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Gigantism (CUI C0017547) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017547

NCI Thesaurus Code: C93046  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A clinical finding indicating abnormal and excessive body growth and height resulting from the overproduction of human growth hormone.

GARD Definition: Gigantism is abnormally large growth due to an excess of growth hormone (GH) during childhood, before the bone growth plates have closed (epiphyseal fusion). It causes excessive growth in height, muscles, and organs, making the child extremely large for age. Other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness.  It may begin at any age before epiphyseal fusion. The most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much GH, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including Carney complexMcCune-Albright syndrome (MAS); Multiple endocrine neoplasia type 1 (MEN-1); and Neurofibromatosis. Treatment typically includes surgery to remove the tumor and can cure many cases. Medication or radiation therapy may be used to reduce GH release or block the effect of GH. If the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly. - this information is from GARD/ORDR/NCATS.

NCI-GLOSS Definition: A condition in which the whole body or any of its parts grow much larger than normal.

NICHD Definition: Extreme tall stature and other overgrowth manifestations due to increased growth hormone secretion while the skeletal growth plates are open.

CSP Definition: condition of abnormal overgrowth or excessive size of the whole body or any of its parts.

MSH Definition: The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.

Synonyms & Abbreviations: (see Synonym Details)
Disorders with tall stature (disorder)
Disorders with tall stature
Genetic giant
Giantism
Giant
Gigantism (disorder)
Gigantism [Disease/Finding]
GIGANTISM, PITUITARY
gigantism
Normal giant
Pituitary giant
Pituitary Gigantism
Primordial giant

External Source Codes: 
NCI Thesaurus Code C93046 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID C1301 SNOMEDCT_US
CTV3ID XUPjW SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2715-1518 CSP
DISEASE_IDENTIFIER_ID 16985 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D001506 MSH
FX D058495 MSH
HAS_GARD_PAGE true GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age. NDFRT
MESH_DUI D005877 NDFRT
MESH_NAME Gigantism NDFRT
MESH_UI M0009228 NDFRT
MMR 20100625 MSH
MN C05.116.099.492 MSH
MN C05.116.132.479 MSH
MN C19.700.355.528 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Pituitary Gigantism NCI
NUI N0000001332 NDFRT
PRIMARY_PATH 10018265$10002700$10021112$10014698$Gigantism$Anterior pituitary hyperfunction$Hypothalamus and pituitary gland disorders$Endocrine disorders MDR
PRIMARY_SOC 10014698 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6506/gigantism/resources/1 GARD
RXAUI 3165413 RXNORM
RXAUI 3165414 RXNORM
RXAUI 3221168 RXNORM
RXCUI 1024770 RXNORM
SNOMED_CID 363094008 NDFRT
SNOMED_CID 80849007 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E22.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E22.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E22.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS R68.89 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF BECKWITH-WIEDEMANN SYNDROME CHOOSE Q87.3 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 81780002 | Beckwith-Wiedemann syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E22.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~Q87.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R68.89 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~C1301 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUPjW SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T017774 MSH
TERMUI T604658 MSH
TH NLM (1966) MSH
TH NLM (2006) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017547

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