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Glioblastoma (CUI C0017636) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017636

NCI Thesaurus Code: C3058  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

RADLEX Definition: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. [MeSH]

GARD Definition: Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy. - this information is from GARD/ORDR/NCATS.

HPO Definition: A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation. [HPO:probinson, pmid:10841526]

NCI-GLOSS Definition: A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.

CSP Definition: malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage and necrosis; may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways.

MSH Definition: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

Synonyms & Abbreviations: (see Synonym Details)
astrocytoma WHO grade IV
Astrocytoma, Grade IV
ASTROCYTOMA, GRADES 3-4
Astrocytomas, Grade IV
Astrozytom (WHO Grad IV)
BRAIN TUMOR, GLIOBLASTOMA MULTIFORME
CANCER, GLIOBLASTOMA MULTIFORME
GBM (Glioblastoma)
GBM - Glioblastoma multiforme
GBM
Glioblastoma [Disease/Finding]
Glioblastoma multiforme (disorder)
glioblastoma multiforme
Glioblastoma, no ICD-O subtype
Glioblastoma, no International Classification of Diseases for Oncology subtype (morphologic abnormality)
Glioblastoma, no International Classification of Diseases for Oncology subtype
Glioblastoma, NOS
Glioblastomas
glioblastoma
GLM - Glioblastoma multiforme
Grade IV Astrocytic Neoplasm
Grade IV Astrocytic Tumor
Grade IV Astrocytomas
Grade IV Astrocytoma
INTRACRANIAL NEOPLASM, GLIOBLASTOMA MULTIFORME
spongioblastoma multiforme
WHO Grade IV Glioma

External Source Codes: 
NCI Thesaurus Code C3058 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coord IM with probably precoord CNS/neopl term + site (IM); for GLIOBLASTOMA WITH SARCOMATOUS COMPONENT see GLIOSARCOMA; for GLIOBLASTOMA, RETINAL see RETINOBLASTOMA MSH
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CODE_REF (C71._) ICDO
Contributing_Source CTEP NCI
CTV3ID .B1M4 SNOMEDCT_US
CTV3ID XM0B6 SNOMEDCT_US
DATE_CREATED 2011-06-09T06:47:23Z HPO
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2013-02-23T09:47:02Z HPO
DATE_LAST_MODIFIED 10/09/2014 RADLEX
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2012-6410 CSP
DISEASE_IDENTIFIER_ID 10039 GARD
DX 19940101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20100131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 94; was GLIOBLASTOMA MULTIFORME 1963-93; GLIOBLASTOMA was see ASTROCYTOMA 1993 MSH
ICD-O-3_Code 9440/3 NCI
ICD-O-3_CODE 9440/3 SNOMEDCT_US
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_CHANGES_TO_CLASS syn RADLEX
LAST_REVIEW_ACTION Modified GARD
MDA 19990101 MSH
MESH_DEFINITION A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. NDFRT
MESH_DUI D005909 NDFRT
MESH_NAME Glioblastoma NDFRT
MESH_UI M0009269 NDFRT
MMR 20120703 MSH
MN C04.557.465.625.600.380.080.335 MSH
MN C04.557.470.670.380.080.335 MSH
MN C04.557.580.625.600.380.080.335 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NUI N0000001347 NDFRT
OL use GLIOBLASTOMA to search GLIOBLASTOMA MULTIFORME 1966-93; search GLIOBLASTOMA under GLIOMA 1980-93 MSH
PM 94; was GLIOBLASTOMA MULTIFORME 1963-93; GLIOBLASTOMA was see ASTROCYTOMA 1993 MSH
PRIMARY_PATH 10018336$10018335$10029211$10029104$Glioblastoma$Glial tumours malignant$Nervous system neoplasms malignant and unspecified NEC$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_PATH 10018337$10018335$10029211$10029104$Glioblastoma multiforme$Glial tumours malignant$Nervous system neoplasms malignant and unspecified NEC$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/2491/glioblastoma/resources/1 GARD
RXAUI 3112078 RXNORM
RXAUI 3165586 RXNORM
RXAUI 3165589 RXNORM
RXCUI 1025895 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 63634009 NDFRT
SNOMEDID M-94403 SNOMEDCT_US
SNOMEDID R-FA357 SNOMEDCT_US
SUBSET_MEMBER 446608001~MAPTARGET~9440/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C71.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C71.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C71.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF GLIOBLASTOMA MULTIFORME OF CENTRAL NERVOUS SYSTEM CHOOSE C72.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF GLIOBLASTOMA MULTIFORME OF SPINAL CORD CHOOSE C72.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 147131000119101 | Glioblastoma multiforme of central nervous system (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 276829003 | Glioblastoma multiforme of spinal cord (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C71.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C72.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C72.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~.B1M4 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0B6 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-94403 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R-FA357 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T017872 MSH
TERMUI T017873 MSH
TERMUI T372663 MSH
TH NLM (1966) MSH
TH NLM (1994) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017636

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