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Ergotamine (CUI C0014710) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0014710

NCI Thesaurus Code: C61751  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

MSH Definition: A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.

Synonyms & Abbreviations: (see Synonym Details)
(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione
12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione
Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-
Ergotamina
Ergotamine (substance)
Ergotamine [Chemical/Ingredient]
Ergotamine
Ergotaminum
Ergotamin
Product containing ergotamine (medicinal product)
Product containing ergotamine

External Source Codes: 
NCI Thesaurus Code C61751 (see NCI Thesaurus info)
CAS Registry Number 113-15-5 (see NLM ChemIDplus info)
FDA UNII Code PR834Q503T

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:64318 NCI
Chemical_Formula C33H35N5O5 NCI
Contributing_Source FDA NCI
CTV3ID x01R8 SNOMEDCT_US
CTV3ID XUXt8 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19630101 MSH
EC analogs & derivatives:Ergotamines MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE PR834Q503T DRUGBANK
FDA_UNII_CODE PR834Q503T NDFRT
HN ERGOTAMINE TARTRATE was ERGOTAMINE TARTRATE (NM) 1975-91 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS. NDFRT
MESH_DUI D004878 NDFRT
MESH_NAME Ergotamine NDFRT
MESH_UI M0007662 NDFRT
MMR 20160531 MSH
MN D03.132.327.412.400 MSH
MN D03.633.400.562.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006354 NDFRT
NUI N0000020412 NDFRT
OL use ERGOTAMINE (NM) to search ERGOTAMINE TARTRATE (NM) 1980-91 MSH
PA D010120 MSH
PA D014662 MSH
PA D017366 MSH
PA D018712 MSH
PA D058646 MSH
PM ERGOTAMINE TARTRATE was indexed under ERGOTAMINE DERIVATIVES 1977-91 & under ERGOTAMINE 1975-76 MSH
RN PR834Q503T MSH
RR 113-15-5 (Ergotamine) MSH
RR 639-81-6 MSH
RR 7620-10-2 (Ergotamine Tartrate) MSH
RR MRU5XH3B48 MSH
RXAUI 122063 RXNORM
RXAUI 2628067 RXNORM
RXAUI 3151259 RXNORM
RXAUI 3151260 RXNORM
RXAUI 3155230 RXNORM
RXAUI 3155236 RXNORM
RXAUI 3155241 RXNORM
RXAUI 6395342 RXNORM
RXAUI 6395366 RXNORM
RXCUI 4025 RXNORM
SID APRD00677 DRUGBANK
SPL_SET_ID 19479eeb-f507-48a8-bca3-c9cc0a0f6021 MTHSPL
SPL_SET_ID 1bfd4827-5123-4dbb-8f94-7b097f5bfd5c MTHSPL
SPL_SET_ID 1c066197-dea6-4705-9b4a-8703dd564a2a MTHSPL
SPL_SET_ID 3a31ad0c-7bdd-544b-f5df-a99d04cf541c MTHSPL
SPL_SET_ID 6a105e44-b558-45c1-9c91-fe1f3dfc5bd5 MTHSPL
SPL_SET_ID 990f47f3-a08a-496a-b0c0-ae7193a11b01 MTHSPL
SPL_SET_ID b4a06de6-f837-43a8-ae7a-aadb38dd2a7d MTHSPL
SPL_SET_ID ed1ede57-1317-491a-9ebb-edee9aef5b3b MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01R8 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUXt8 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T014923 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.6^833^Active/Master NDFRT
VUID 4022407 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0014710

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