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Chloroform (CUI C0008238) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0008238

NCI Thesaurus Code: C29815  (see NCI Thesaurus info)

Semantic Type: Indicator, Reagent, or Diagnostic Aid

Semantic Type: Hazardous or Poisonous Substance

Semantic Type: Organic Chemical

NCIt Definition: A colorless, volatile, liquid derivative of trichloromethane with an ether-like odor. Formerly used as an inhaled anesthetic during surgery, the primary use of chloroform today is in industry, where it is used as a solvent and in the production of the refrigerant freon. Acute chloroform toxicity results in impaired liver function, cardiac arrhythmia, nausea and central nervous system dysfunction. As a byproduct of water chlorination, chloroform may be present in small amounts in chlorinated water. (NCI04)

CSP Definition: commonly used laboratory solvent formerly used as an anesthetic, possible carcinogen.

MSH Definition: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

Synonyms & Abbreviations: (see Synonym Details)
Chloroform (product)
Chloroform (substance)
Chloroform [Chemical/Ingredient]
chloroform
Methane, trichloro-
trichloromethane

External Source Codes: 
NCI Thesaurus Code C29815 (see NCI Thesaurus info)
CAS Registry Number 67-66-3 (see NLM ChemIDplus info)
FDA UNII Code 7V31YC746X
NSC Code 77361 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:35255 NCI
Chemical_Formula CHCl3 NCI
Contributing_Source FDA NCI
CTV3ID X809Z SNOMEDCT_US
CTV3ID XUebc SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1371-7086 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20070131 SNOMEDCT_US
FDA_UNII_CODE 7V31YC746X NDFRT
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity. NDFRT
MESH_DUI D002725 NDFRT
MESH_NAME Chloroform NDFRT
MESH_UI M0004164 NDFRT
MMR 20130708 MSH
MN D02.455.526.439.224 MSH
MN D02.455.526.913.810 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000166326 NDFRT
NUI N0000171757 NDFRT
PA D012997 MSH
RN 7V31YC746X MSH
RR 67-66-3 (Chloroform) MSH
RXAUI 2601876 RXNORM
RXAUI 3123870 RXNORM
RXAUI 3123871 RXNORM
RXAUI 3132586 RXNORM
RXAUI 3132587 RXNORM
RXAUI 3198219 RXNORM
RXAUI 3250609 RXNORM
RXAUI 4660668 RXNORM
RXAUI 5040275 RXNORM
RXCUI 1362698 RXNORM
SOS A vaporous anesthetic depressant similar to ether that is capable of producing an alcohol-like intoxication when inhaled. Never very popular, chloroform is known to be more frequently fatal than any of the other anesthetics or alcohol. It also is used as a solvent. AOD
SOS Classification: volatile inhalants. AOD
SPL_SET_ID 22de9aa2-83f1-4453-9d14-13af3e3aee9f MTHSPL
SPL_SET_ID 4c130208-8e8a-46aa-bd2a-6ddc6afbb8ac MTHSPL
SPL_SET_ID 4d705c57-fa98-46e0-97f3-38e1b0ada76b MTHSPL
SPL_SET_ID 82f19223-c3ca-46b8-8c97-30f9ae702888 MTHSPL
SPL_SET_ID 8e5dab9c-755b-460e-afe2-1ddfc4acfd96 MTHSPL
SPL_SET_ID e764aecd-def2-4c7b-aeb5-6709be365863 MTHSPL
SPL_SET_ID f6fdc88b-ea00-4694-8f21-b8d15dbb339e MTHSPL
SPL_SET_ID fc36eaa5-499d-4a96-a144-cffae64878a4 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X809Z SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUebc SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T007901 MSH
TERMUI T007902 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4279^Active/Master NDFRT
VUID 4025221 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0008238

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