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Chloroquine (CUI C0008269) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0008269

NCI Thesaurus Code: C61671  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

PDQ Definition: A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Check for active clinical trials using this agent. (NCI Thesaurus)

CSP Definition: antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus.

MSH Definition: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.

Synonyms & Abbreviations: (see Synonym Details)
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
54-05-7
Chingamin
Chloraquine
Chlorochine
Chlorochin
Chloroquina
Chloroquine (substance)
Chloroquine [Chemical/Ingredient]
chloroquine
Chloroquinium
Chloroquinum
Cloroquina
Khingamin
N(4)-(7-chloro-4-Quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
Product containing chloroquine (medicinal product)
Product containing chloroquine

External Source Codes: 
NCI Thesaurus Code C61671 (see NCI Thesaurus info)
CAS Registry Number 54-05-7 (see NLM ChemIDplus info)
FDA UNII Code 886U3H6UFF
PDQ Closed Trial Search ID 654729
PDQ Open Trial Search ID 654729 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3638 NCI
Chemical_Formula C18H26ClN3 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID x02M2 SNOMEDCT_US
CTV3ID XUWIy SNOMEDCT_US
DATE_FIRST_PUBLISHED 2009-09-10 PDQ
DATE_LAST_MODIFIED 2009-09-10 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2530-4570 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 886U3H6UFF DRUGBANK
FDA_UNII_CODE 886U3H6UFF NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. NDFRT
MESH_DUI D002738 NDFRT
MESH_NAME Chloroquine NDFRT
MESH_UI M0004182 NDFRT
MMR 20160528 MSH
MN D03.633.100.810.050.180 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C61671 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007737 NDFRT
NUI N0000147767 NDFRT
ORIG_STY Drug/agent PDQ
PA D000563 MSH
PA D000962 MSH
PA D018501 MSH
RN 886U3H6UFF MSH
RR 54-05-7 (Chloroquine) MSH
RR OE48649K6N MSH
RXAUI 2069565 RXNORM
RXAUI 3091257 RXNORM
RXAUI 3123922 RXNORM
RXAUI 3123923 RXNORM
RXAUI 3132398 RXNORM
RXAUI 3132573 RXNORM
RXAUI 3132645 RXNORM
RXAUI 3132646 RXNORM
RXAUI 3184576 RXNORM
RXAUI 6395143 RXNORM
RXAUI 73108 RXNORM
RXCUI 2393 RXNORM
SID APRD00468 DRUGBANK
SPL_SET_ID 04e873d3-bc40-4f6c-bc7e-7658a23cdba1 MTHSPL
SPL_SET_ID 06c69e2b-211b-4746-9f3a-f86d36520570 MTHSPL
SPL_SET_ID 2add8326-3248-4e6c-8a07-495245c1a21c MTHSPL
SPL_SET_ID 45caa78b-11ca-4230-9e57-5cca759af239 MTHSPL
SPL_SET_ID 56f3380c-9411-417a-a3f7-fe4025900c75 MTHSPL
SPL_SET_ID 638e62df-5bbc-41c3-aa88-eb36781c2af6 MTHSPL
SPL_SET_ID 9b585ad5-ae86-4403-b83f-8d8363d43da5 MTHSPL
SPL_SET_ID abebf252-4ee0-46fb-a969-5ef0a4da414b MTHSPL
SPL_SET_ID bd995175-2298-4e3e-94e9-4f723c353a18 MTHSPL
SPL_SET_ID cb4f4415-a614-476a-b897-a14842e69bd8 MTHSPL
SPL_SET_ID eb02c52d-907c-43fb-aa8f-2f378a9087e7 MTHSPL
SPL_SET_ID ee944d28-f596-4163-a502-e779c0d622bc MTHSPL
SPL_SET_ID f398f8a9-92f3-47cb-81c2-6078806a464d MTHSPL
SPL_SET_ID fa6cfb92-c856-41a1-b846-40e650ecfa80 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02M2 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWIy SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007934 MSH
TERMUI T007935 MSH
TERMUI T007936 MSH
TERMUI T007937 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2294^Active/Master NDFRT
VANDF_RECORD 50.6^529^Active/Master NDFRT
VUID 4019675 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0008269

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