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Clonazepam (CUI C0009011) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0009011

NCI Thesaurus Code: C28935  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic benzodiazepine derivative used for myotonic or atonic seizures, absence seizures, and photosensitive epilepsy, anticonvulsant Clonazepam appears to enhance gamma-aminobutyric acid receptor responses, although its mechanism of action is not clearly understood. It is seldom effective in generalized tonic-clonic or partial seizures. (NCI04)

CSP Definition: 5-(o-chlorophenyl)-1,3-dihydro -7-nitro-2H-1,4-benzodiazepin-2-one; anticonvulsant used against epileptic seizures and tardive dyskinesia.

MSH Definition: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Synonyms & Abbreviations: (see Synonym Details)
1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one
5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Clonazepam (substance)
Clonazepam [Chemical/Ingredient]
Clonazepamum
clonazepam
Product containing clonazepam (medicinal product)
Product containing clonazepam

External Source Codes: 
NCI Thesaurus Code C28935 (see NCI Thesaurus info)
CAS Registry Number 1622-61-3 (see NLM ChemIDplus info)
FDA UNII Code 5PE9FDE8GB

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3756 NCI
Chemical_Formula C15H10ClN3O3 NCI
Contributing_Source FDA NCI
CTV3ID x02Lk SNOMEDCT_US
CTV3ID XUWvT SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0314-4549 CSP
DX 19870101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 5PE9FDE8GB DRUGBANK
FDA_UNII_CODE 5PE9FDE8GB NDFRT
HN 87(75); was see under BENZODIAZEPINONES 1975-86 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741111 MSH
MESH_DEFINITION An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses. NDFRT
MESH_DUI D002998 NDFRT
MESH_NAME Clonazepam NDFRT
MESH_UI M0004601 NDFRT
MMR 20160528 MSH
MN D03.633.100.079.080.070.150 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007183 NDFRT
NUI N0000146152 NDFRT
PA D000927 MSH
PA D018757 MSH
PM 87; was see under BENZODIAZEPINONES 1975-86 MSH
RN 5PE9FDE8GB MSH
RR 1622-61-3 (Clonazepam) MSH
RXAUI 2069724 RXNORM
RXAUI 2596704 RXNORM
RXAUI 2984310 RXNORM
RXAUI 3092863 RXNORM
RXAUI 3126200 RXNORM
RXAUI 3126201 RXNORM
RXAUI 3133901 RXNORM
RXAUI 3133902 RXNORM
RXAUI 3608299 RXNORM
RXAUI 3726079 RXNORM
RXAUI 78301 RXNORM
RXCUI 2598 RXNORM
SID APRD00054 DRUGBANK
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SPL_SET_ID ff316953-15c5-434d-abbf-7b675492e2cc MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02Lk SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWvT SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T008695 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USAN (1969) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^386^Active/Master NDFRT
VANDF_RECORD 50.6^161^Active/Master NDFRT
VUID 4017791 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0009011

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