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Fluorouracil (CUI C0016360) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0016360

NCI Thesaurus Code: C505  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Nucleic Acid, Nucleoside, or Nucleotide

NCIt Definition: An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.

PDQ Definition: An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.

CSP Definition: pyrimidine analog that is an antineoplastic antimetabolite.

MSH Definition: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

NPO Definition: An organofluorine compound, which has uracil as the funcitonal parent.

Synonyms & Abbreviations: (see Synonym Details)
19893
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
2,4-Dioxo-5-fluoropyrimidine
5 Fluorouracil
5-Fluoracil
5-Fluoro-2,4(1H, 3H)-pyrimidinedione
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoropyrimidine-2,4-dione
5-fluorouracil injection
5-Fluorouracil
5-Fluracil
5-FU injection
5-FU topical
5-FU
51-21-8
5fluorouracil
5Fluracil
5FU injection
5FU
AccuSite
Adrucil
Allergan Brand of Fluorouracil
Carac
CSP Brand of Fluorouracil
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
Efudex
Fluoro Uracile ICN
Fluoro Uracil
Fluoro-Uracile ICN
Fluoroplex
Fluorouracil (substance)
Fluorouracil [Chemical/Ingredient]
fluorouracil injection
Fluorouracil Teva Brand
Fluorouracilo
Fluorouracilum
fluorouracil
Fluorouracil®
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluril
Fluroblastin
Flurodex
FU
ICN Brand of Fluorouracil
Product containing fluorouracil (medicinal product)
Product containing fluorouracil
Ribofluor
ribosepharm Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
Teva Brand of Fluorouracil

External Source Codes: 
NCI Thesaurus Code C505 (see NCI Thesaurus info)
CAS Registry Number 51-21-8 (see NLM ChemIDplus info)
FDA UNII Code U3P01618RT
NSC Code 19893 (see NCI DTP info)
PDQ Closed Trial Search ID 43130
PDQ Open Trial Search ID 43130 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Palliative treatment: Colorectal cancer, Breast cancer, Stomach cancer, Pancreatic cancer. Topical treatment for the following: Superficial basal cell carcinoma that cannot be treated with surgery, and Actinic keratosis. NCI
ACTIVE 1 SNOMEDCT_US
ANSWER_CODE 7 LNC
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:46345 NCI
Chemical_Formula C4H3FN2O2 NCI
CODE NPO_365 NPO
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID h32.. SNOMEDCT_US
CTV3ID XUWs4 SNOMEDCT_US
DATE_LAST_MODIFIED 2016-01-11 PDQ
DB_XR_ID CHEBI:46345 NPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1375-4843 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FDA_UNII_CODE U3P01618RT DRUGBANK
FDA_UNII_CODE U3P01618RT NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. NDFRT
MESH_DUI D005472 NDFRT
MESH_NAME Fluorouracil NDFRT
MESH_UI M0008631 NDFRT
MMR 20160531 MSH
MN D03.383.742.698.875.404 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C505 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007099 NDFRT
NUI N0000146166 NDFRT
ORIG_STY Drug/agent PDQ
PA D000963 MSH
PA D000964 MSH
PA D007166 MSH
PID 757 PDQ
RDF_ID CHEBI_46345 NPO
RN 0 MSH
RN U3P01618RT MSH
RR 10318-20-4 (mono-Na salt) MSH
RR 51-21-8 (Fluorouracil) MSH
RR 57050-04-1 (K salt) MSH
RR 57172-36-8 (mononitrate) MSH
RR 68021-61-4 (mono-K salt) MSH
RXAUI 1136276 RXNORM
RXAUI 1136280 RXNORM
RXAUI 1190128 RXNORM
RXAUI 1359795 RXNORM
RXAUI 137496 RXNORM
RXAUI 2071012 RXNORM
RXAUI 2599233 RXNORM
RXAUI 2854879 RXNORM
RXAUI 2866629 RXNORM
RXAUI 3092241 RXNORM
RXAUI 3094120 RXNORM
RXAUI 3094127 RXNORM
RXAUI 3094302 RXNORM
RXAUI 3158164 RXNORM
RXAUI 3158165 RXNORM
RXAUI 3161061 RXNORM
RXAUI 3161062 RXNORM
RXAUI 3161064 RXNORM
RXCUI 202632 RXNORM
RXCUI 202633 RXNORM
RXCUI 224945 RXNORM
RXCUI 285133 RXNORM
RXCUI 4492 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00516 DRUGBANK
SID EXPT03204 DRUGBANK
SOS anticancer drug that inhibits protein activity related to DNA synthesis NPO
SPL_SET_ID 1911e06a-2f16-4b99-adfa-4b914d559e1e MTHSPL
SPL_SET_ID 1b2f6145-b338-42ed-88a7-f4da65c59164 MTHSPL
SPL_SET_ID 1b835751-d6a4-49b6-b0f8-23ab31b0d04e MTHSPL
SPL_SET_ID 21af1777-87f7-4e40-9917-f1677e7ff1a5 MTHSPL
SPL_SET_ID 258bb79a-56b3-4f46-ade6-7331ec031074 MTHSPL
SPL_SET_ID 35de1c1c-bef5-46c5-b6f8-ea032147411c MTHSPL
SPL_SET_ID 4d8f6f8f-a69a-48db-8ee1-3b23989cb11f MTHSPL
SPL_SET_ID 513ca7e7-6867-4f15-b688-6469bb8c82de MTHSPL
SPL_SET_ID 58fa81e2-9dbc-4cef-82d4-e5dc4aec5b26 MTHSPL
SPL_SET_ID 59de2709-00b8-4f0a-867c-f0dfeb947192 MTHSPL
SPL_SET_ID 64b6cb19-b6c0-4e02-9fae-39d5d61e15e4 MTHSPL
SPL_SET_ID 66d451fe-2436-494c-80c5-4528c8e34369 MTHSPL
SPL_SET_ID 6795f2b1-1381-4a4f-ad34-2c28ebd1cfaf MTHSPL
SPL_SET_ID 744737c5-0d96-4214-82ab-6cff016b1ea0 MTHSPL
SPL_SET_ID 85ab7938-377f-497d-aab0-6a1223396372 MTHSPL
SPL_SET_ID 8eff167f-203a-4a81-b2fc-d8773bc3555e MTHSPL
SPL_SET_ID 9a2c044d-83e4-42b4-9797-c344b8d3d152 MTHSPL
SPL_SET_ID a85ab26a-05ea-498f-8f34-564a925fa9d9 MTHSPL
SPL_SET_ID a8857fe2-0bd1-4111-9eba-1eac25516e2e MTHSPL
SPL_SET_ID acca0036-f19c-459b-9dfc-9592f1cd588d MTHSPL
SPL_SET_ID b4328ae3-f48f-40b1-9719-1c1aced7c734 MTHSPL
SPL_SET_ID b90e0da7-f702-4f09-9488-74f2bb20e9ac MTHSPL
SPL_SET_ID beb8c6c5-4b6e-4770-b6d4-718e33c7a2ff MTHSPL
SPL_SET_ID bf851a7f-902d-4f1d-9d19-fd9cd5701fcd MTHSPL
SPL_SET_ID c45f5286-a52b-43e5-8a6f-d0312e7da0c8 MTHSPL
SPL_SET_ID d91670fd-7825-4fb9-afc7-a03a595fc70c MTHSPL
SPL_SET_ID e0794add-67a7-4308-93e9-f889472716cc MTHSPL
SPL_SET_ID e301c810-0edc-4d21-8ccd-ec9653249019 MTHSPL
SPL_SET_ID e4acd6ec-d981-4756-9c59-7ee981be9c12 MTHSPL
SPL_SET_ID fdf2a165-2ca4-48be-89c1-570e6010b47c MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~h32.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWs4 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T016643 MSH
TERMUI T016644 MSH
TERMUI T016645 MSH
TERMUI T016647 MSH
TERMUI T476160 MSH
TERMUI T476161 MSH
TERMUI T626254 MSH
TERMUI T626255 MSH
TERMUI T626256 MSH
TERMUI T626257 MSH
TERMUI T626258 MSH
TERMUI T626259 MSH
TERMUI T626260 MSH
TERMUI T626261 MSH
TERMUI T626262 MSH
TERMUI T626283 MSH
TERMUI T626284 MSH
TERMUI T771105 MSH
TH BAN (19XX) MSH
TH CA MSH
TH DE MSH
TH FDA SRS (2014) MSH
TH FR MSH
TH INN (19XX) MSH
TH NLM (2003) MSH
TH NLM (2006) MSH
TH NLM (2011) MSH
TH UNK (19XX) MSH
TH USAN (1962) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^401^Active/Master NDFRT
VANDF_RECORD 50.6^173^Active/Master NDFRT
VUID 4017806 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0016360

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