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Ephedrine (CUI C0014479) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0014479

NCI Thesaurus Code: C472  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: An alkaloid that is an hydroxylated form of phenethylamineand sympathomimetic amine, with potential bronchodilatory and anti-hypotensive activities. Following administration, ephedrine activates post-synaptic noradrenergic receptors. Activation of alpha-adrenergic receptors in the vasculature induces vasoconstriction, and activation of beta-adrenergic receptors in the lungs leads to bronchodilation.

CSP Definition: alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine; has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression.

MSH Definition: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

Synonyms & Abbreviations: (see Synonym Details)
(-)-Ephedrine
(1R,2S)-1-Phenyl-1-hydroxy-2-methylaminopropane
(1R,2S)-2-methylamino-1-phenyl-propan-1-ol
[R-(R*,S*)]-alpha-[1-(Methylamino)ethyl]benzenemethanol
Ephedrine (substance)
Ephedrine [Chemical/Ingredient]
Ephedrine Erythro Isomer
ephedrine
Erythro Isomer of Ephedrine
L(-)-Ephedrine
L-Ephedrine
L-erythro-2-(Methylamino)-1-phenylpropan-1-ol
Product containing ephedrine (medicinal product)
Product containing ephedrine

External Source Codes: 
NCI Thesaurus Code C472 (see NCI Thesaurus info)
CAS Registry Number 299-42-3 (see NLM ChemIDplus info)
FDA UNII Code GN83C131XS
NSC Code 8971 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15407 NCI
Chemical_Formula C10H15NO NCI
Contributing_Source FDA NCI
CTV3ID x01D6 SNOMEDCT_US
CTV3ID XUWv4 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-6732 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE GN83C131XS DRUGBANK
FDA_UNII_CODE GN83C131XS NDFRT
HN Introduced 2000. AOD
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. NDFRT
MESH_DUI D004809 NDFRT
MESH_NAME Ephedrine NDFRT
MESH_UI M0007539 NDFRT
MMR 20160705 MSH
MN D02.033.100.624.302 MSH
MN D02.033.755.624.302 MSH
MN D02.092.063.624.302 MSH
MN D02.092.471.683.430 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006173 NDFRT
NUI N0000147478 NDFRT
PA D000697 MSH
PA D013566 MSH
PA D014662 MSH
PA D018663 MSH
RN GN83C131XS MSH
RR 299-42-3 (Ephedrine) MSH
RR NLJ6390P1Z MSH
RR U6X61U5ZEG MSH
RXAUI 119608 RXNORM
RXAUI 2070732 RXNORM
RXAUI 3090838 RXNORM
RXAUI 3150718 RXNORM
RXAUI 3150719 RXNORM
RXAUI 3154612 RXNORM
RXAUI 3154617 RXNORM
RXAUI 3155323 RXNORM
RXAUI 3737117 RXNORM
RXAUI 6395336 RXNORM
RXAUI 6395360 RXNORM
RXAUI 6396229 RXNORM
RXCUI 3966 RXNORM
SOS From the plant Ephedra equisetina. Chemically closely related to metamphetamine. AOD
SPL_SET_ID 10816e9d-0c53-424b-b482-fdd01a4d8525 MTHSPL
SPL_SET_ID 16f212c3-d504-4d3c-813e-cc23a04aaa88 MTHSPL
SPL_SET_ID 172e970d-6773-4796-a280-3370e2f46c69 MTHSPL
SPL_SET_ID 25828db2-4942-4f7c-a0d5-dc66f82cfb71 MTHSPL
SPL_SET_ID 2ebf2fd8-767a-4983-ae6d-9912a43fe0e4 MTHSPL
SPL_SET_ID 3476ce0f-9706-4f7e-a1fd-7d7a83eaa1d8 MTHSPL
SPL_SET_ID 46633af4-98c1-471f-9232-d719c6d8e445 MTHSPL
SPL_SET_ID 699e7629-5e8a-4dac-b494-fe42698ee460 MTHSPL
SPL_SET_ID 750f9a39-acdc-4abc-800e-467884a4dcea MTHSPL
SPL_SET_ID 9005482c-25ae-d365-33d1-29269532c74d MTHSPL
SPL_SET_ID a7a2351e-f03f-442c-872c-1bec67ebf333 MTHSPL
SPL_SET_ID ae36d019-6ab6-4c13-abd9-a7665b775b84 MTHSPL
SPL_SET_ID b63d6ef1-ccce-4cd7-80f7-6d674dbf432f MTHSPL
SPL_SET_ID bb575c04-c4cd-4329-9b73-b4890305646b MTHSPL
SPL_SET_ID e4a4021c-c092-41bf-91ed-ef483fd52732 MTHSPL
SPL_SET_ID e66f4427-30fd-4c32-a9f0-29ce59b7a119 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01D6 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWv4 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T014666 MSH
TERMUI T683552 MSH
TH FDA SRS (2014) MSH
TH NLM (2008) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1889^Active/Master NDFRT
VANDF_RECORD 50.6^32^Active/Master NDFRT
VUID 4019279 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0014479

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