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Disseminated Intravascular Coagulation (CUI C0012739) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0012739

NCI Thesaurus Code: C2992  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage.

HPO Definition: Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels. [HPO:probinson, pmid:10451465, pmid:11816725]

FDA Definition: A disorder characterized by reduction in the elements involved in blood coagulation due to their utilization in widespread blood clotting within the vessels.

CTCAE Definition: A disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.

NICHD Definition: Excessive activation of the body's coagulation system resulting in systemic microvascular thrombi formation.

CSP Definition: disorder characterized by reduction in the elements involved in blood coagulation due to their utilization in widespread blood clotting within the vessels; the activation of the clotting mechanism may arise from any of a number of disorders; in the late stages, it is marked by profuse hemorrhaging.

MSH Definition: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.

Synonyms & Abbreviations: (see Synonym Details)
COAG DISSEM INTRAVASC
Coagulation (DIC), Disseminated Intravascular
Coagulation, Disseminated Intravascular
Coagulation, Intravascular Disseminated
Coagulations, Disseminated Intravascular
Coagulations, Intravascular Disseminated
Coagulopathies, Consumption
Coagulopathy, Consumption
Consumption Coagulopathies
CONSUMPTION COAGULOPATHY
Consumptive coagulopathy
Consumptive thrombohaemorrhagic disorder
Consumptive thrombohemorrhagic disorder
DEFIBRINATION SYNDROME
DIC - Disseminated intravascular coagulation
DIC SYNDROME
DIC, Disseminated Intravascular Coagulation
DIC
Diffuse or disseminated intravascular coagulation
DISSEM COAG INTRAVASC
DISSEM INTRAVASC COAG
Dissem. intravasc. coagulation
Disseminated Coagulation, Intravascular
Disseminated Coagulations, Intravascular
Disseminated intravacular coagulation
Disseminated Intravascular Coagulation (DIC)
Disseminated intravascular coagulation (disorder)
Disseminated intravascular coagulation [defibrination syndrome]
Disseminated Intravascular Coagulation [Disease/Finding]
Disseminated Intravascular Coagulations
disseminated intravascular coagulation
Haemorrhagic fibrinogenolysis
Hemorrhagic fibrinogenolysis
INTRAVASC COAG DISSEM
INTRAVASC DISSEM COAG
Intravascular Coagulation (DIC), Disseminated
Intravascular Coagulation, Disseminated
Intravascular Coagulations, Disseminated
Intravascular Disseminated Coagulations
Intravascular Disseminated Coagulation

External Source Codes: 
NCI Thesaurus Code C2992 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with ERYTHROCYTE AGGREGATION, INTRAVASCULAR; DF: DISSEM INTRAVASC COAG MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source CTCAE NCI
Contributing_Source FDA NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID D306. SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0438-8377 CSP
DX 19720101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 abortion or ectopic or molar pregnancy (O00-O07, O08.1) ICD10CM
EXCLUDES1 disseminated intravascular coagulation (complicating): ICD10CM
EXCLUDES1 in newborn (P60) ICD10CM
EXCLUDES1 pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3) ICD10CM
FDA_Table Patient Code (Appendix B) NCI
FX D055665 MSH
HN 72(70) MSH
HPO_COMMENT DIC is a complex syndrome in which there is pathological generation of thrombin and diffuse intravascular clot formation. DIC may occur as acute decompensated or chronic compensated form. In acute decompensated DIC, there is a sudden massive exposure of tissue factor over a brief time period; Intravascular coagulation can also compromise the blood supply to organs and, in conjunction with hemodynamic and metabolic derangements, may contribute to the failure of multiple organs. At the same time, the use and subsequent depletion of platelets and coagulation proteins resulting from the ongoing coagulation may induce severe bleeding. Chronic DIC, also known as compensated DIC, results from a persistent weak or intermittent activating stimulus. Under such conditions, destruction and production of coagulation factors and platelets are balanced. HPO
IAN DEFAULT ICD10
ICE Afibrinogenemia, acquired; Consumption coagulopathy; Diffuse or disseminated intravascular coagulation [DIC syndrome]; Fibrinolytic hemorrhage, acquired; Hemorrhagic fibrinogenolysis; Pathologic fibrinolysis; Purpura: {fibrinolytic; fulminans} ICD9CM
INCLUSION_TERM Afibrinogenaemia, acquired ICD10
INCLUSION_TERM Consumption coagulopathy ICD10
INCLUSION_TERM Diffuse or disseminated intravascular coagulation [DIC] ICD10
INCLUSION_TERM Fibrinolytic haemorrhage, acquired ICD10
INCLUSION_TERM Purpura: fibrinolytic ICD10
INCLUSION_TERM Purpura: fulminans ICD10
MDA 19990101 MSH
MESH_DEFINITION A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS. NDFRT
MESH_DUI D004211 NDFRT
MESH_NAME Disseminated Intravascular Coagulation NDFRT
MESH_UI M0006587 NDFRT
MMR 20080708 MSH
MN C15.378.100.220 MSH
MN C15.378.463.250 MSH
MN C15.378.925.220 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Disseminated Intravascular Coagulation NCI
NUI N0000000985 NDFRT
ORDER_NO 03448 ICD10CM
PM 72 MSH
PRIMARY_PATH 10013442$10053567$10064477$10005329$Disseminated intravascular coagulation$Coagulopathies$Coagulopathies and bleeding diatheses (excl thrombocytopenic)$Blood and lymphatic system disorders MDR
PRIMARY_SOC 10005329 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3134098 RXNORM
RXAUI 3135524 RXNORM
RXAUI 3148737 RXNORM
RXAUI 3148741 RXNORM
RXAUI 3148742 RXNORM
RXAUI 3182722 RXNORM
RXAUI 3182724 RXNORM
RXCUI 986117 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 67406007 NDFRT
SOS Excludes: that complicating: {abortion (634-638 with .1, 639.1); pregnancy or the puerperium (641.3, 666.3)}; disseminated intravascular coagulation in newborn (776.2) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS D65 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~D65 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS D65 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 29.0 DAYS CHOOSE P60 | DESCENDANTS NOT EXHAUSTIVELY MAPPED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | < 29.0 days SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~D65 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~P60 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~D306. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T012786 MSH
TERMUI T012787 MSH
TERMUI T012788 MSH
TERMUI T012789 MSH
TERMUI T012790 MSH
TERMUI T012791 MSH
TH NLM (1970) MSH
TH NLM (1992) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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