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Diazepam (CUI C0012010) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0012010

NCI Thesaurus Code: C28982  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A benzodiazepine derivative with anti-anxiety, sedative, hypnotic and anticonvulsant properties. Diazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic system and the hypothalamus. This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability.

NCI-GLOSS Definition: A drug used to treat mild to moderate anxiety and tension and to relax muscles. It is a type of benzodiazepine.

CSP Definition: benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action; its actions are mediated by enhancement of amma-aminobutyric acid activity; it is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.

MSH Definition: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

Synonyms & Abbreviations: (see Synonym Details)
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Diazepam (product)
Diazepam (substance)
Diazepam [Chemical/Ingredient]
Diazepam product
diazepam
Methyl diazepinone
Valium

External Source Codes: 
NCI Thesaurus Code C28982 (see NCI Thesaurus info)
CAS Registry Number 439-14-5 (see NLM ChemIDplus info)
FDA UNII Code Q3JTX2Q7TU
NSC Code 169897 (see NCI DTP info)
NSC Code 77518 (see NCI DTP info)
NSC Code 46083 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:49575 NCI
Chemical_Formula C16H13ClN2O NCI
Contributing_Source FDA NCI
CTV3ID x02LM SNOMEDCT_US
CTV3ID XUWtY SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0314-5175 CSP
DX 19650101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE Q3JTX2Q7TU DRUGBANK
FDA_UNII_CODE Q3JTX2Q7TU NDFRT
FX D011963 MSH
HN 65(63) MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19990101 MSH
MESH_DEFINITION A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. NDFRT
MESH_DUI D003975 NDFRT
MESH_NAME Diazepam NDFRT
MESH_UI M0006229 NDFRT
MMR 20160529 MSH
MN D03.633.100.079.080.070.216 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006321 NDFRT
NUI N0000146157 NDFRT
PA D000759 MSH
PA D000927 MSH
PA D000932 MSH
PA D006993 MSH
PA D009125 MSH
PA D014151 MSH
PA D018686 MSH
PA D018757 MSH
PM 65 MSH
RN 0 MSH
RN Q3JTX2Q7TU MSH
RR 439-14-5 (Diazepam) MSH
RXAUI 1135892 RXNORM
RXAUI 2070152 RXNORM
RXAUI 2253977 RXNORM
RXAUI 2596885 RXNORM
RXAUI 2598844 RXNORM
RXAUI 2722111 RXNORM
RXAUI 3092866 RXNORM
RXAUI 3094538 RXNORM
RXAUI 3140023 RXNORM
RXAUI 3140024 RXNORM
RXAUI 3146525 RXNORM
RXAUI 3146528 RXNORM
RXCUI 202472 RXNORM
RXCUI 3322 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00642 DRUGBANK
SID DB07699 DRUGBANK
SNOMEDID C-64555 SNOMEDCT_US
SNOMEDID R-F2B2C SNOMEDCT_US
SOS An antianxiety tranquilizer derived from benzodiazepine. AOD
SOS Manufactured as Valium. Classification: sedative/hypnotics. (RIS 27:204--9 entries) AOD
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SPL_SET_ID fa7c7ec3-1c32-4902-8625-5e09f09f44dc MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02LM SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWtY SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-64555 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R-F2B2C SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T012064 MSH
TERMUI T012065 MSH
TERMUI T012067 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH UNK (19XX) MSH
TH USAN (19XX) MSH
TH USP (1963) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^391^Active/Master NDFRT
VANDF_RECORD 50.6^167^Active/Master NDFRT
VUID 4017796 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0012010

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