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Diphtheria (CUI C0012546) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0012546

NCI Thesaurus Code: C34541  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.

MEDLINEPLUS Definition: 

Diphtheria is a serious bacterial infection. You can catch it from a person who has the infection and coughs or sneezes. You can also get infected by coming in contact with an object, such as a toy, that has bacteria on it.

Diphtheria usually affects the nose and throat. Symptoms include

  • Sore throat
  • Swollen glands in the neck
  • Fever
  • Weakness

Your doctor will diagnose it based on your signs and symptoms and a lab test. Getting treatment for diphtheria quickly is important. If your doctor suspects that you have it, you'll start treatment before the lab tests come back. Treatment is with antibiotics.

The diphtheria, pertussis, and tetanus (DPT) vaccine can prevent diphtheria, but its protection does not last forever. Children need another dose, or booster, at about age 12. Then, as adults, they should get a booster every 10 years. Diphtheria is very rare in the United States because of the vaccine.

Centers for Disease Control and Prevention

NICHD Definition: A toxicoinfection that is caused by Corynebacterium diphtheriae; it predominantly involves the upper respiratory tract, where pseudomembranes are characteristic. Cutaneous diphtheria, toxic myocardiopathy, and toxic neuropathy also can occur.

CSP Definition: localized infection of mucous membranes or skin caused by toxigenic strains of Corynebacterium diphtheriae; it is characterized by the presence of a pseudomembrane at the site of infection; diphtheria toxin, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.

MSH Definition: A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.

Synonyms & Abbreviations: (see Synonym Details)
Corynebacterium diphtheriae infection
Diphtheria (disorder)
Diphtheria [Disease/Finding]
Diphtheria NOS
Diphtheria, unspecified
Diphtherias
diphtheria
Infection caused by Corynebacterium diphtheriae (disorder)
Infection caused by Corynebacterium diphtheriae
Infection due to Corynebacterium diphtheriae

External Source Codes: 
NCI Thesaurus Code C34541 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN caused by Corynebacterium diphtheriae MSH
ANSWER_CODE 10040 LNC
ANSWER_CODE_SYSTEM NNDSS LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID XSC9E SNOMEDCT_US
CTV3ID XUYJT SNOMEDCT_US
DATE_CREATED 08/07/2001 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 0368-2696 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20090731 SNOMEDCT_US
EFFECTIVE_TIME 20150731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects. NDFRT
MESH_DUI D004165 NDFRT
MESH_NAME Diphtheria NDFRT
MESH_UI M0006520 NDFRT
MMR 19950525 MSH
MN C01.252.410.040.246.388 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/diphtheria.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Farsi https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Farsi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hmong https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Hmong MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Portuguese https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Portuguese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/diphtheria.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Tagalog https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Tagalog MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Thai https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Thai MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Turkish https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Turkish MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Vietnamese https://www.nlm.nih.gov/medlineplus/languages/diphtheria.html#Vietnamese MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Diphtheria NCI
NUI N0000000977 NDFRT
ORDER_NO 00240 ICD10CM
ORDER_NO 00253 ICD10CM
PRIMARY_PATH 10013023$10011210$10004018$10021881$Diphtheria$Corynebacteria infections$Bacterial infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/1875/diphtheria/resources/1 GARD
RXAUI 3147407 RXNORM
RXAUI 3147419 RXNORM
RXCUI 1023500 RXNORM
SNOMED_CID 276197005 NDFRT
SNOMED_CID 397428000 NDFRT
SOS Includes: infection by Corynebacterium diphtheriae ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS A36.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~A36.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS A36.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS A36.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A36.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XSC9E SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUYJT SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T012655 MSH
TH POPLINE (1994) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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