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Disopyramide (CUI C0012702) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0012702

NCI Thesaurus Code: C61730  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A class IA anti-arrhythmic agent with cardiac depressant property. Disopyramide blocks the fast sodium channel in normal cardiac cell membranes within atrial and ventricular tissues. This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity. Further, disopyramide directly decreases the rate of diastolic (phase 4) depolarization in cells with normal or augmented automaticity. Disopyramide also blocks potassium channel and results in prolonged QT interval, thus increases the effective refractory period. This agent also possesses anticholinergic property.

CSP Definition: class I antiarrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane stabilizing agent) with a depressant action on the heart similar to that of guanidine; it also possesses some anticholinergic and local anesthetic properties.

MSH Definition: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

Synonyms & Abbreviations: (see Synonym Details)
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-
Diisopyramide
Disopiramida
Disopyramide (substance)
Disopyramide [Chemical/Ingredient]
disopyramide
Disopyramidum
Product containing disopyramide (medicinal product)
Product containing disopyramide

External Source Codes: 
NCI Thesaurus Code C61730 (see NCI Thesaurus info)
CAS Registry Number 3737-09-5 (see NLM ChemIDplus info)
FDA UNII Code GFO928U8MQ

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:4657 NCI
Chemical_Formula C21H29N3O NCI
Contributing_Source FDA NCI
CTV3ID bc2.. SNOMEDCT_US
CTV3ID XUW1i SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2509-4924 CSP
DX 19840101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE GFO928U8MQ DRUGBANK
FDA_UNII_CODE GFO928U8MQ NDFRT
HN 84(72); was see under PYRIDINES 1972-83 (Prov 1972-74) MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. NDFRT
MESH_DUI D004206 NDFRT
MESH_NAME Disopyramide NDFRT
MESH_UI M0006581 NDFRT
MMR 20160531 MSH
MN D03.383.725.227 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005784 NDFRT
NUI N0000147821 NDFRT
PA D000889 MSH
PA D061567 MSH
PM 84; was see under PYRIDINES 1975-83 MSH
RN GFO928U8MQ MSH
RR 108609-26-3 MSH
RR 22059-60-5 (Disopyramide Phosphate) MSH
RR 3737-09-5 (Disopyramide) MSH
RR 54687-36-4 MSH
RR 74427-45-5 MSH
RR 74427-46-6 MSH
RR 74464-83-8 MSH
RR 74464-84-9 MSH
RR 74497-00-0 MSH
RR 79190-73-1 MSH
RR 79200-58-1 MSH
RR 79200-59-2 MSH
RR 87367-28-0 MSH
RR 87367-29-1 MSH
RR N6BOM1935W MSH
RXAUI 106675 RXNORM
RXAUI 2070257 RXNORM
RXAUI 3092658 RXNORM
RXAUI 3141540 RXNORM
RXAUI 3141541 RXNORM
RXAUI 3147062 RXNORM
RXAUI 3148421 RXNORM
RXAUI 3148425 RXNORM
RXAUI 6395274 RXNORM
RXAUI 6395312 RXNORM
RXAUI 6396207 RXNORM
RXCUI 3541 RXNORM
SID APRD00507 DRUGBANK
SPL_SET_ID 11a68e26-d2e4-48f6-ba0f-9bdd5778f25a MTHSPL
SPL_SET_ID 3b95acd8-1cce-4b76-9cb2-6e9ea40e54b1 MTHSPL
SPL_SET_ID 4c02f1b8-4493-429c-b9f7-21f364e330f8 MTHSPL
SPL_SET_ID 9a5bf15c-cb50-78b6-1a2d-8924d904d351 MTHSPL
SPL_SET_ID aee41c2f-dfe7-4f7b-85bc-04dda0915c27 MTHSPL
SPL_SET_ID cdf8d8a6-b524-491f-b7c1-0d23c77abbcd MTHSPL
SPL_SET_ID d4d3d3ce-7986-4592-ae11-17d2b2008372 MTHSPL
SPL_SET_ID e2aa1642-d262-4520-bc6a-9fd3ad795677 MTHSPL
SPL_SET_ID ee7d47d9-1900-4040-92ca-04fe1078defb MTHSPL
SPL_SET_ID f5e0c230-db38-4476-8357-9a227ccff1bc MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~bc2.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUW1i SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T012770 MSH
TERMUI T012773 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USAN (1970) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2348^Active/Master NDFRT
VANDF_RECORD 50.6^206^Active/Master NDFRT
VUID 4019729 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0012702

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