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dehydroepiandrosterone (CUI C0011185) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0011185

NCI Thesaurus Code: C2265  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Hormone

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

PDQ Definition: A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. It is a type of steroid.

CSP Definition: major C19 steroid produced by the adrenal cortex; also produced in small quantities in the testis and the ovary; dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone; most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion.

MSH Definition: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.

Synonyms & Abbreviations: (see Synonym Details)
17-Hormoforin
3beta-Hydroxyandrost-5-en-17-one
5 Androsten 3 beta hydroxy 17 one
5,6-Dehydroisoandrosterone
5-Androsten-3-beta-hydroxy-17-one
53-43-0
9896
Androst-5-en-17-one, 3-hydroxy-, (3beta)-
androstenolone
Dehydro-3-epiandrosterone
Dehydroepiandrosterone (substance)
Dehydroepiandrosterone [Chemical/Ingredient]
Dehydroepiandrosterone preparation
dehydroepiandrosterone
Dehydroisoandrosterone
DHA - Dehydroepiandrosterone
DHEA - Dehydroepiandrosterone
DHEA
Diandron
Fidelin
GL701
prasterone
Product containing dehydroepiandrosterone (medicinal product)
Product containing dehydroepiandrosterone
Therapeutic Dehydroepiandrosterone

External Source Codes: 
NCI Thesaurus Code C2265 (see NCI Thesaurus info)
CAS Registry Number 53-43-0 (see NLM ChemIDplus info)
FDA UNII Code 459AG36T1B
NSC Code 9896 (see NCI DTP info)
PDQ Closed Trial Search ID 42419
PDQ Open Trial Search ID 42419 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction NCI
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:28689 NCI
Chemical_Formula C19H28O2 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID X80FW SNOMEDCT_US
CTV3ID XUckV SNOMEDCT_US
DATE_LAST_MODIFIED 2010-10-27 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0171-4928 CSP
DX 20040101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
FDA_UNII_CODE 459AG36T1B NDFRT
HN 2004, 1963-1992 MSH
HN Introduced 2000. AOD
LEVEL Ingredient NDFRT
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. NDFRT
MESH_DUI D003687 NDFRT
MESH_NAME Dehydroepiandrosterone NDFRT
MESH_UI M0005765 NDFRT
MMR 20160528 MSH
MN D04.210.500.054.079.429.625 MSH
MN D04.210.500.578.502.400 MSH
MN D06.472.040.502.400 MSH
MN D06.472.334.851.968.952 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C2265 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000010096 NDFRT
NUI N0000148779 NDFRT
ORIG_STY Drug/agent PDQ
PA D000276 MSH
PID 5694 PDQ
PM 2004, 1963-1992; use PRASTERONE 1993-2003 MSH
RN 459AG36T1B MSH
RR 2283-82-1 (3 alpha-isomer) MSH
RR 25375-38-6 (cpd w/o stereochem designation) MSH
RR 53-43-0 (Dehydroepiandrosterone) MSH
RXAUI 1839309 RXNORM
RXAUI 2180535 RXNORM
RXAUI 3094101 RXNORM
RXAUI 3108885 RXNORM
RXAUI 3108920 RXNORM
RXAUI 3138501 RXNORM
RXAUI 3138502 RXNORM
RXAUI 3139868 RXNORM
RXAUI 3145114 RXNORM
RXAUI 3145118 RXNORM
RXAUI 3145308 RXNORM
RXAUI 3223132 RXNORM
RXAUI 3632366 RXNORM
RXAUI 5073155 RXNORM
RXCUI 3143 RXNORM
SPL_SET_ID 01f30680-cb54-4c07-a9a6-847b453770a5 MTHSPL
SPL_SET_ID 02e3d6d8-ea32-4cfa-bd9b-0d6e72bb4552 MTHSPL
SPL_SET_ID 04daddb5-009c-46e8-96be-334e489a6d6c MTHSPL
SPL_SET_ID 13b46fd4-2908-450d-9071-ca9f48cfa7d0 MTHSPL
SPL_SET_ID 169be2ff-1622-4866-a663-5589e2362e39 MTHSPL
SPL_SET_ID 1b382419-e08b-4d42-b963-ba534158a72a MTHSPL
SPL_SET_ID 232f684a-0cff-48df-aa96-34284ccedcbb MTHSPL
SPL_SET_ID 23c93f62-14b7-0045-26ae-8844de241ed0 MTHSPL
SPL_SET_ID 27b75090-088d-4a5a-ae6b-d97a5e8c651a MTHSPL
SPL_SET_ID 2c272405-837d-007f-e054-00144ff88e88 MTHSPL
SPL_SET_ID 2d785b97-cb88-2c8d-e054-00144ff88e88 MTHSPL
SPL_SET_ID 2e77e321-a263-4918-ae40-7ca883deabbf MTHSPL
SPL_SET_ID 3615fdf9-bdc5-44ad-a9f3-cbd0ea87c4a5 MTHSPL
SPL_SET_ID 37936067-b318-4f94-a9f0-8d68e5311e09 MTHSPL
SPL_SET_ID 45ad3f03-0ee8-438f-81e7-3ca772022c98 MTHSPL
SPL_SET_ID 54e8f581-9286-4784-bd48-68f8a2e5eba4 MTHSPL
SPL_SET_ID 5d003eb5-628d-49fa-bada-569a278f1bad MTHSPL
SPL_SET_ID 615627eb-be72-4d44-9504-fbe97b652046 MTHSPL
SPL_SET_ID 61fa6e6e-42f5-4992-87b5-0770218abc8c MTHSPL
SPL_SET_ID 663affc1-0998-4231-b284-ff3e2a7807b9 MTHSPL
SPL_SET_ID 70c21d52-b73a-4d44-a08a-15b852d9307c MTHSPL
SPL_SET_ID 78f26039-fe24-43fb-99c2-4f2151f3c3ca MTHSPL
SPL_SET_ID 79f4b40c-9f93-473b-979a-6fa8ed7c30db MTHSPL
SPL_SET_ID 83a0738f-3e0b-45ea-a752-395a38043b2b MTHSPL
SPL_SET_ID 86f855eb-04dc-427c-b8be-a9d862bb06c5 MTHSPL
SPL_SET_ID 8b3af556-74fb-4054-80ca-2a973a9bc617 MTHSPL
SPL_SET_ID 8e8f1af0-ad54-4ec0-a809-2e682d1f89a7 MTHSPL
SPL_SET_ID 9a6e03db-8b02-4e7c-8148-90c155cd6a66 MTHSPL
SPL_SET_ID 9c355245-260a-464b-abcf-95416b49caa3 MTHSPL
SPL_SET_ID a11f60fb-b149-4bf6-bbbb-acd06e6b08c0 MTHSPL
SPL_SET_ID a3c6cfa5-c6f6-489e-9270-7c4dacb5fcb0 MTHSPL
SPL_SET_ID adc5473f-29e4-4025-942a-cca35cc3efdc MTHSPL
SPL_SET_ID b1971d8f-e72d-96a0-c43f-7ba0103e921e MTHSPL
SPL_SET_ID be121012-2178-494c-bbc5-62f062cb6560 MTHSPL
SPL_SET_ID bf1d82fa-6846-4aa4-9390-c4c4e7a559dd MTHSPL
SPL_SET_ID c01d363e-2ece-43dd-86b6-27e6519f37e5 MTHSPL
SPL_SET_ID c0718768-6f1f-43c2-8c91-e6c94af9d089 MTHSPL
SPL_SET_ID c7ac1e1b-a1ef-4448-9179-d4bc11fcfbda MTHSPL
SPL_SET_ID c9dbfdfa-287a-465c-b8ac-03b1dead1d54 MTHSPL
SPL_SET_ID d509cc4f-d92f-4216-a117-16b467a29126 MTHSPL
SPL_SET_ID d6edd874-495c-4eb5-bf3d-72c2ee41fc88 MTHSPL
SPL_SET_ID d9d9e08a-25b6-4f59-8534-5bb1b5fe118f MTHSPL
SPL_SET_ID e105a1c3-c896-4dfe-a403-8da7a98a5add MTHSPL
SPL_SET_ID e231695a-165a-419e-b594-34f9522503ac MTHSPL
SPL_SET_ID f04a01eb-5619-47d7-ad5c-a0c847191eb3 MTHSPL
SPL_SET_ID f5b62b9d-5750-47f6-b497-4da06000506b MTHSPL
SPL_SET_ID fa9ed512-97dc-44a2-b32d-86ca8c240532 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80FW SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUckV SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T010739 MSH
TERMUI T010740 MSH
TERMUI T010741 MSH
TERMUI T010742 MSH
TERMUI T010743 MSH
TERMUI T527078 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH NLM (1993) MSH
TH NLM (2004) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4034^Active/Master NDFRT
VANDF_RECORD 50.6^3830^Active/Master NDFRT
VUID 4021360 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0011185

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