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Immunoglobulin A Nephropathy (CUI C0017661) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017661

NCI Thesaurus Code: C34643  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A chronic autoimmune glomerulonephritis characterized by the deposition of immunoglobulin A in the mesangium of the glomeruli. It is manifested with hematuria and mild proteinuria.

GARD Definition: Berger disease (frequently called IgA nephropathy) is a kidney disorder that occurs when IgA, a protein that helps the body fight infections, settles in the kidneys. The cause of this condition is unknown. After many years, deposits of IgA may cause the kidneys to leak blood and sometimes protein in the urine. In the early stages, Berger disease has no symptoms. The first sign of this condition may be blood in the urine. After 10 to 20 years with Berger disease, the kidneys may show signs of damage. Treatment focuses on slowing the disease and preventing complications.

Berger disease can occur at any age, even in childhood. About 25 percent of adults and 5 to 10 percent of children with Berger disease develop total kidney failure. Total kidney failure means the kidney damage is permanent and dialysis or a kidney transplant is required.   - this information is from GARD/ORDR/NCATS.

NICHD Definition: Glomerulonephropathy characterized by mesangial deposition of IgA antibody in the glomerulus. It is often characterized by hematuria, which may include episodes of visible hematuria during acute illness, and/or proteinuria.

CSP Definition: most common cause of primary glomerular disease in Europe, Australia, and United States; lesions formed as a consequence of mesangial formations of immune deposits composed of IgA.

MSH Definition: A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.

Synonyms & Abbreviations: (see Synonym Details)
BERGER DISEASE
BERGER DIS
Berger's Disease
Bergers disease
BERGERS DIS
Focal glomerulonephritis
Glomerulonephritides, IGA
GLOMERULONEPHRITIS FOCAL
Glomerulonephritis, IGA [Disease/Finding]
Glomerulonephritis, IGA
IDIOPATHIC FOCAL NEPHRITIS WITH MESANGIAL DEPOSITS OF IGA
IGA Glomerulonephritis
Iga Nephropathy 1
IgA nephropathy
IGA Type Nephritis
IgAN - IgA nephropathy
IGAN
Immunoglobulin A nephropathy (disorder)
Immunoglobulin A Nephropathy
Nephritis, IGA type
Nephropathy 1, Iga
NEPHROPATHY, IGA
Nephropathy, Immunoglobulin A

External Source Codes: 
NCI Thesaurus Code C34643 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse X ref BERGER'S DISEASE with BUERGER'S DISEASE see THROMBOANGIITIS OBLITERANS MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID X30IQ SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 4006-0049 CSP
DISEASE_IDENTIFIER_ID 7396 GARD
DISEASE_IDENTIFIER_ID 7397 GARD
DISEASE_IDENTIFIER_ID 7398 GARD
DISEASE_IDENTIFIER_ID 7399 GARD
DISEASE_IDENTIFIER_ID 7400 GARD
DX 19850101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 85 MSH
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19840412 MSH
MESH_DEFINITION A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE. NDFRT
MESH_DUI D005922 NDFRT
MESH_NAME Glomerulonephritis, IGA NDFRT
MESH_UI M0009301 NDFRT
MMR 20120703 MSH
MN C12.777.419.570.363.608 MSH
MN C13.351.968.419.570.363.608 MSH
MN C20.111.525 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term IgA Nephropathy NCI
NUI N0000001352 NDFRT
PM 85 MSH
PRIMARY_PATH 10021263$10018365$10029149$10038359$IgA nephropathy$Glomerulonephritis and nephrotic syndrome$Nephropathies$Renal and urinary disorders MDR
PRIMARY_SOC 10038359 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/863/berger-disease/resources/1 GARD
RXAUI 3117441 RXNORM
RXAUI 3117442 RXNORM
RXAUI 3165689 RXNORM
RXAUI 3165690 RXNORM
RXAUI 3175371 RXNORM
RXAUI 3175373 RXNORM
RXAUI 3205625 RXNORM
RXAUI 3287610 RXNORM
RXAUI 4223499 RXNORM
RXAUI 5039505 RXNORM
RXCUI 1025732 RXNORM
SMQ_TERM_ADDVERSION 12.1 MDR
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT F MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SMQ_TERM_WEIGHT 1 MDR
SNOMED_CID 197632002 NDFRT
SNOMED_CID 236407003 NDFRT
SNOMED_CID 68779003 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS N02.8 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~N02.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS N02.8 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF IGA NEPHROPATHY ASSOCIATED WITH LIVER DISEASE CHOOSE K76.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 282364005 | IgA nephropathy associated with liver disease | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K76.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~N02.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X30IQ SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T017919 MSH
TERMUI T017920 MSH
TERMUI T017921 MSH
TERMUI T017922 MSH
TERMUI T017923 MSH
TERMUI T017924 MSH
TERMUI T656874 MSH
TERMUI T782095 MSH
TERMUI T811560 MSH
TH NLM (1985) MSH
TH NLM (2007) MSH
TH NLM (2012) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017661

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