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Cortisone (CUI C0010137) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0010137

NCI Thesaurus Code: C2291  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

Semantic Type: Hormone

NCIt Definition: A steroid hormone synthesized and secreted by the adrenal gland and necessary for life. It is involved with maintaining cardiovascular function, blood glucose balance, regulating the inflammatory response and metabolism of proteins, carbohydrates, and fat.

NCI-GLOSS Definition: A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory. Cortisone reduces swelling and can suppress immune responses.

CSP Definition: naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol.

MSH Definition: A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

Synonyms & Abbreviations: (see Synonym Details)
17,21-Dihydroxypregn-4-ene-3,11,20-trione
Compound E
Cortisone (substance)
Cortisone [Chemical/Ingredient]
cortisone
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-
Product containing cortisone (medicinal product)
Product containing cortisone

External Source Codes: 
NCI Thesaurus Code C2291 (see NCI Thesaurus info)
CAS Registry Number 53-06-5 (see NLM ChemIDplus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /biosyn/physiol permitted MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:16962 NCI
CTV3ID x01Mc SNOMEDCT_US
CTV3ID XUBmb SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0059-6352 CSP
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE V27W9254FZ NDFRT
HN /adv eff-pois-tox was CORTISONE TOXICOLOGY 1963-65; /ther use was CORTISONE, THERAPEUTIC 1965 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726) NDFRT
MESH_DUI D003348 NDFRT
MESH_NAME Cortisone NDFRT
MESH_UI M0005219 NDFRT
MMR 20160528 MSH
MN D04.210.500.745.745.183 MSH
MN D06.472.040.585.478.195 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005905 NDFRT
NUI N0000146287 NDFRT
PA D000893 MSH
PM /adverse effects /poisoning /toxicity were CORTISONE TOXICOLOGY 1963-65; /therapeutic use was CORTISONE, THERAPEUTIC 1965 MSH
RN V27W9254FZ MSH
RR 53-06-5 (Cortisone) MSH
RXAUI 2069897 RXNORM
RXAUI 3127691 RXNORM
RXAUI 3127692 RXNORM
RXAUI 3135933 RXNORM
RXAUI 3135938 RXNORM
RXAUI 3223227 RXNORM
RXAUI 5950064 RXNORM
RXAUI 6395232 RXNORM
RXAUI 86322 RXNORM
RXCUI 2878 RXNORM
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SUBSET_MEMBER 900000000000497000~MAPTARGET~x01Mc SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUBmb SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
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SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T009768 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^532^Active/Master NDFRT
VANDF_RECORD 50.6^280^Active/Master NDFRT
VUID 4017937 NDFRT

Additional Concept Data:  (none)

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