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Creatine (CUI C0010286) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0010286

NCI Thesaurus Code: C37937  (see NCI Thesaurus info)

Semantic Type: Amino Acid, Peptide, or Protein

Semantic Type: Biologically Active Substance

NCIt Definition: An endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases.

NCI-GLOSS Definition: A substance that is made by the body and used to store energy. It is being studied in the treatment of weight loss related to cancer. It is derived from the amino acid arginine.

CSP Definition: amino acid that is synthesized in vertebrate tissues; in muscle tissue, creatine generally occurs as phosphocreatine, an important storage form of high energy phosphate; excreted as creatinine.

MSH Definition: An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.

Synonyms & Abbreviations: (see Synonym Details)
((amino(Imino)methyl)(methyl)amino)acetic acid
(alpha-Methylguanido)acetic acid
(N-methylcarbamimidamido)acetic acid
(α-methylguanido)acetic acid
alpha-Methylguanidino acetic acid
Creatine (substance)
Creatine [Chemical/Ingredient]
creatine
Creatin
Glycine, N-(aminoiminomethyl)-N-methyl-
Kreatin
Methylglycocyamine
N-(aminoiminomethyl)-N-methylglycine
N-[(e)-AMINO(imino)methyl]-N-methylglycine
N-Amidinosarcosine
N-Carbamimidoyl-N-methylglycine
N-Methyl-N-guanylglycine

External Source Codes: 
NCI Thesaurus Code C37937 (see NCI Thesaurus info)
CAS Registry Number 57-00-1 (see NLM ChemIDplus info)
FDA UNII Code MU72812GK0

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with CREATININE; CREATINE PHOSPHATE see PHOSPHOCREATINE MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHEBI_ID CHEBI:16919 NCI
Chemical_Formula C4H9N3O2 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID X80N4 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0124-2448 CSP
DX 19680101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE MU72812GK0 DRUGBANK
FDA_UNII_CODE MU72812GK0 NDFRT
HN 68; CREATINE AND CREATININE was heading 1963-67 MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine. NDFRT
MESH_DUI D003401 NDFRT
MESH_NAME Creatine NDFRT
MESH_UI M0005292 NDFRT
MMR 20130708 MSH
MN D02.078.370.280 MSH
MN D12.125.373 MSH
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000023110 NDFRT
NUI N0000170276 NDFRT
OL use CREATINE to search CREATINE AND CREATININE 1966-67 MSH
PM 68; CREATINE AND CREATININE was heading 1963-67 MSH
RN MU72812GK0 MSH
RR 57-00-1 (Creatine) MSH
RXAUI 2601930 RXNORM
RXAUI 3127793 RXNORM
RXAUI 3127794 RXNORM
RXAUI 3136150 RXNORM
RXAUI 3136172 RXNORM
RXAUI 3166321 RXNORM
RXAUI 3517251 RXNORM
RXAUI 4238232 RXNORM
RXAUI 5068036 RXNORM
RXAUI 87308 RXNORM
RXCUI 2907 RXNORM
RXN_ACTIVATED 01/28/2010 RXNORM
RXN_OBSOLETED 05/29/2009 RXNORM
SID NUTR00022 DRUGBANK
SPL_SET_ID 02e18eef-3ef1-4f02-a031-c127d0836f31 MTHSPL
SPL_SET_ID 04d84d1d-ef1f-40c2-8187-76ba6012785c MTHSPL
SPL_SET_ID 0b8bf6ae-040e-4f8f-a825-a7ae9e280c39 MTHSPL
SPL_SET_ID 29b30395-c725-23bc-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2b67a454-26ba-4049-854c-9335668236cd MTHSPL
SPL_SET_ID 2bae60bf-dda8-4710-9459-714552084fdd MTHSPL
SPL_SET_ID 386eeffc-36bd-4e24-e054-00144ff8d46c MTHSPL
SPL_SET_ID 3f145cb7-612d-4e54-b0fc-98e928bbc0b7 MTHSPL
SPL_SET_ID 4c209451-79c6-4bf3-a47b-c70bf0142375 MTHSPL
SPL_SET_ID 4c40047b-01d6-4221-a044-9f884519bdd5 MTHSPL
SPL_SET_ID 4f6a335a-c6df-4076-b6b5-371ecb03be29 MTHSPL
SPL_SET_ID 5618c08e-2e0c-4352-a3dc-ebc1e1c6e2e5 MTHSPL
SPL_SET_ID 5a9ec221-a9ec-4473-8fb0-83f10ae775e2 MTHSPL
SPL_SET_ID 5bfece38-85fa-4222-9ee3-94970afa0b9d MTHSPL
SPL_SET_ID 765b5878-bb84-4019-b104-3423ae20f238 MTHSPL
SPL_SET_ID 7a0265cb-9475-4740-9dd4-5fe2005876c9 MTHSPL
SPL_SET_ID 7e2068be-38f3-4bd9-ac08-3f572f6db2e8 MTHSPL
SPL_SET_ID 7f5b7453-e1ef-4c7f-9efa-0c0251038632 MTHSPL
SPL_SET_ID 8026db9b-5b0e-435a-bd6c-047f49aa294d MTHSPL
SPL_SET_ID 863d85d8-3996-40c3-af9f-ea84ef22bfb3 MTHSPL
SPL_SET_ID 8e8f1af0-ad54-4ec0-a809-2e682d1f89a7 MTHSPL
SPL_SET_ID 9377a5ba-f432-47df-a181-ba7a717da62b MTHSPL
SPL_SET_ID 9930ea70-a5b9-4b94-a27f-2c88279c4fbf MTHSPL
SPL_SET_ID 9f68c46b-accd-47bd-bc79-84b37f5e097d MTHSPL
SPL_SET_ID 9fa1cf9b-4b14-4fb2-8613-1273416273f4 MTHSPL
SPL_SET_ID a1860cf4-b044-4c7e-b32d-bfcecc0e67e3 MTHSPL
SPL_SET_ID a7ccbe59-16c7-42a4-8bc2-bd992d00e950 MTHSPL
SPL_SET_ID aae99e3e-0d2f-4a4f-9ffe-2349780bd5eb MTHSPL
SPL_SET_ID af05f2b7-bd7f-42a0-8042-92a0e07f0c36 MTHSPL
SPL_SET_ID b0c7bc8d-1306-4593-80e7-23f4bcdfa49d MTHSPL
SPL_SET_ID bc976541-933c-42bb-be62-b09afdabe0cd MTHSPL
SPL_SET_ID bf1d82fa-6846-4aa4-9390-c4c4e7a559dd MTHSPL
SPL_SET_ID c73ef471-8904-436f-9e98-d0d74dc25f60 MTHSPL
SPL_SET_ID cd7c35ae-7d43-4d1e-9b97-45e5c6cc5884 MTHSPL
SPL_SET_ID e5069e15-09c0-4eb1-8030-bbe65e5a4a76 MTHSPL
SPL_SET_ID f17adf17-1113-4bf1-a3e8-3513a4a3b792 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80N4 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T009893 MSH
TH FDA SRS (2014) MSH
TH NLM (1968) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4234^Active/Master NDFRT
VANDF_RECORD 50.6^4075^Active/Master NDFRT
VUID 4024927 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0010286

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