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Acute Disseminated Encephalomyelitis (CUI C0014059) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0014059

NCI Thesaurus Code: C34578  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An inflammatory process affecting the central nervous system. It is characterized by perivascular demyelination. Symptoms usually follow an acute viral infection or immunization and include fever, confusion, somnolence and involuntary movements. It may lead to coma and death.

RADLEX Definition: An acute or subacute inflammatory process of the central nervous system characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include confusion, somnolence, fever, nuchal rigidity, and involuntary movements. The illness may progress to coma and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921) [MeSH]

GARD Definition: Acute disseminated encephalomyelitis (ADEM) is a neurological condition characterized by a brief but intense attack of inflammation in the brain and spinal cord that damages myelin - the protective covering of nerve fibers.  It often follows viral infection, or less often, vaccination for measles, mumps, or rubella. Treatment for ADEM is targeted at suppressing inflammation in the brain using anti-inflammatory drugs. Plasmapheresis or intravenous immunoglobulin therapy may also be used.  Additional treatment is symptomatic and supportive.   - this information is from GARD/ORDR/NCATS.

NICHD Definition: Transitory inflammation of the brain and spinal cord that is associated with demyelination with or without neuronal damage.

MSH Definition: An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)

Synonyms & Abbreviations: (see Synonym Details)
ACUTE DISSEM ENCEPH
acute disseminated encephalitis
Acute Disseminated Encephalomyelitides
Acute disseminated encephalomyelitis (disorder)
Acute disseminated encephalomyelitis
ADEM - Acute disseminated encephalomyelitis
ADEM
ADE
Akute disseminierte Enzephalomyelitis
DISSEM ENCEPH ACUTE
Disseminated Encephalomyelitides, Acute
Disseminated Encephalomyelitis, Acute
ENCEPH ACUTE DISSEM
Encephalomyelitides, Acute Disseminated
Encephalomyelitis, Acute Disseminated [Disease/Finding]
Encephalomyelitis, Acute Disseminated
ENCEPHALOMYELITIS, DISSEMINATED, ACUTE
MYELINOCLASIS, PERIVASCULAR, ACUTE

External Source Codes: 
NCI Thesaurus Code C34578 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN when post-vaccinal (note X ref) coord IM with vaccine source if pertinent (IM or NIM); for post-vaccinal or postinfectious inflammation of the spinal cord only, use MYELITIS, TRANSVERSE; DF: ENCEPH ACUTE DISSEM MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X001c SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0944-4849 CSP
DID 2042-4989 CSP
DISEASE_IDENTIFIER_ID 3256 GARD
DISEASE_IDENTIFIER_ID 3257 GARD
DISEASE_IDENTIFIER_ID 34187 GARD
DX 19950101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1995; was ENCEPHALITIS, POST-VACCINAL 1963-94 MSH
IAN DEFAULT ICD10
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Encephalitis postimmunization ICD10
INCLUSION_TERM Encephalomyelitis postimmunization ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921) NDFRT
MESH_DUI D004673 NDFRT
MESH_NAME Encephalomyelitis, Acute Disseminated NDFRT
MESH_UI M0007358 NDFRT
MMR 20130708 MSH
MN C10.114.375.225 MSH
MN C10.228.140.695.562.225 MSH
MN C10.314.350.225 MSH
MN C20.111.258.250.350 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Acute Disseminated Encephalomyelitis NCI
NUI N0000001080 NDFRT
PM 1995; was ENCEPHALITIS, POST-VACCINAL 1963-94 MSH
PRIMARY_PATH 10000709$10012302$10012303$10029205$Acute disseminated encephalomyelitis$Demyelinating disorders NEC$Demyelinating disorders$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/8639/acute-disseminated-encephalomyelitis/resources/1 GARD
RXAUI 3105983 RXNORM
RXAUI 3148740 RXNORM
RXAUI 3153781 RXNORM
RXAUI 3153782 RXNORM
RXCUI 1027203 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 83942000 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G04.0 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G04.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G04.00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ACUTE DISSEMINATED ENCEPHALOMYELITIS FOLLOWING INFECTIOUS DISEASE CHOOSE G04.01 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ACUTE HEMORRHAGIC LEUKOENCEPHALITIS CHOOSE G36.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 182961000119101 | Acute disseminated encephalomyelitis following infectious disease | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 72986009 | Acute hemorrhagic leukoencephalitis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G04.00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G04.01 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G36.1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X001c SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T014310 MSH
TERMUI T014311 MSH
TERMUI T014312 MSH
TH NLM (1966) MSH
TH NLM (1995) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0014059

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