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Epinephrine (CUI C0014563) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0014563

NCI Thesaurus Code: C473  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Hormone

Semantic Type: Pharmacologic Substance

NCIt Definition: The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation.

PDQ Definition: The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation. Check for active clinical trials using this agent. (NCI Thesaurus)

CSP Definition: active sympathomimetic hormone from the adrenal medulla in most species; it stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels; used in treatment of asthma and cardiac failure and to delay absorption of local anesthetics.

MSH Definition: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Synonyms & Abbreviations: (see Synonym Details)
(-)-(R)-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
adrenaline
adrenalin
Adrenal
Epinefrina
Epinefrin
Epinephrine (substance)
Epinephrine [Chemical/Ingredient]
epinephrine
Epinephrinum
Epinephrin
Epi
Product containing adrenaline
Product containing epinephrine (medicinal product)
Product containing epinephrine
Therapeutic Epinephrine

External Source Codes: 
NCI Thesaurus Code C473 (see NCI Thesaurus info)
CAS Registry Number 51-43-4 (see NLM ChemIDplus info)
FDA UNII Code YKH834O4BH
NSC Code 62786 (see NCI DTP info)
PDQ Closed Trial Search ID 41857
PDQ Open Trial Search ID 41857 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Gray's 99:936, 937 tbl.8.1; Bloom & Fawcett 94:506; Burt 93:100 FMA
AUTHORITY Gray's 99:936, 937 tbl.8.1 FMA
AUTHORITY Oxford English Dictionary 93V1:837 FMA
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:28918 NCI
Chemical_Formula C9H13NO3 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID k82.. SNOMEDCT_US
CTV3ID XUWv8 SNOMEDCT_US
DATE_LAST_MODIFIED 2008-10-16 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-5502 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE YKH834O4BH DRUGBANK
FDA_UNII_CODE YKH834O4BH NDFRT
FX D011941 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. NDFRT
MESH_DUI D004837 NDFRT
MESH_NAME Epinephrine NDFRT
MESH_UI M0007583 NDFRT
MMR 20160705 MSH
MN D02.033.100.291.310 MSH
MN D02.092.063.291.310 MSH
MN D02.092.211.215.311.461 MSH
MN D02.092.311.461 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C473 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006261 NDFRT
NUI N0000146377 NDFRT
ORIG_STY Drug/agent PDQ
PA D000316 MSH
PA D000318 MSH
PA D001993 MSH
PA D009184 MSH
PA D013566 MSH
PA D014662 MSH
PID 5069 PDQ
RN YKH834O4BH MSH
RR 30Q7KI53AK MSH
RR 51-43-4 (Epinephrine) MSH
RR M1NJX34RVJ MSH
RR WBB047OO38 MSH
RXAUI 121034 RXNORM
RXAUI 2070752 RXNORM
RXAUI 2596988 RXNORM
RXAUI 3086377 RXNORM
RXAUI 3091067 RXNORM
RXAUI 3093530 RXNORM
RXAUI 3106847 RXNORM
RXAUI 3150866 RXNORM
RXAUI 3150867 RXNORM
RXAUI 3154966 RXNORM
RXAUI 3154976 RXNORM
RXAUI 3726083 RXNORM
RXAUI 3805835 RXNORM
RXCUI 3992 RXNORM
SID APRD00450 DRUGBANK
SID EXPT00496 DRUGBANK
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SUBSET_MEMBER 900000000000497000~MAPTARGET~k82.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWv8 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T014746 MSH
TERMUI T014747 MSH
TERMUI T014748 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH NLM (2014) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA
VANDF_RECORD 50.416^631^Active/Master NDFRT
VANDF_RECORD 50.6^361^Active/Master NDFRT
VUID 4018034 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0014563

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