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Chronic Fatigue Syndrome (CUI C0015674) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0015674

NCI Thesaurus Code: C3037  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis.

GARD Definition: Chronic fatigue syndrome is a condition that causes extreme, long-lasting fatigue which can limit the ability to participate in ordinary, daily activities. It generally occurs in young adults between the ages of 20 and 40. The main symptom of this condition is disabling fatigue that does not improve with rest. Other signs and symptoms may include muscle pain; joint pain; concentration and memory problems; headaches; sleep problems; fever; sore throat; and/or tender lymph nodes. The exact cause of chronic fatigue syndrome is not known, but it has been proposed that infectious agents, immune system impairment and/or hormonal system deregulation may be involved. There is no cure for this condition; the goal of treatment is to improve symptoms. Medications may be used to treat pain, sleep disorders and other associated problems. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Chronic fatigue syndrome (CFS) is a disorder that causes extreme fatigue. This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities.

The main symptom of CFS is severe fatigue that lasts for 6 months or more. You also have at least four of these other symptoms:

  • Feeling unwell for more than 24 hours after physical activity
  • Muscle pain
  • Memory problems
  • Headaches
  • Pain in multiple joints
  • Sleep problems
  • Sore throat
  • Tender lymph nodes

CFS is hard to diagnose. There are no tests for it, and other illnesses can cause similar symptoms. Your doctor has to rule out other diseases before making a diagnosis of CFS.

No one knows what causes CFS. It is most common in women in their 40s and 50s, but anyone can have it. It can last for years. There is no cure for CFS, so the goal of treatment is to improve symptoms. Medicine may treat pain, sleep disorders, and other problems. Lifestyle changes, coping techniques, and a special, gradual exercise program can also help.

Centers for Disease Control and Prevention

NCI-GLOSS Definition: A condition lasting for more than 6 months in which a person feels tired most of the time and may have trouble concentrating and carrying out daily activities. Other symptoms include sore throat, fever, muscle weakness, headache, and joint pain.

CSP Definition: distinctive syndrome characterized by chronic fatigue, mild fever, lymphadenopathy, headache, myalgia, arthralgia, depression, and memory loss; candidate etiologic agents include Epstein-Barr and other herpesviruses.

MSH Definition: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)

Synonyms & Abbreviations: (see Synonym Details)
Benign myalgic encephalomyelitis
CFIDS
CFS - Chronic fatigue syndrome
CFS
chronic fatigue and immune dysfunction syndrome
Chronic Fatigue Disorders
Chronic Fatigue Disorder
CHRONIC FATIGUE DIS
Chronic Fatigue Fibromyalgia Syndrome
Chronic fatigue syndrome (disorder)
Chronic fatigue syndrome NOS
Chronic Fatigue Syndromes
chronic fatigue syndrome
Chronic fatigue, unspecified
Chronic Fatigue-Fibromyalgia Syndromes
Chronic Fatigue-Fibromyalgia Syndrome
Disorders, Chronic Fatigue
ENCEPH MYALGIC
ENCEPHALOMYELITIS, EPIDEMIC MYALGIC
Encephalomyelitis, Myalgic
Fatigue Disorder, Chronic
Fatigue Disorders, Chronic
Fatigue Syndrome, Chronic [Disease/Finding]
Fatigue Syndrome, Chronic
Fatigue Syndrome, Postviral
Fatigue Syndromes, Chronic
Fatigue Syndromes, Postviral
Fatigue-Fibromyalgia Syndrome, Chronic
Fatigue-Fibromyalgia Syndromes, Chronic
ICELAND DISEASE
INFECT MONONUCLEOSIS LIKE SYNDROME CHRONIC
Infectious Mononucleosis Like Syndrome, Chronic
Infectious Mononucleosis-Like Syndrome, Chronic
ME - Myalgic encephalomyelitis
ME/CFS
ME
Myalgic encephalomyelitis syndrome
Myalgic encephalomyelitis
MYALGIC ENCEPH
NEUROMYASTHENIA, EPIDEMIC
Post viral fatigue syndrome
Post-viral fatigue syndrome NOS
Post-viral fatigue syndrome
Postviral fatigue syndrome (disorder)
Postviral Fatigue Syndromes
Postviral fatigue syndrome
Royal Free disease
ROYAL FREE DIS
SEID
Syndrome, Chronic Fatigue-Fibromyalgia
Syndromes, Chronic Fatigue-Fibromyalgia
Syndromes, Postviral Fatigue
Systemic Exertion Intolerance Disease
YUPPIE FLU

External Source Codes: 
NCI Thesaurus Code C3037 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a clinical entity: do not confuse with "chronic fatigue" ( = FATIGUE (IM) + CHRONIC DISEASE (NIM)); DF: CFIDS MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CTV3ID Xa01F SNOMEDCT_US
CTV3ID XUFfS SNOMEDCT_US
DATE_CREATED 02/19/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0944-7840 CSP
DISEASE_IDENTIFIER_ID 4892 GARD
DX 19900101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 chronic fatigue syndrome NOS (R53.82) ICD10CM
EXCLUDES1 postviral fatigue syndrome (G93.3) ICD10CM
FX D005356 MSH
HAS_GARD_PAGE true GARD
HN 90 MSH
HN Introduced 2000. AOD
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Benign myalgic encephalomyelitis ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19890525 MSH
MESH_DEFINITION A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9) NDFRT
MESH_DUI D015673 NDFRT
MESH_NAME Fatigue Syndrome, Chronic NDFRT
MESH_UI M0024027 NDFRT
MMR 20010725 MSH
MN C02.330 MSH
MN C05.651.310 MSH
MN C10.228.440.600 MSH
MN C10.668.364 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/chronicfatiguesyndrome.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/chronicfatiguesyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL NIH Office of Research on Women's Health http://www4.od.nih.gov/orwh/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000003304 NDFRT
ORDER_NO 06505 ICD10CM
ORDER_NO 28780 ICD10CM
PM 90 MSH
PRIMARY_PATH 10008874$10003550$10018073$10018065$Chronic fatigue syndrome$Asthenic conditions$General system disorders NEC$General disorders and administration site conditions MDR
PRIMARY_PATH 10057244$10047465$10047438$10021881$Post viral fatigue syndrome$Viral infections NEC$Viral infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10018065 MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7121/chronic-fatigue-syndrome/resources/1 GARD
RXAUI 3133384 RXNORM
RXAUI 3133387 RXNORM
RXAUI 3133389 RXNORM
RXAUI 3133390 RXNORM
RXAUI 3153800 RXNORM
RXAUI 3159933 RXNORM
RXAUI 3159934 RXNORM
RXAUI 3159935 RXNORM
RXAUI 3180986 RXNORM
RXAUI 3200481 RXNORM
RXAUI 3222930 RXNORM
RXAUI 3232681 RXNORM
RXCUI 1024042 RXNORM
SNOMED_CID 51771007 NDFRT
SNOMED_CID 52702003 NDFRT
SOS Etiology is suspected to be viral or immunologic AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G93.3 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G93.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G93.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS R53.82 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G93.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R53.82 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa01F SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUFfS SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T046396 MSH
TERMUI T046397 MSH
TERMUI T046398 MSH
TERMUI T046399 MSH
TERMUI T046400 MSH
TERMUI T046401 MSH
TERMUI T046402 MSH
TERMUI T046403 MSH
TERMUI T046404 MSH
TERMUI T368095 MSH
TERMUI T368096 MSH
TH NLM (1990) MSH
TH NLM (1995) MSH
TH NLM (1997) MSH
TH NLM (2000) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0015674

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