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Choline (CUI C0008405) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0008405

NCI Thesaurus Code: C61674  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Biologically Active Substance

Semantic Type: Pharmacologic Substance

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Choline helps cells make membranes, make a neurotransmitter (a chemical that helps nerve cells communicate with other cells), and remove fat from the liver. It is found in whole milk, beef liver, eggs, soy foods, and peanuts. Choline is water-soluble (can dissolve in water) and must be taken in every day. Not enough choline can cause diseases of the heart and blood vessels and damage to the liver. A form of choline is being studied in the treatment of some types of cancer and to reduce pain and fever. Choline is also being studied together with vitamin B12 in the prevention and treatment of cancer.

CRCH Definition: Water-soluble vitamin that is a precursor for acetylcholine, phospholipids, and the methyl donor betaine. (DRI)

CSP Definition: essential nutrient that is part of the B-complex family of vitamins and is a constituent of lecithin; it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism; it also aids in hormone production and is needed for the proper transmission of nerve impulses, liver function and gallbladder regulation.

MSH Definition: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Synonyms & Abbreviations: (see Synonym Details)
(2-Hydroxyethyl)trimethylammonium
2-Hydroxy-N,N,N-trimethylethanaminium
2-hydroxyethyl-trimethyl-ammonium
Choline (substance)
Choline [Chemical/Ingredient]
choline
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-
N,N,N-trimethylethanol-ammonium
N-trimethylethanolamine
Product containing choline (medicinal product)
Product containing choline
trimethylethanolamine
Vitamin J

External Source Codes: 
NCI Thesaurus Code C61674 (see NCI Thesaurus info)
CAS Registry Number 62-49-7 (see NLM ChemIDplus info)
FDA UNII Code N91BDP6H0X

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN /biosyn /physiol permitted MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:15354 NCI
Chemical_Formula C5H14NO NCI
Contributing_Source CRCH NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID Ub08Y SNOMEDCT_US
CTV3ID XU2pX SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0663-0420 CSP
DX 19660101 MSH
EC deficiency:Choline Deficiency MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE N91BDP6H0X DRUGBANK
FDA_UNII_CODE N91BDP6H0X NDFRT
INFOODS CHOLN NCI
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. NDFRT
MESH_DUI D002794 NDFRT
MESH_NAME Choline NDFRT
MESH_UI M0004283 NDFRT
Micronutrient Y NCI
MMR 20160520 MSH
MN D02.033.100.291.211 MSH
MN D02.092.063.291.211 MSH
MN D02.092.877.883.333 MSH
MN D02.675.276.232 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007087 NDFRT
NUI N0000146071 NDFRT
Nutrient Y NCI
PA D008082 MSH
PA D018697 MSH
RN N91BDP6H0X MSH
RR 45I14D8O27 MSH
RR 62-49-7 (Choline) MSH
RR 67-48-1 (Cl) MSH
RR 6K2W7T9V6Y MSH
RR 7THJ3EG9SY MSH
RXAUI 2069630 RXNORM
RXAUI 3092531 RXNORM
RXAUI 3124598 RXNORM
RXAUI 3124599 RXNORM
RXAUI 3132933 RXNORM
RXAUI 3132962 RXNORM
RXAUI 3155744 RXNORM
RXAUI 3612826 RXNORM
RXAUI 5462441 RXNORM
RXAUI 6396151 RXNORM
RXAUI 74992 RXNORM
RXCUI 2449 RXNORM
SID NUTR00020 DRUGBANK
SPL_SET_ID 0ae761bf-8a32-4ca2-a554-e2402e8a4163 MTHSPL
SPL_SET_ID 188b8a95-3db7-4a6a-bddf-48b83a0c8e38 MTHSPL
SPL_SET_ID 1c55c61a-2692-4cd2-943b-78bbf03fd914 MTHSPL
SPL_SET_ID 253ea822-c2e3-688b-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2981c1b7-2584-496a-a77e-8ea0594d5065 MTHSPL
SPL_SET_ID 2c9328e1-07d9-4f8c-8912-04fb2bf16a7b MTHSPL
SPL_SET_ID 2dd25bf2-f1a7-4bc4-bdf2-12d9065ea0cf MTHSPL
SPL_SET_ID 2e63e2be-810b-426c-a15d-80659317be21 MTHSPL
SPL_SET_ID 30d7c66e-9a92-4e96-9ec9-20bbdd863a2a MTHSPL
SPL_SET_ID 3364cee6-0a88-47bb-9af8-8e90843de236 MTHSPL
SPL_SET_ID 34d3382c-8ccd-4d1c-805d-223b4ca05d04 MTHSPL
SPL_SET_ID 34e283a5-ac21-4899-9524-ff5aaddbb436 MTHSPL
SPL_SET_ID 35fee753-acd7-4da2-bd60-973dc6c0b21f MTHSPL
SPL_SET_ID 39d936d1-29a7-48b6-9327-94f2028012e7 MTHSPL
SPL_SET_ID 3f06ba26-26aa-4748-82dc-5748ed6717ea MTHSPL
SPL_SET_ID 458264ac-411a-4f2f-8393-7a5cb8459f27 MTHSPL
SPL_SET_ID 4c9bbe4f-44ae-4f99-8371-a607d81cc8cd MTHSPL
SPL_SET_ID 52057058-abdb-44ed-b60d-a718c97fbfda MTHSPL
SPL_SET_ID 54101870-d8a8-4b35-a31d-93480af9d181 MTHSPL
SPL_SET_ID 61945c85-3c9a-4b57-a8e1-79dd0469a042 MTHSPL
SPL_SET_ID 6224f2c5-8e3c-4bcf-a8c6-a97004d6f432 MTHSPL
SPL_SET_ID 62b89b45-1d1f-45e3-83b8-77d55b590ff9 MTHSPL
SPL_SET_ID 64b358e5-6cad-40bc-bc53-5a4074ee92ef MTHSPL
SPL_SET_ID 64d403dc-90ca-414d-8ffb-f01a611e66c0 MTHSPL
SPL_SET_ID 68b9c2df-971d-46ea-94d6-f0a868b7c5a0 MTHSPL
SPL_SET_ID 692849e3-6679-f337-e8d2-2be584767802 MTHSPL
SPL_SET_ID 7c76bce0-5f91-4c32-a1d9-b2cd607418c2 MTHSPL
SPL_SET_ID 83df297b-6467-451e-af4d-2c1f996cd009 MTHSPL
SPL_SET_ID 8435a842-56dd-41d9-be94-2817f83a42cb MTHSPL
SPL_SET_ID 98a7ca26-ccb7-43c7-bd65-892fcbacc882 MTHSPL
SPL_SET_ID a4231f67-6c04-4ce6-8c3d-6db52afaadbe MTHSPL
SPL_SET_ID a59088ed-17b2-430e-9f49-022ce0afd531 MTHSPL
SPL_SET_ID b0e39608-a7ed-464a-91c9-867ad7cd293c MTHSPL
SPL_SET_ID b8b84aaf-83d2-4d77-bb72-83dd26173f76 MTHSPL
SPL_SET_ID b9974633-f293-4dd0-a3c6-769c154bd082 MTHSPL
SPL_SET_ID bc787147-a6b6-4041-874f-cd7f5601bd6f MTHSPL
SPL_SET_ID c4b5257a-4dfa-4a58-a05b-c0a32dbb9352 MTHSPL
SPL_SET_ID c54d391e-33d1-4af8-a510-321a544c50c4 MTHSPL
SPL_SET_ID ca3c681c-5e5b-34d0-5917-549529afa65d MTHSPL
SPL_SET_ID d267425d-4e5f-4e7a-a27e-fe8814f0e225 MTHSPL
SPL_SET_ID d31076b4-44ac-4f8b-8df6-5200cdbea12b MTHSPL
SPL_SET_ID d5f0457f-b722-48b7-8901-61da7fbb4090 MTHSPL
SPL_SET_ID e03becf9-dd73-48fc-9faa-90d8243c725b MTHSPL
SPL_SET_ID ed303817-d606-4554-ac71-ac9b8012090b MTHSPL
SPL_SET_ID f0a096a0-bde2-494f-a1af-2f778bb7c5c1 MTHSPL
SPL_SET_ID f72a1419-0df4-4aaa-84cf-606a17cac493 MTHSPL
SPL_SET_ID f7445e81-8ae7-47fb-81c0-6b14837edbe4 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~Ub08Y SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU2pX SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T008129 MSH
TERMUI T008130 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH NLM (1996) MSH
Tolerable_Level Y NCI
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit mcg NCI
US_Recommended_Intake Y NCI
USDA_ID 421 NCI
VANDF_RECORD 50.416^294^Active/Master NDFRT
VANDF_RECORD 50.6^3020^Active/Master NDFRT
VUID 4017699 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0008405

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