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Folic Acid (CUI C0016410) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0016410

NCI Thesaurus Code: C510  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Vitamin

Semantic Type: Organic Chemical

NCIt Definition: A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)

PDQ Definition: A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to and purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. Check for active clinical trials using this agent. (NCI Thesaurus)

MEDLINEPLUS Definition: 

Folic acid is a B vitamin. It helps the body make healthy new cells. Everyone needs folic acid. For women who may get pregnant, it is really important. Getting enough folic acid before and during pregnancy can prevent major birth defects of her baby's brain or spine.

Foods with folic acid in them include

  • Leafy green vegetables
  • Fruits
  • Dried beans, peas, and nuts
  • Enriched breads, cereals and other grain products

If you don't get enough folic acid from the foods you eat, you can also take it as a dietary supplement.

NIH: National Institutes of Health Office of Dietary Supplements

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Folate helps to make red blood cells. It is found in whole-grain breads and cereals, liver, green vegetables, orange juice, lentils, beans, and yeast. Folate is water-soluble (can dissolve in water) and must be taken in every day. Not enough folate can cause anemia (a condition in which the number of red blood cells is below normal), diseases of the heart and blood vessels, and defects in the brain and spinal cord in a fetus. Folate is being studied with vitamin B12 in the prevention and treatment of cancer.

CRCH Definition: Synthetic folate in fortified foods and supplements containing a single glutamate molecule.

CSP Definition: folate and its derivatives.

MSH Definition: A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

NPO Definition: A pterin compound which contains para-aminobenzoic acid and L-glutamate unit conjugated with the pterin structure.

Synonyms & Abbreviations: (see Synonym Details)
2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
B9, Vitamin
FA - Folic acid
FA
folacin
Folic acid (substance)
Folic Acid [Chemical/Ingredient]
Folic acid preparation
folic acid
folicin
L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
Lactobacillus casei factor
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid
N-Pteroyl-L-glutamic acid
PGA
Product containing folic acid (medicinal product)
Product containing folic acid
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamic acid
Pteroylglutamic acid
Pteroylmonoglutamic Acid
Vitamin B c
Vitamin B9
Vitamin B<sub>c</sub>
Vitamin B>c<
vitamin Bc
vitamin M

External Source Codes: 
NCI Thesaurus Code C510 (see NCI Thesaurus info)
CAS Registry Number 59-30-3 (see NLM ChemIDplus info)
FDA UNII Code 935E97BOY8
NSC Code 3073 (see NCI DTP info)
PDQ Closed Trial Search ID 39641
PDQ Open Trial Search ID 39641 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AN BI BL CF CH CL CS CT EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:27470 NCI
Chemical_Formula C19H19N7O6 NCI
CODE NPO_422 NPO
Contributing_Source CRCH NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID i33.. SNOMEDCT_US
CTV3ID XM0lJ SNOMEDCT_US
DATE_CREATED 03/27/2002 MEDLINEPLUS
DATE_LAST_MODIFIED 2008-10-06 PDQ
DB_XR_ID CHEBI:27470 NPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-0732 CSP
DID 3147-0915 CSP
DX 19600101 MSH
EC antagonists & inhibitors:Folic Acid Antagonists MSH
EC deficiency:Folic Acid Deficiency MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE 935E97BOY8 DRUGBANK
FDA_UNII_CODE 935E97BOY8 NDFRT
HN HOMOFOLIC ACID was heading 1975-84 MSH
INFOODS FOLAC NCI
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19990101 MSH
MESH_DEFINITION A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. NDFRT
MESH_DUI D005492 NDFRT
MESH_NAME Folic Acid NDFRT
MESH_UI M0008658 NDFRT
MMR 20160531 MSH
MN D03.633.100.733.631.400 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/folicacid.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/folicacid.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/folicacid.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/folicacid.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL NIH Office of Dietary Supplements https://ods.od.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C510 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007151 NDFRT
NUI N0000145892 NDFRT
OL use FOLIC ACID/AA to search HOMOFOLIC ACID 1975-84 MSH
ORIG_STY Drug/agent PDQ
PA D006397 MSH
PA D014803 MSH
PID 2296 PDQ
PM HOMOFOLIC ACID was heading 1975-84 MSH
RDF_ID CHEBI_27470 NPO
RN 0 MSH
RN 935E97BOY8 MSH
RR 21179-34-0 MSH
RR 36653-55-1 MSH
RR 59-30-3 (Folic Acid) MSH
RR 60672-17-5 MSH
RR 6484-89-5 (Folic Acid, Monosodium Salt) MSH
RR 65165-91-5 MSH
RR 65165-92-6 MSH
RR 78168-16-8 MSH
RR 9P9W8GGU78 MSH
RXAUI 1136283 RXNORM
RXAUI 138101 RXNORM
RXAUI 2071035 RXNORM
RXAUI 2597072 RXNORM
RXAUI 2622417 RXNORM
RXAUI 2989161 RXNORM
RXAUI 3158741 RXNORM
RXAUI 3158742 RXNORM
RXAUI 3161196 RXNORM
RXAUI 3161205 RXNORM
RXAUI 3185229 RXNORM
RXAUI 3225963 RXNORM
RXAUI 3255798 RXNORM
RXAUI 4224039 RXNORM
RXAUI 5461959 RXNORM
RXCUI 202634 RXNORM
RXCUI 4511 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID NUTR00025 DRUGBANK
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SPL_SET_ID fa1db7ce-a733-4036-aa4b-c4aec29829c1 MTHSPL
SPL_SET_ID fa8470fb-6e36-4c5a-8b44-cc9965638bb5 MTHSPL
SPL_SET_ID fb8d7ace-df0c-49f6-8d91-fa2d76e596d5 MTHSPL
SPL_SET_ID fb8eb411-0bf2-4ba8-ae9a-b08f113d54d7 MTHSPL
SPL_SET_ID fc729ca5-3846-48fd-8d8c-d2b6a7563741 MTHSPL
SPL_SET_ID fe0a737e-4f28-40d8-b4a7-090edf86a823 MTHSPL
SPL_SET_ID ff14da00-293e-4aed-abbf-98dd15eb84c3 MTHSPL
SPL_SET_ID ff80ef4d-e04c-9f83-2b56-cccc30028f72 MTHSPL
SPL_SET_ID ffb770b4-8b6d-445c-9faa-8a61efd7d6b0 MTHSPL
SPL_SET_ID ffc79b35-c32a-4a36-a8b4-20e2a816c9de MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~i33.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0lJ SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T016712 MSH
TERMUI T016713 MSH
TERMUI T016714 MSH
TERMUI T016716 MSH
TERMUI T784558 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (2012) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
Tolerable_Level Y NCI
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit mcg NCI
US_Recommended_Intake Y* (*for women of childbearing age) NCI
USDA_ID 431 NCI
VANDF_RECORD 50.416^99^Active/Master NDFRT
VANDF_RECORD 50.6^58^Active/Master NDFRT
VUID 4017507 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0016410

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