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Daunorubicin (CUI C0011015) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0011015

NCI Thesaurus Code: C62091  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.

NCI-GLOSS Definition: The active ingredient in a drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.

CSP Definition: anthracycline antibiotic produced by Streptomyces coeruleorubidus or Streptomyces peucetius and used as an antineoplastic.

MSH Definition: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.

Synonyms & Abbreviations: (see Synonym Details)
(+)-Daunomycin
(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,8,11-trihydroxy-6-methoxy-, (8S-cis)-
5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
Acetyladriamycin
carminomycin 11-methyl ether
Dauno Rubidomycine
Dauno-Rubidomycine
Daunomycin
Daunorrubicina
Daunorubicin (substance)
Daunorubicin [Chemical/Ingredient]
Daunorubicina
Daunorubicine
Daunorubicinum
daunorubicin
DNR
L-lyxo-Hexopyranoside, 3beta-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,alpha-
Leukaemomycin C
Product containing daunorubicin (medicinal product)
Product containing daunorubicin
Rubidomycin
RUBOMYCIN C
Rubomycin

External Source Codes: 
NCI Thesaurus Code C62091 (see NCI Thesaurus info)
CAS Registry Number 20830-81-3 (see NLM ChemIDplus info)
FDA UNII Code ZS7284E0ZP

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:41977 NCI
Chemical_Formula C27H29NO10 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID h29.. SNOMEDCT_US
CTV3ID XUVzb SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0192-2446 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
FDA_UNII_CODE ZS7284E0ZP DRUGBANK
FDA_UNII_CODE ZS7284E0ZP NDFRT
FR 0 MSH
HM D002360/Q000031 MSH
HN 80; was DAUNOMYCIN 1964-79 (Prov 1964-65) MSH
LEVEL Ingredient NDFRT
LT TRD MTH
MDA 19800101 MSH
MDA 19990101 MSH
MESH_DEFINITION A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS. NDFRT
MESH_DUI D003630 NDFRT
MESH_NAME Daunorubicin NDFRT
MESH_UI M0005683 NDFRT
MMR 20001114 MSH
MMR 20130708 MSH
MN D02.455.426.559.847.562.050.200 MSH
MN D04.615.562.050.200 MSH
MN D09.408.051.059.200 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006931 NDFRT
NUI N0000147796 NDFRT
OL use DAUNORUBICIN to search DAUNOMYCIN 1966-79 MSH
PA D000903 MSH
PA D059005 MSH
PM 80; was DAUNOMYCIN 1966-79 MSH
RN 70561-45-4 MSH
RN ZS7284E0ZP MSH
RR 20830-81-3 (Daunorubicin) MSH
RR 23541-50-6 (Daunorubicin Hydrochloride) MSH
RR 69238-09-1 (HCl(8S-cis)-isomer) MSH
RR UD984I04LZ MSH
RXAUI 2070023 RXNORM
RXAUI 3094041 RXNORM
RXAUI 3138340 RXNORM
RXAUI 3138341 RXNORM
RXAUI 3143114 RXNORM
RXAUI 3143115 RXNORM
RXAUI 3143116 RXNORM
RXAUI 3143119 RXNORM
RXAUI 3232713 RXNORM
RXAUI 3232722 RXNORM
RXAUI 3727869 RXNORM
RXAUI 6395245 RXNORM
RXAUI 92899 RXNORM
RXCUI 3109 RXNORM
SC 1 MSH
SID APRD00521 DRUGBANK
SOS RN given refers to (8S-cis)-isomer; structure MSH
SPL_SET_ID 29fe455e-f177-4b0e-99fb-60a53016db72 MTHSPL
SPL_SET_ID 4b8a5ad9-9e34-4f88-997c-244d9a0ef2c2 MTHSPL
SRC Cancer Res 40(2):387;1980 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~h29.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVzb SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T010579 MSH
TERMUI T010580 MSH
TERMUI T010581 MSH
TERMUI T010583 MSH
TERMUI T010584 MSH
TERMUI T109609 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1980) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2323^Active/Master NDFRT
VANDF_RECORD 50.6^385^Active/Master NDFRT
VUID 4019704 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0011015

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