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Gastroesophageal reflux disease (CUI C0017168) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0017168

NCI Thesaurus Code: C26781  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

RADLEX Definition: Retrograde flow of gastric juice (gastric acid) and/or duodenal contents (bile acids; pancreatic juice) into the distal esophagus, commonly due to incompetence of the lower esophageal sphincter. Gastric regurgitation is an extension of this process with retrograde flow into the pharynx or mouth. [MeSH]

PDQ Definition: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter. [HPO:probinson]

MEDLINEPLUS Definition: 

Your esophagus is the tube that carries food from your mouth to your stomach. Gastroesophageal reflux disease (GERD) happens when a muscle at the end of your esophagus does not close properly. This allows stomach contents to leak back, or reflux, into the esophagus and irritate it.

You may feel a burning in the chest or throat called heartburn. Sometimes, you can taste stomach fluid in the back of the mouth. If you have these symptoms more than twice a week, you may have GERD. You can also have GERD without having heartburn. Your symptoms could include a dry cough, asthma symptoms, or trouble swallowing.

Anyone, including infants and children, can have GERD. If not treated, it can lead to more serious health problems. In some cases, you might need medicines or surgery. However, many people can improve their symptoms by

  • Avoiding alcohol and spicy, fatty or acidic foods that trigger heartburn
  • Eating smaller meals
  • Not eating close to bedtime
  • Losing weight if needed
  • Wearing loose-fitting clothes

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

CTCAE Definition: A disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion.

NICHD Definition: Reflux of stomach contents with symptoms and/or complications from the reflux act.

MSH Definition: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Synonyms & Abbreviations: (see Synonym Details)
Acid reflux (finding)
Acid reflux disease
Acid Reflux, Gastric
Acid Reflux
CARDIOESOPHAGEAL RELAXATION, GASTROESOPHAGEAL REFLUX
Esophageal reflux NOS
ESOPHAGEAL REFLUX
Gastric Acid Reflux Disease
Gastric Acid Reflux
Gastro Esophageal Reflux
Gastro oesophageal Reflux
Gastroösophagealer Reflux
Gastro-esophageal reflux disease
Gastro-Esophageal Reflux
Gastro-oesophageal reflux disease
Gastro-oesophageal Reflux
Gastroesophageal Reflux [Disease/Finding]
Gastroesophageal reflux disease (disorder)
Gastroesophageal reflux disease
GASTROESOPHAGEAL REFLUX DIS
gastroesophageal reflux
Gastrooesophageal reflux disease
Gastrooesophageal reflux
GE REFLUX
GERD - Gastro-esophageal reflux disease
GERD
GER
GOR - Gastro-esophageal reflux
GOR - Gastro-oesophageal reflux
GORD - Gastro-esophageal reflux disease
GORD - Gastro-oesophageal reflux disease
Oesophageal reflux
Reflux, Gastric Acid
Reflux, Gastro-Esophageal
Reflux, Gastro-oesophageal
Reflux, Gastroesophageal

External Source Codes: 
NCI Thesaurus Code C26781 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN note ESOPHAGITIS, REFLUX see ESOPHAGITIS, PEPTIC is available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CITE Playbook RADLEX
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X3003 SNOMEDCT_US
CTV3ID XUmHh SNOMEDCT_US
DATE_CREATED 09/23/1999 MEDLINEPLUS
DATE_FIRST_PUBLISHED 2012-07-23 PDQ
DATE_LAST_MODIFIED 2012-07-23 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1248-5846 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20140131 SNOMEDCT_US
EXCLUDES1 newborn esophageal reflux (P78.83) ICD10CM
FX D006356 MSH
FX D018662 MSH
FX D049630 MSH
GENELOCUS ,1,3,q,1,4, OMIM
GENESYMBOL GER OMIM
HN 84; was ESOPHAGEAL REFLUX 1964-83 (Prov 1964-65) MSH
IAN DEFAULT ICD10
MDA 19990101 MSH
MESH_DEFINITION Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER. NDFRT
MESH_DUI D005764 NDFRT
MESH_NAME Gastroesophageal Reflux NDFRT
MESH_UI M0009024 NDFRT
MIMTYPE 5 OMIM
MIMTYPEMEANING Mendelian phenotype or locus, molecular basis unknown. OMIM
MIMTYPEVALUE perc OMIM
MMR 20120703 MSH
MN C06.405.117.119.500.484 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/gerd.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/gerd.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/gerd.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/gerd.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/gerd.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
MSC Reason.Term MTHMST
NCI_THESAURUS_CODE C26781 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Gastroesophageal Reflux Disease NCI
NUI N0000001319 NDFRT
OL use GASTROESOPHAGEAL REFLUX to search ESOPHAGEAL REFLUX 1966-83 MSH
ORDER_NO 13049 ICD10CM
ORIG_STY Disease/diagnosis PDQ
PM 84; was ESOPHAGEAL REFLUX 1966-83 MSH
PRIMARY_PATH 10017885$10017933$10017977$10017947$Gastrooesophageal reflux disease$Gastrointestinal atonic and hypomotility disorders NEC$Gastrointestinal motility and defaecation conditions$Gastrointestinal disorders MDR
PRIMARY_SOC 10017947 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3155476 RXNORM
RXAUI 3162784 RXNORM
RXAUI 3164909 RXNORM
RXAUI 3164910 RXNORM
RXAUI 3164926 RXNORM
RXAUI 3164927 RXNORM
RXAUI 3164928 RXNORM
RXAUI 3231296 RXNORM
RXAUI 4222922 RXNORM
RXAUI 4222923 RXNORM
RXCUI 1022040 RXNORM
SID HP:0004793 HPO
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 235595009 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K21.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K21.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K21.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K21.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P78.83 | DESCENDANTS NOT EXHAUSTIVELY MAPPED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P78.83 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K21.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P78.83 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X3003 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUmHh SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T017372 MSH
TERMUI T017373 MSH
TERMUI T017374 MSH
TERMUI T526387 MSH
TERMUI T528944 MSH
TERMUI T528945 MSH
TERMUI T562605 MSH
TERMUI T779916 MSH
TERMUI T779917 MSH
TH NLM (1964) MSH
TH NLM (2004) MSH
TH NLM (2005) MSH
TH NLM (2012) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0017168

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