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Diabetes Mellitus, Insulin-Dependent (CUI C0011854) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0011854

NCI Thesaurus Code: C2986  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

GARD Definition: Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. - this information is from GARD/ORDR/NCATS.

HPO Definition: A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin. [HPO:probinson]

MEDLINEPLUS Definition: 

Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth.

Type 1 diabetes happens most often in children and young adults but can appear at any age. Symptoms may include

  • Being very thirsty
  • Urinating often
  • Feeling very hungry or tired
  • Losing weight without trying
  • Having sores that heal slowly
  • Having dry, itchy skin
  • Losing the feeling in your feet or having tingling in your feet
  • Having blurry eyesight

A blood test can show if you have diabetes. If you do, you will need to take insulin for the rest of your life.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

NICHD Definition: Diabetes mellitus caused by cell-mediated autoimmune destruction of pancreatic beta cells.

CSP Definition: subtype of diabetes mellitus that is characterized by insulin deficiency; it is manifested by the sudden onset of severe hyperglycemia, rapid progression to diabetic ketoacidosis, and death unless treated with insulin; the disease may occur at any age, but is most common in childhood or adolescence.

MSH Definition: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Synonyms & Abbreviations: (see Synonym Details)
-- Diabetes Type 1
DIABETES MELLITUS (JUVENILE ONSET)
DIABETES MELLITUS INSULIN DEPENDENT
Diabetes mellitus insulin-dependent
Diabetes mellitus juvenile onset
DIABETES MELLITUS TYPE 01
Diabetes mellitus type 1 (disorder)
Diabetes mellitus type 1
Diabetes mellitus Type I
Diabetes Mellitus, Brittle
DIABETES MELLITUS, INSULIN DEPENDENT
Diabetes Mellitus, Insulin-Dependent, 1
Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Juvenile Onset
Diabetes Mellitus, Juvenile-Onset
Diabetes Mellitus, Ketosis Prone
Diabetes Mellitus, Ketosis-Prone
Diabetes Mellitus, Sudden Onset
Diabetes Mellitus, Sudden-Onset
Diabetes Mellitus, Type 1 [Disease/Finding]
DIABETES MELLITUS, TYPE 1
DIABETES MELLITUS, TYPE I
Diabetes Type 1
Diabetes, Juvenile-Onset
Diabetes, Type 1
IDDM1
IDDM
IDD
Immune Mediated Diabetes
Insulin Dependent Diabetes Mellitus 1
insulin dependent diabetes mellitus
insulin dependent diabetes
Insulin dependent diabetic
Insulin-dependent diabetes mellitus (type I)
Insulin-Dependent Diabetes Mellitus 1
Insulin-dependent diabetes mellitus
Insulin-dependent diabetes
JOD
juvenile diabetes mellitus
Juvenile diabetes
JUVENILE ONSET DIABETES MELLITUS
Juvenile Onset Diabetes
Juvenile-Onset Diabetes Mellitus
Juvenile-onset diabetes
ketosis prone diabetes
Ketosis-prone diabetes mellitus
KPD
Mellitus, Sudden-Onset Diabetes
Sudden-Onset Diabetes Mellitus
Type 1 diabetes mellitus
type 1 diabetes
type I diabetes mellitus
Type I Diabetes

External Source Codes: 
NCI Thesaurus Code C2986 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN MICE, INBRED NOD are a common model for this disease MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID X40J4 SNOMEDCT_US
DATE_CREATED 08/28/2000 MEDLINEPLUS
DATE_CREATED 2010-12-29T06:37:55Z HPO
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2014-01-25T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2014-01-25T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0862-6800 CSP
DISEASE_IDENTIFIER_ID 23330 GARD
DISEASE_IDENTIFIER_ID 23331 GARD
DISEASE_IDENTIFIER_ID 23332 GARD
DISEASE_IDENTIFIER_ID 23333 GARD
DISEASE_IDENTIFIER_ID 5970 GARD
DX 20050101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 diabetes mellitus due to underlying condition (E08.-) ICD10CM
EXCLUDES1 drug or chemical induced diabetes mellitus (E09.-) ICD10CM
EXCLUDES1 gestational diabetes (O24.4-) ICD10CM
EXCLUDES1 hyperglycemia NOS (R73.9) ICD10CM
EXCLUDES1 neonatal diabetes mellitus (P70.2) ICD10CM
EXCLUDES1 postpancreatectomy diabetes mellitus (E13.-) ICD10CM
EXCLUDES1 postprocedural diabetes mellitus (E13.-) ICD10CM
EXCLUDES1 secondary diabetes mellitus NEC (E13.-) ICD10CM
EXCLUDES1 type 2 diabetes mellitus (E11.-) ICD10CM
EXTERNALLY_DEFINED N LNC
FX D016688 MSH
GENELOCUS ,1,p,1,3, OMIM
GENELOCUS ,7,q,3,2, OMIM
GENESYMBOL KPD OMIM
GENESYMBOL LYP OMIM
GENESYMBOL MODY9 OMIM
GENESYMBOL PAX4 OMIM
GENESYMBOL PEP OMIM
GENESYMBOL PTPN22 OMIM
GENESYMBOL PTPN8 OMIM
HAS_GARD_PAGE true GARD
HN 2005 (1984) MSH
HPO_COMMENT The onset of type 1 diabetes is typically during adolescence, but it can develop at any age. HPO
IAN DEFAULT ICD10
IDENTIFIER_SOURCE GHR GARD
IDENTIFIER_SOURCE OMI GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM diabetes (mellitus): brittle ICD10
INCLUSION_TERM diabetes (mellitus): juvenile-onset ICD10
INCLUSION_TERM diabetes (mellitus): ketosis-prone ICD10
INCLUSION_TERM diabetes (mellitus): type I ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
LAST_REVIEW_DATE 2013-10-10T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. NDFRT
MESH_DUI D003922 NDFRT
MESH_NAME Diabetes Mellitus, Type 1 NDFRT
MESH_UI M0006152 NDFRT
MIMTYPE 3 OMIM
MIMTYPE 5 OMIM
MIMTYPEMEANING Mendelian phenotype or locus, molecular basis unknown. OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE perc OMIM
MIMTYPEVALUE pound OMIM
MMR 20160318 MSH
MN C18.452.394.750.124 MSH
MN C19.246.267 MSH
MN C20.111.327 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/diabetestype1.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/diabetestype1.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/diabetestype1.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/diabetestype1.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/diabetestype1.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/diabetestype1.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/diabetestype1.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Type 1 Diabetes Mellitus NCI
NUI N0000000952 NDFRT
ORDER_NO 03937 ICD10CM
PM 2005; see DIABETES MELLITUS, TYPE I 2004, see DIABETES MELLITUS, INSULIN-DEPENDENT 1984-2003, see DIABETES MELLITUS, JUVENILE 1966-1983 MSH
PRIMARY_PATH 10067584$10012602$10018424$10027433$Type 1 diabetes mellitus$Diabetes mellitus (incl subtypes)$Glucose metabolism disorders (incl diabetes mellitus)$Metabolism and nutrition disorders MDR
PRIMARY_SOC 10027433 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10268/diabetes-mellitus-type-1/resources/1 GARD
REF HPO:skoehler HPO
RXAUI 3146304 RXNORM
RXAUI 3146306 RXNORM
RXAUI 3146309 RXNORM
RXAUI 3146322 RXNORM
RXAUI 3146323 RXNORM
RXAUI 3146324 RXNORM
RXAUI 3146327 RXNORM
RXAUI 3175316 RXNORM
RXAUI 3251650 RXNORM
RXAUI 5039172 RXNORM
RXAUI 5039513 RXNORM
RXAUI 5039533 RXNORM
RXCUI 1024148 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 46635009 NDFRT
SNOMEDID DB-61010 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E10.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E10.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E10.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E10.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X40J4 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DB-61010 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000896379 MSH
TERMUI T011736 MSH
TERMUI T011737 MSH
TERMUI T011738 MSH
TERMUI T011739 MSH
TERMUI T011740 MSH
TERMUI T011741 MSH
TERMUI T011742 MSH
TERMUI T011743 MSH
TERMUI T578603 MSH
TERMUI T811491 MSH
TERMUI T811492 MSH
TERMUI T811493 MSH
TH NLM (1966) MSH
TH NLM (1993) MSH
TH NLM (1998) MSH
TH NLM (2005) MSH
TH NLM (2017) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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