67-4ecec164b733 MTHSPL
SPL_SET_ID 590eb79f-902a-427a-8b17-f7bd06e6a34f MTHSPL
SPL_SET_ID 5ac221ea-6de7-4358-bb62-6d24ff74d4b9 MTHSPL
SPL_SET_ID 5b76948a-f87a-443c-b839-077fc4fffd09 MTHSPL
SPL_SET_ID 5c37806e-a3f4-40b9-bdb6-5886ef85f736 MTHSPL
SPL_SET_ID 619a3a3f-039e-437f-b734-2f6dd280c029 MTHSPL
SPL_SET_ID 6a4ddb57-52db-4b90-bfbc-2e30345e08a5 MTHSPL
SPL_SET_ID 7f1422b6-4cd0-4666-8d43-5090418ec27b MTHSPL
SPL_SET_ID 80fa03d2-cd4c-4155-9b57-1396c4fa42da MTHSPL
SPL_SET_ID 8db8dcb5-a50e-4e5d-ba37-26f83107e199 MTHSPL
SPL_SET_ID 9110b270-b3c7-4069-9c17-50cb4cfbe739 MTHSPL
SPL_SET_ID 91ca765f-fe58-4dee-a7eb-c8d3de9f115a MTHSPL
SPL_SET_ID 98f62400-190d-4f7f-aedc-c7e28d98a21a MTHSPL
SPL_SET_ID 9a378977-7178-4dd9-8524-13e6cad77a8d MTHSPL
SPL_SET_ID b0bf5462-bd6f-4233-aa03-344532f94271 MTHSPL
SPL_SET_ID ba1e618b-589f-4151-9e84-716a50ec8c2a MTHSPL
SPL_SET_ID bb843118-ef62-4362-a7d0-f10b5f6cd132 MTHSPL
SPL_SET_ID bbbd8cca-f746-4d68-bcef-f44b4ac44b97 MTHSPL
SPL_SET_ID c1cb5366-e5d4-488e-947f-c30e0e2c6936 MTHSPL
SPL_SET_ID c6a1c79a-2dda-479c-8ec1-c9cade6d451b MTHSPL
SPL_SET_ID cbce515e-cc38-465c-bd56-142a49f0792e MTHSPL
SPL_SET_ID ce25f3c5-20c9-4ba8-ac58-546febf142ec MTHSPL
SPL_SET_ID ceb9c32f-4cca-405e-b2c1-0fce38504a45 MTHSPL
SPL_SET_ID cf95e472-6d9b-448e-acdb-2f2fffc2bb3c MTHSPL
SPL_SET_ID d722004e-649d-49dc-adec-f8f17049c4b5 MTHSPL
SPL_SET_ID d81fb1a9-c07c-4137-8ee5-a112b909099e MTHSPL
SPL_SET_ID d93a8991-bf69-956a-21fc-dac24955ee42 MTHSPL
SPL_SET_ID dbf8e1b6-453e-43a2-ae64-d51421b4da46 MTHSPL
SPL_SET_ID dd344e09-ab4d-4b36-9812-06388826bd5f MTHSPL
SPL_SET_ID e9df51c5-d681-496b-b1ef-3c4e7b84be29 MTHSPL
SPL_SET_ID eb4e343b-dbc8-43d3-93aa-042869de090c MTHSPL
SPL_SET_ID eb67ee2f-a71b-4c76-a0b8-c7e904061003 MTHSPL
SPL_SET_ID ec58fc34-8c63-489c-8ae0-1b9998c5cad7 MTHSPL
SPL_SET_ID f1e9d63e-c3a3-4dcb-beea-65e84b5b79c0 MTHSPL
SPL_SET_ID f5c6a7a2-ec5a-43b0-b819-263ebad66cfe MTHSPL
SPL_SET_ID f69655c5-cf32-6461-e00e-3a5c4a761344 MTHSPL
SPL_SET_ID f87904f9-d115-4e71-bb0a-210c0bc6918a MTHSPL
SPL_SET_ID fadfbb61-6c66-4fcb-80c4-0fb35ae9978b MTHSPL
SPL_SET_ID fee71618-533b-41c8-bbdd-0a7ff68509b8 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUecE SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUGOC SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T018113 MSH
TERMUI T018114 MSH
TERMUI T018115 MSH
TH FDA SRS (2014) MSH
TH JAN (19XX) MSH
TH NLM (1966) MSH
TH NLM (1998) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3208^Active/Master NDFRT
VUID 4020562 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017817

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