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Dimethyl Sulfoxide (CUI C0012403) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0012403

NCI Thesaurus Code: C437  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger. It shows a range of pharmacological activity including analgesia and anti-inflammation. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect cells and tissue during cryopreservation and has been used to treat extravasation damage caused by anthracycline-based chemotherapy.

PDQ Definition: A polar organic solvent. DMSO is a free radical scavenger that has been used to treat extravasation damage caused by anthracycline-based chemotherapy. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A colorless liquid that readily dissolves many chemicals and penetrates animal and plant tissues. It is used in human medicine, veterinary medicine, and pharmaceuticals.

CSP Definition: highly polar organic liquid, that is used widely as a chemical solvent; because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals; it is also used to protect tissue during cryopreservation; dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

MSH Definition: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

Synonyms & Abbreviations: (see Synonym Details)
(CH3)2SO
(DMSO)
3211
67-68-5
763
Demasorb
Demeso
Dimethyl Sulfoxide [Chemical/Ingredient]
Dimethyl sulfoxide product (product)
Dimethyl sulfoxide product
Dimethyl Sulfoxide
Dimethyl sulfur oxide
Dimethyl sulphoxide product
Dimethyl sulphoxide
Dimethyli sulfoxidum
Dimethylsulfoxide (substance)
dimethylsulfoxide
Dimethylsulfoxid
Dimethylsulfoxyde
Dimethylsulphinyl
Dimethylsulphoxide
Dimetil sulfoxido
DMSO - Dimethylsulfoxide
DMSO - Dimethylsulphoxide
DMSO
Domoso
Dromisol
Methane, sulfinylbis-
Methylsulfinylmethane
S(O)Me2
SQ 9453
SQ-9453
Sulfinylbis(methane)
Sulfinylbismethane
Sulfoxide, Dimethyl
Sulphoxide, Dimethyl

External Source Codes: 
NCI Thesaurus Code C437 (see NCI Thesaurus info)
CAS Registry Number 67-68-5 (see NLM ChemIDplus info)
FDA UNII Code YOW8V9698H
NSC Code 763 (see NCI DTP info)
PDQ Closed Trial Search ID 39222
PDQ Open Trial Search ID 39222 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:28262 NCI
Chemical_Formula C2H6OS NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID x0030 SNOMEDCT_US
CTV3ID XM0li SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2841-9966 CSP
DX 19650101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE YOW8V9698H DRUGBANK
FDA_UNII_CODE YOW8V9698H NDFRT
HN 65(64) MSH
LEVEL Ingredient NDFRT
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. NDFRT
MESH_DUI D004121 NDFRT
MESH_NAME Dimethyl Sulfoxide NDFRT
MESH_UI M0006456 NDFRT
MMR 20160705 MSH
MN D02.886.640.150 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C437 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006711 NDFRT
NUI N0000147300 NDFRT
ORIG_STY Drug/agent PDQ
PA D003451 MSH
PA D012997 MSH
PA D016166 MSH
PID 1844 PDQ
PM 65 MSH
RN YOW8V9698H MSH
RR 67-68-5 (Dimethyl Sulfoxide) MSH
RXAUI 104460 RXNORM
RXAUI 2070235 RXNORM
RXAUI 3030972 RXNORM
RXAUI 3141199 RXNORM
RXAUI 3141200 RXNORM
RXAUI 3141780 RXNORM
RXAUI 3147123 RXNORM
RXAUI 3147124 RXNORM
RXAUI 3147125 RXNORM
RXAUI 3147172 RXNORM
RXAUI 3147173 RXNORM
RXAUI 3147174 RXNORM
RXAUI 3198215 RXNORM
RXAUI 3241474 RXNORM
RXAUI 4232487 RXNORM
RXAUI 4238328 RXNORM
RXAUI 6800444 RXNORM
RXCUI 1592760 RXNORM
RXCUI 3455 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00925 DRUGBANK
SID EXPT01231 DRUGBANK
SNOMEDID C-22047 SNOMEDCT_US
SNOMEDID C-780ED SNOMEDCT_US
SPL_SET_ID 00e64e31-e674-4d8f-9b68-a14b7002386f MTHSPL
SPL_SET_ID 0512c887-0b32-4a4c-9c88-2f8df6d1d82a MTHSPL
SPL_SET_ID 05742cd5-ece2-4007-bdf0-46b76d23df74 MTHSPL
SPL_SET_ID 06667c3a-7513-44b3-8cd0-268c14436ae7 MTHSPL
SPL_SET_ID 1279c031-106f-44a5-9e8a-da37cd9e24bd MTHSPL
SPL_SET_ID 14b76eca-29f6-4dbd-890b-f72865877ad3 MTHSPL
SPL_SET_ID 1c6c18db-5e42-4942-a611-00d49651a91f MTHSPL
SPL_SET_ID 1cfba647-929e-4525-b37a-b912a5a0ec4f MTHSPL
SPL_SET_ID 22b24f35-9ff5-4950-e054-00144ff88e88 MTHSPL
SPL_SET_ID 26411ade-7069-4f93-8833-6fb1fadd5198 MTHSPL
SPL_SET_ID 2972357d-7180-486e-b86b-5a6cf570c070 MTHSPL
SPL_SET_ID 29ea4b34-dff7-40de-82b4-9b2dd1eb32ca MTHSPL
SPL_SET_ID 2bf4bf54-b44b-489f-9f95-bb4bd270ba14 MTHSPL
SPL_SET_ID 2d61c9b9-587d-4406-bbdb-2c627cdef02f MTHSPL
SPL_SET_ID 2d8f4048-14cb-7484-e054-00144ff88e88 MTHSPL
SPL_SET_ID 2e905c1f-9022-4c07-b240-39ff7d6fb12e MTHSPL
SPL_SET_ID 2ed25286-b077-1af2-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2fbfc4ac-75a5-6e28-e054-00144ff8d46c MTHSPL
SPL_SET_ID 32813ca4-6e6e-3551-e054-00144ff88e88 MTHSPL
SPL_SET_ID 3a5e4a8e-20bb-4bf8-8a2e-8dfd7f2afb49 MTHSPL
SPL_SET_ID 3a72c7d1-910f-4830-b88f-dc9c24852388 MTHSPL
SPL_SET_ID 3d425a74-bbfc-4830-9b18-93a9eaf9578a MTHSPL
SPL_SET_ID 3d60d0f9-2d57-497d-93ae-daa2c3357a35 MTHSPL
SPL_SET_ID 3d858754-b3d0-49cb-834e-9b9a35eea0fa MTHSPL
SPL_SET_ID 3e1c5ee0-31a0-4b09-a54f-40272b572e12 MTHSPL
SPL_SET_ID 4050064a-b326-49d4-ae82-cd06d5ecb007 MTHSPL
SPL_SET_ID 43d7d5d1-a593-4b97-ae24-f3e92be90004 MTHSPL
SPL_SET_ID 4732a181-9fe0-49b4-b486-e2da9ad66e31 MTHSPL
SPL_SET_ID 4ae0564a-6c03-4848-88d0-621943d94ea1 MTHSPL
SPL_SET_ID 4bff4833-899d-4886-9df6-dd27b87cc0d2 MTHSPL
SPL_SET_ID 51b97443-5764-44c9-a2a8-cd1bc01b2c66 MTHSPL
SPL_SET_ID 57a5d86e-5fa5-4bc6-9fe9-ec7d617fadfb MTHSPL
SPL_SET_ID 588b71d3-157f-4f69-abd6-db87cb78759a MTHSPL
SPL_SET_ID 58b25d79-78f2-4953-b0c6-61658dc4ef0d MTHSPL
SPL_SET_ID 59305749-d5af-412f-93d9-c20ff73ca523 MTHSPL
SPL_SET_ID 5960adae-9ed2-469a-b092-ac977d260222 MTHSPL
SPL_SET_ID 5d260623-1e56-cacc-5df8-0841d52e6872 MTHSPL
SPL_SET_ID 5edddb99-6596-4a3b-b361-1cc04d032c31 MTHSPL
SPL_SET_ID 61744544-8bcd-4760-930a-42615e32b12b MTHSPL
SPL_SET_ID 64c67e81-dbfb-4e8a-b3ae-13ab360673ad MTHSPL
SPL_SET_ID 68739dff-2e2c-44a2-847a-3886c692dd22 MTHSPL
SPL_SET_ID 6b74d405-42d6-4c46-ba78-3007d1e8ffb8 MTHSPL
SPL_SET_ID 6f14d3bb-353d-4e03-beb7-6117a4a780bb MTHSPL
SPL_SET_ID 73315a28-a42f-414c-9121-a621ed8e587b MTHSPL
SPL_SET_ID 7445dca9-84ee-4b05-acd3-13526b7749e6 MTHSPL
SPL_SET_ID 7e765fc1-74c6-4af3-a9cf-05b57011d7d8 MTHSPL
SPL_SET_ID 80217dbb-a0f0-414a-8d22-a9a346b017aa MTHSPL
SPL_SET_ID 802cd382-443d-48e3-9c9d-fd946c73c79f MTHSPL
SPL_SET_ID 821e40a3-1c10-4069-bbbb-920fa9d35dab MTHSPL
SPL_SET_ID 82c5998f-2253-4880-9be5-feaba553d5d1 MTHSPL
SPL_SET_ID 8363f3dd-7ed3-407e-b681-3d388e8651e0 MTHSPL
SPL_SET_ID 8c7d5860-d8e9-4721-9825-f1a9b1ba18e7 MTHSPL
SPL_SET_ID 9215ec6b-69df-4b7d-b426-af50955d2c7c MTHSPL
SPL_SET_ID 9c02fe26-efe8-4bca-9f38-c0f9e22d25cf MTHSPL
SPL_SET_ID 9d7da18d-1003-4156-b28a-f9a8043ebe96 MTHSPL
SPL_SET_ID a1d90bb4-37d1-4953-8146-0e28f14b6f17 MTHSPL
SPL_SET_ID a2d89045-a178-4732-bc2d-0c27f934e538 MTHSPL
SPL_SET_ID a851ed45-38bc-499f-836b-b472f4c86ec1 MTHSPL
SPL_SET_ID a9bd1172-8d70-eb18-fb94-330f8aecd8b9 MTHSPL
SPL_SET_ID ac6b4215-c905-4f4e-9dd8-b0eb7fa4f8b6 MTHSPL
SPL_SET_ID aca9ebff-a437-48d9-8baf-06b9021a4740 MTHSPL
SPL_SET_ID b36c7977-557d-4ab4-bc4a-35875f1848e6 MTHSPL
SPL_SET_ID b73136d2-8e93-41aa-989d-9bef074f5a67 MTHSPL
SPL_SET_ID bb530269-5c2e-4821-8fca-2fea108f8f26 MTHSPL
SPL_SET_ID bbec8582-4ef0-41d3-b1eb-954ec63bfe5b MTHSPL
SPL_SET_ID bc8baceb-841a-4e6d-8cad-37cc627f50ea MTHSPL
SPL_SET_ID bd53a9e3-65c8-4834-8e23-a2a928b83a66 MTHSPL
SPL_SET_ID bd9a5180-1773-11e0-980a-0002a5d5c51b MTHSPL
SPL_SET_ID c5855fad-0acb-4e4c-b186-bc759aa503f2 MTHSPL
SPL_SET_ID c99f5ef6-c777-4896-a5e7-7335257439b2 MTHSPL
SPL_SET_ID ca63dce1-825a-4338-9c72-77d5bc8a7661 MTHSPL
SPL_SET_ID cd7f1eba-39b4-480d-ae11-57912afd2916 MTHSPL
SPL_SET_ID d36e4299-fb03-4062-97ce-e9e04cf18587 MTHSPL
SPL_SET_ID d99ef8e0-1cb2-42ea-8b38-837ce8c8e672 MTHSPL
SPL_SET_ID e0236c9d-f893-4a75-98fe-cd8ff3171eb0 MTHSPL
SPL_SET_ID ee2743ed-8002-435b-bbbc-ea8824880f62 MTHSPL
SPL_SET_ID ee94530d-f958-4a7e-9d1f-52ff55261a07 MTHSPL
SPL_SET_ID f8f10213-b92c-45ba-adf6-ebb2f91ca1a8 MTHSPL
SPL_SET_ID fae53d24-acf1-4250-888d-b8d965ffc3d3 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x0030 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0li SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-22047 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-780ED SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T012517 MSH
TERMUI T012518 MSH
TERMUI T012519 MSH
TERMUI T012521 MSH
TERMUI T012524 MSH
TERMUI T012525 MSH
TERMUI T012526 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TH USAN (1965) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1632^Active/Master NDFRT
VANDF_RECORD 50.6^1474^Active/Master NDFRT
VUID 4019027 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0012403

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