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Cholesteatoma (CUI C0008373) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0008373

NCI Thesaurus Code: C2944  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A pathologic process characterized by the proliferation of keratinizing squamous epithelium resulting in the accumulation of keratin and cells in the middle ear and/or mastoid. It may be congenital or acquired. If left untreated, it may increase in size and destroy adjacent structures.

RADLEX Definition: an accumulation of desquamated keratin epithelium in the middle ear cleft or any other pneumatized portion of the temporal bone

GARD Definition: Cholesteatoma is a type of skin cyst located in the middle ear. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. The hallmark symptom is a painless discharge from the ear. Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth.  Surgery can stop infections and prevent complications.   
- this information is from GARD/ORDR/NCATS.

HPO Definition: Cholesteatoma is a benign but potentially destructive growth consisting of keratinizing epithelium located in the middle ear and/or mastoid process. In cholesteatoma, a skin cyst grows into the middle ear and mastoid. The cyst is not cancerous but can erode tissue and cause destruction of the ear. [HPO:curators]

CSP Definition: non-neoplastic keratinizing mass with stratified squamous epithelium, frequently occurring in the meninges, central nervous system, bones of the skull, and most commonly in the middle ear and mastoid region.

MSH Definition: A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.

Synonyms & Abbreviations: (see Synonym Details)
Cholesteatoma (disorder)
Cholesteatoma (morphologic abnormality)
Cholesteatoma [Disease/Finding]
Cholesteatoma NOS
Cholesteatoma, unspecified
Cholesteatomas
cholesteatoma
Cholesteatom
Epidermoid cholesteatoma
Unspecified cholesteatoma, unspecified ear
Unspecified cholesteatoma

External Source Codes: 
NCI Thesaurus Code C2944 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate IM with organ/disease (IM) but CHOLESTEATOMA, MIDDLE EAR is available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID X00j3 SNOMEDCT_US
CTV3ID XUTmz SNOMEDCT_US
DATE_CREATED 2009-02-11T05:20:04Z HPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2000-3571 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
HAS_GARD_PAGE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-01-27T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL. NDFRT
MESH_DUI D002781 NDFRT
MESH_NAME Cholesteatoma NDFRT
MESH_UI M0004265 NDFRT
MMR 20130709 MSH
MN C17.800.428.260 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000000764 NDFRT
ORDER_NO 10241 ICD10CM
ORDER_NO 10242 ICD10CM
PRIMARY_PATH 10008642$10003792$10027656$10029104$Cholesteatoma$Aural neoplasms benign$Miscellaneous and site unspecified neoplasms benign$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10422/cholesteatoma/resources/1 GARD
RXAUI 3132841 RXNORM
RXAUI 3132842 RXNORM
RXCUI 1024293 RXNORM
SNOMED_CID 363668000 NDFRT
SNOMEDID DA-90006 SNOMEDCT_US
SNOMEDID M-72900 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS H71 | MAPPED FOLLOWING WHO GUIDANCE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~H71 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS H71.90 | CONSIDER LATERALITY SPECIFICATION | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H71.90 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X00j3 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUTmz SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-90006 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-72900 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T008075 MSH
TH NLM (1966) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0008373

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