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Gamma-Aminobutyric Acid (CUI C0016904) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0016904

NCI Thesaurus Code: C80523  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Amino Acid, Peptide, or Protein

NCIt Definition: A naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission.

MSH Definition: The most common inhibitory neurotransmitter in the central nervous system.

Synonyms & Abbreviations: (see Synonym Details)
.GAMMA.-AMINOBUTYRIC ACID
4 Aminobutanoic Acid
4 Aminobutyric Acid
4-Aminobutanoic Acid
4-Aminobutyric Acid
Aminalone
Aminalon
AMINOBUTYRIC ACID 04
Butanoic acid, 4-amino-
GABA - Gamma-aminobutyric acid
GABA
gamma Aminobutyric Acid
Gamma-aminobutyric acid (substance)
gamma-Aminobutyric Acid [Chemical/Ingredient]
gamma-aminobutyric acid
Piperidic Acid

External Source Codes: 
NCI Thesaurus Code C80523 (see NCI Thesaurus info)
CAS Registry Number 56-12-2 (see NLM ChemIDplus info)
FDA UNII Code 2ACZ6IPC6I

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Gray's 99:1067 FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHEBI_ID CHEBI:16865 NCI
Chemical_Formula C4H9NO2 NCI
Contributing_Source FDA NCI
CTV3ID X807G SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0124-2160 CSP
DX 19790101 MSH
EC agonists:GABA Agonists MSH
EC antagonists & inhibitors:GABA Antagonists MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE 2ACZ6IPC6I NDFRT
FX D018079 MSH
FX D018682 MSH
HN 2001(1975); use AMINOBUTYRIC ACIDS 1966-1974 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION The most common inhibitory neurotransmitter in the central nervous system. NDFRT
MESH_DUI D005680 NDFRT
MESH_NAME gamma-Aminobutyric Acid NDFRT
MESH_UI M0008927 NDFRT
MMR 20120703 MSH
MN D02.241.081.114.500.350 MSH
MN D12.125.190.350 MSH
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007783 NDFRT
NUI N0000191506 NDFRT
PA D018682 MSH
PM 2001; see GABA 1979-2001, see AMINOBUTYRIC ACIDS 1975-1978, see AMINOBUTYRIC ACID 1963-1974 MSH
RN 56-12-2 MSH
RR 31075-51-1 (mono-Li salt) MSH
RR 5959-35-3 (HCl) MSH
RR 6610-05-5 (mono-Na salt) MSH
RR 70582-09-1 (Ca salt (2:1)) MSH
RR 92138-11-9 (Zn salt (2:1)) MSH
RXAUI 140807 RXNORM
RXAUI 3093580 RXNORM
RXAUI 3093583 RXNORM
RXAUI 3108145 RXNORM
RXAUI 3108146 RXNORM
RXAUI 3119440 RXNORM
RXAUI 3162058 RXNORM
RXAUI 3260647 RXNORM
RXAUI 3260651 RXNORM
RXAUI 3612806 RXNORM
RXAUI 4667364 RXNORM
RXAUI 5493204 RXNORM
RXAUI 7236249 RXNORM
RXAUI 7239055 RXNORM
RXAUI 7239056 RXNORM
RXCUI 4617 RXNORM
RXN_ACTIVATED 01/28/2010 RXNORM
RXN_OBSOLETED 08/30/2007 RXNORM
SPL_SET_ID 0012578b-66ff-49a8-8415-693c68ab9c16 MTHSPL
SPL_SET_ID 01416ec2-130a-4c93-8b60-d16d8827084d MTHSPL
SPL_SET_ID 02d67544-c14a-444e-8d4a-c5475816e3c0 MTHSPL
SPL_SET_ID 04e3aa4c-73dc-4e89-8736-d3443d2df9a5 MTHSPL
SPL_SET_ID 0735b8c0-fd9c-4154-9a08-8c2d2200ec93 MTHSPL
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SPL_SET_ID 11c56d03-d663-47b0-ac5a-f4ed3ba7f46b MTHSPL
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SPL_SET_ID 160afc8d-b485-41ac-97ad-96f567ace387 MTHSPL
SPL_SET_ID 1725b5af-fe03-4372-beaf-d6fd9088a1f1 MTHSPL
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SPL_SET_ID 2801988f-18a8-491b-b7fd-132dedc3e4c6 MTHSPL
SPL_SET_ID 29acd686-ca11-42b0-b5cd-5c1a04e45c29 MTHSPL
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SPL_SET_ID 340e8022-614b-4178-8f4a-a2867b50332e MTHSPL
SPL_SET_ID 3501d504-2edd-4f34-9494-a4d684f98611 MTHSPL
SPL_SET_ID 350f76f7-a6de-48b9-a09a-847ba4041180 MTHSPL
SPL_SET_ID 379f8193-c371-4ae9-a272-43c5b9b18349 MTHSPL
SPL_SET_ID 389c57fd-b4cf-4997-a350-043c131cbfc4 MTHSPL
SPL_SET_ID 3a9deae9-f6fd-4a82-934b-d283af571508 MTHSPL
SPL_SET_ID 3ac47bc8-0064-4009-b322-165d3dc864c5 MTHSPL
SPL_SET_ID 3af34476-26df-8ecd-2198-40b6ee5708b0 MTHSPL
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SPL_SET_ID 4b5af55d-98f9-477d-9815-5cb67e44bfbf MTHSPL
SPL_SET_ID 4c9bbe4f-44ae-4f99-8371-a607d81cc8cd MTHSPL
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SPL_SET_ID 5c8f36b2-aec3-442a-bc13-d454a0de252b MTHSPL
SPL_SET_ID 5d86f813-e784-4490-a842-bcb78eb0d9a4 MTHSPL
SPL_SET_ID 5dbfb94c-0bbf-4096-baf5-c6690a2d0997 MTHSPL
SPL_SET_ID 66bc2054-8b63-40bd-9ba8-4b9ff333046d MTHSPL
SPL_SET_ID 6e77a40c-6c9d-44ed-8a62-1b3a508a69dc MTHSPL
SPL_SET_ID 6f49de96-1090-46bc-b7bf-0dc70f7d9530 MTHSPL
SPL_SET_ID 6f9b446b-f116-47fc-981f-daee3b0868c6 MTHSPL
SPL_SET_ID 701b69d8-cce8-42de-a770-96020c1a870a MTHSPL
SPL_SET_ID 70251489-1511-485e-bb95-6eaac218c27b MTHSPL
SPL_SET_ID 7464141c-7f51-4c45-8f17-8ba403e09a50 MTHSPL
SPL_SET_ID 74bdd5ad-0f93-4f2e-87a1-960d68458314 MTHSPL
SPL_SET_ID 77d868f4-d7ab-422a-8fbd-d33ca36f3e42 MTHSPL
SPL_SET_ID 787ebb96-e635-4d45-a2b0-414bf848d862 MTHSPL
SPL_SET_ID 788296f9-06bd-4821-bd7e-8fdad94dc4bd MTHSPL
SPL_SET_ID 7c76bce0-5f91-4c32-a1d9-b2cd607418c2 MTHSPL
SPL_SET_ID 8138add4-5a74-4545-8482-f981f09ae135 MTHSPL
SPL_SET_ID 8965ee35-89b9-4c11-9cee-fdcbe886cf6e MTHSPL
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SPL_SET_ID 8daa83bd-5c56-4a9e-8570-b4db2811dc06 MTHSPL
SPL_SET_ID 91356085-a6d8-4a41-8197-785fc21fb9de MTHSPL
SPL_SET_ID 91916d24-940c-4f6c-85ef-f1524f1db5c7 MTHSPL
SPL_SET_ID 971d503f-217b-4c35-88d0-790c1eb89447 MTHSPL
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SPL_SET_ID b3abed0f-4d8c-42b5-8b28-f7bfb3fcb0eb MTHSPL
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SPL_SET_ID b6637f00-3660-4fc5-acbd-4f1dfb02e80d MTHSPL
SPL_SET_ID b720c99f-feaa-4453-ba4a-c3377501f7b8 MTHSPL
SPL_SET_ID bbbd8cca-f746-4d68-bcef-f44b4ac44b97 MTHSPL
SPL_SET_ID bd9698e8-1f5e-4881-8b58-beb6b632198e MTHSPL
SPL_SET_ID c3f47985-0027-4fa7-aab2-5bc6ca79a6e8 MTHSPL
SPL_SET_ID c54d391e-33d1-4af8-a510-321a544c50c4 MTHSPL
SPL_SET_ID d1bbc5b7-984b-46c9-89f7-e97942f79b3e MTHSPL
SPL_SET_ID d7b23a45-a1e6-4c85-a9fd-4bc6f9542ae7 MTHSPL
SPL_SET_ID dd6b7ad0-0dca-40a0-9b38-5856f1893281 MTHSPL
SPL_SET_ID e03becf9-dd73-48fc-9faa-90d8243c725b MTHSPL
SPL_SET_ID e86bc48a-ae6b-4909-b94a-6b1df50ebfc4 MTHSPL
SPL_SET_ID e96ed884-239a-4676-aa3c-a472d8e23a61 MTHSPL
SPL_SET_ID eb358ea3-3eb8-487b-9a1a-144f97c56559 MTHSPL
SPL_SET_ID eec917da-5527-493b-8928-1128b5597ba5 MTHSPL
SPL_SET_ID f075a58f-2977-44b4-838d-a24ae0bc550c MTHSPL
SPL_SET_ID f112645c-c312-4a7a-9c08-4f69bf785185 MTHSPL
SPL_SET_ID f13a92ec-bb94-4ebd-acaa-b9ad14d67cac MTHSPL
SPL_SET_ID f2c2a226-54a3-42bd-ae2a-20ada30179aa MTHSPL
SPL_SET_ID f501c511-2aa2-4c12-94ad-1cc42b18ef3e MTHSPL
SPL_SET_ID f51b4ba4-5a27-447d-8860-1ed1dc1d7138 MTHSPL
SPL_SET_ID f9865bc1-2699-4cee-8a23-88ae4d7f8629 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X807G SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T017183 MSH
TERMUI T017184 MSH
TERMUI T017185 MSH
TERMUI T017187 MSH
TERMUI T017188 MSH
TERMUI T017189 MSH
TH NLM (1975) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4987^Active/Master NDFRT
VANDF_RECORD 50.6^5009^Active/Master NDFRT
VUID 4034308 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0016904

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