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Dopamine (CUI C0013030) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0013030

NCI Thesaurus Code: C62025  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.

CSP Definition: one of the catecholamine neurotransmitters in the brain; it is derived from tyrosine and is the precursor to norepinephrine and epinephrine; dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement; dopamine receptors mediate its action.

MSH Definition: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Synonyms & Abbreviations: (see Synonym Details)
1,2-Benzenediol, 4-(2-aminoethyl)-
2-(3,4-Dihydroxyphenyl)ethylamine
3,4 Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine
3-Hydroxytyramine
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
Dopamina
Dopamine (substance)
Dopamine [Chemical/Ingredient]
Dopamine agent
dopamine
Dopaminum
Dopamin
Dophamine
Hydroxytyramine
Hydroxytyramin
Oxytyramine
Product containing dopamine (medicinal product)
Product containing dopamine

External Source Codes: 
NCI Thesaurus Code C62025 (see NCI Thesaurus info)
CAS Registry Number 51-61-6 (see NLM ChemIDplus info)
FDA UNII Code VTD58H1Z2X

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Gray's 99:936, 937 tbl.8.1; Burt 93:100,101 fig.5-6 FMA
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:18243 NCI
Chemical_Formula C8H11NO2 NCI
Contributing_Source FDA NCI
CTV3ID x01D5 SNOMEDCT_US
CTV3ID XUc0h SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2268-5256 CSP
DX 19660101 MSH
EC agonists:Dopamine Agonists MSH
EC antagonists & inhibitors:Dopamine Antagonists MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FDA_UNII_CODE VTD58H1Z2X DRUGBANK
FDA_UNII_CODE VTD58H1Z2X NDFRT
FX D007980 MSH
FX D011954 MSH
FX D015259 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. NDFRT
MESH_DUI D004298 NDFRT
MESH_NAME Dopamine NDFRT
MESH_UI M0006756 NDFRT
MMR 20130708 MSH
MN D02.092.211.215.311.342 MSH
MN D02.092.311.342 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006091 NDFRT
NUI N0000147825 NDFRT
PA D002316 MSH
PA D013566 MSH
PA D015259 MSH
RN VTD58H1Z2X MSH
RR 51-61-6 (Dopamine) MSH
RR 62-31-7 (HCl) MSH
RR 7L3E358N9L MSH
RXAUI 109203 RXNORM
RXAUI 2070293 RXNORM
RXAUI 3091072 RXNORM
RXAUI 3093117 RXNORM
RXAUI 3093535 RXNORM
RXAUI 3142458 RXNORM
RXAUI 3142459 RXNORM
RXAUI 3148987 RXNORM
RXAUI 3149027 RXNORM
RXAUI 3174126 RXNORM
RXAUI 3631424 RXNORM
RXAUI 3737115 RXNORM
RXAUI 4618277 RXNORM
RXCUI 3628 RXNORM
SID APRD00085 DRUGBANK
SPL_SET_ID 0012578b-66ff-49a8-8415-693c68ab9c16 MTHSPL
SPL_SET_ID 0735b8c0-fd9c-4154-9a08-8c2d2200ec93 MTHSPL
SPL_SET_ID 08f23f6e-150d-45ea-098e-f2edf64c21a1 MTHSPL
SPL_SET_ID 0a3a7be8-9599-4575-9f42-46db21a57637 MTHSPL
SPL_SET_ID 0b94f4c6-7907-4162-ab8f-15e881adcfa5 MTHSPL
SPL_SET_ID 0be9304a-c45d-4369-9683-f1e33b60e97f MTHSPL
SPL_SET_ID 10007c6a-1e22-4221-bde7-ff8e63ab9adc MTHSPL
SPL_SET_ID 11c56d03-d663-47b0-ac5a-f4ed3ba7f46b MTHSPL
SPL_SET_ID 136c7284-a762-4b78-ab26-f6b236565b8b MTHSPL
SPL_SET_ID 160afc8d-b485-41ac-97ad-96f567ace387 MTHSPL
SPL_SET_ID 1b382419-e08b-4d42-b963-ba534158a72a MTHSPL
SPL_SET_ID 1cf3d712-0fd9-4ec7-b7a8-5285e81bd30e MTHSPL
SPL_SET_ID 1f306ad2-3606-4525-5a8a-ce78f426c1a2 MTHSPL
SPL_SET_ID 24497d6b-3495-47da-ab3c-3645708525fb MTHSPL
SPL_SET_ID 2801988f-18a8-491b-b7fd-132dedc3e4c6 MTHSPL
SPL_SET_ID 2c959c56-f439-446f-b0b7-9729a985bf3c MTHSPL
SPL_SET_ID 2e456b07-8b7b-463a-8cf5-1d7a51985b06 MTHSPL
SPL_SET_ID 34e283a5-ac21-4899-9524-ff5aaddbb436 MTHSPL
SPL_SET_ID 350f76f7-a6de-48b9-a09a-847ba4041180 MTHSPL
SPL_SET_ID 389c57fd-b4cf-4997-a350-043c131cbfc4 MTHSPL
SPL_SET_ID 420f6278-514e-4054-8ac0-b934c2f4d241 MTHSPL
SPL_SET_ID 458264ac-411a-4f2f-8393-7a5cb8459f27 MTHSPL
SPL_SET_ID 4b5af55d-98f9-477d-9815-5cb67e44bfbf MTHSPL
SPL_SET_ID 4c9bbe4f-44ae-4f99-8371-a607d81cc8cd MTHSPL
SPL_SET_ID 5346622d-9719-493a-90f4-21f540d6cb2a MTHSPL
SPL_SET_ID 576e3499-260b-4cc9-87c8-b54375719dd3 MTHSPL
SPL_SET_ID 57c8ec91-5103-4e6f-a678-efa4d55145ae MTHSPL
SPL_SET_ID 59a111c0-b728-4f33-8528-4cb09ecf5ae3 MTHSPL
SPL_SET_ID 5c8f36b2-aec3-442a-bc13-d454a0de252b MTHSPL
SPL_SET_ID 64d8e280-2801-4450-a23b-8ffe5980a456 MTHSPL
SPL_SET_ID 6b88d0bc-94aa-4faa-b053-f1fb248395d5 MTHSPL
SPL_SET_ID 71dd67d4-d627-4fa0-a4d4-decc44aabd2c MTHSPL
SPL_SET_ID 72b6a8ee-2aca-4fd3-84a5-81308309c8a3 MTHSPL
SPL_SET_ID 72f928e4-ad41-458e-951f-ccfebf8f4615 MTHSPL
SPL_SET_ID 7665d5a4-06d5-4d78-b7a9-481512b8a5ef MTHSPL
SPL_SET_ID 7805055c-e5f6-4d1d-9449-a5dce8a066eb MTHSPL
SPL_SET_ID 787ebb96-e635-4d45-a2b0-414bf848d862 MTHSPL
SPL_SET_ID 8435a842-56dd-41d9-be94-2817f83a42cb MTHSPL
SPL_SET_ID 8916cefd-7402-48e0-ac68-7df41a60dd60 MTHSPL
SPL_SET_ID 89ef0203-5cb0-4c18-bfa4-e23e4f52d812 MTHSPL
SPL_SET_ID 8dad8b3b-cd49-4eca-8cde-8b1f6ef7b358 MTHSPL
SPL_SET_ID 91916d24-940c-4f6c-85ef-f1524f1db5c7 MTHSPL
SPL_SET_ID 95847943-18f0-da6a-f5d3-2561b44ed16e MTHSPL
SPL_SET_ID 9a6e03db-8b02-4e7c-8148-90c155cd6a66 MTHSPL
SPL_SET_ID a0bc26cf-549e-4078-ab95-0f48c72a776e MTHSPL
SPL_SET_ID a3765689-ef84-4244-8645-57a24f7e30d3 MTHSPL
SPL_SET_ID a6feaedd-9044-42d8-9bb7-63ee3d3094a1 MTHSPL
SPL_SET_ID a9b4ab7b-1116-493b-bd27-03b42a7306d1 MTHSPL
SPL_SET_ID ac9554a1-79a8-485e-b756-ffb72ee4b175 MTHSPL
SPL_SET_ID ae6f0fd2-5f5e-447f-b749-e610cb34e53e MTHSPL
SPL_SET_ID b9974633-f293-4dd0-a3c6-769c154bd082 MTHSPL
SPL_SET_ID bd9698e8-1f5e-4881-8b58-beb6b632198e MTHSPL
SPL_SET_ID c7333b98-7e70-40a7-bf06-b2c0b4e74708 MTHSPL
SPL_SET_ID ca3c681c-5e5b-34d0-5917-549529afa65d MTHSPL
SPL_SET_ID cb97d4a0-89ed-407c-a763-209386b6f75c MTHSPL
SPL_SET_ID cc1f7c53-0023-4184-a0bc-3262884d8c1d MTHSPL
SPL_SET_ID d10ca5bc-2612-4589-a49c-1b9935fa0bf3 MTHSPL
SPL_SET_ID d76ebb82-bc6b-47fc-9a32-58357a43e783 MTHSPL
SPL_SET_ID dd6b7ad0-0dca-40a0-9b38-5856f1893281 MTHSPL
SPL_SET_ID e03becf9-dd73-48fc-9faa-90d8243c725b MTHSPL
SPL_SET_ID e061fb3e-afd7-4188-b5fb-617ac1d3e38d MTHSPL
SPL_SET_ID e2cab1bd-4d4b-4a5e-619f-04f8331ab6f9 MTHSPL
SPL_SET_ID e96ed884-239a-4676-aa3c-a472d8e23a61 MTHSPL
SPL_SET_ID e9843cd3-de60-427c-80e8-7a2a8873b146 MTHSPL
SPL_SET_ID ea27e0e2-7577-4521-acfd-696b51bff1d4 MTHSPL
SPL_SET_ID eeb20562-3b70-4c3c-a28a-fa8b657c9413 MTHSPL
SPL_SET_ID f13a92ec-bb94-4ebd-acaa-b9ad14d67cac MTHSPL
SPL_SET_ID fbfd712e-8162-488a-9caa-5d82762fb217 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01D5 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUc0h SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T013137 MSH
TERMUI T013138 MSH
TERMUI T013139 MSH
TERMUI T013141 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA
VANDF_RECORD 50.416^2352^Active/Master NDFRT
VANDF_RECORD 50.6^981^Active/Master NDFRT
VUID 4019733 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0013030

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