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Chlordiazepoxide (CUI C0008188) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0008188

NCI Thesaurus Code: C47443  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A long-acting benzodiazepine with anxiolytic, sedative and hypnotic activity. Chlordiazepoxide exerts its effect by binding to the benzodiazepine site at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA on the CNS.

CSP Definition: anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties; also used in the symptomatic treatment of alcohol withdrawal.

MSH Definition: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

Synonyms & Abbreviations: (see Synonym Details)
3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide
3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide
7 Chloro N methyl 5 phenyl 3H 1,4 benzodiazepin 2 amine 4 oxide
7-chloro-2-Methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide
7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide
7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
CDP
Chloradiazepoxide
Chlordiazepoxide (substance)
Chlordiazepoxide [Chemical/Ingredient]
Chlordiazepoxide base
chlordiazepoxide
Chlordiazepoxidum
Librelease
Libritabs
methaminodiazepoxide
Product containing chlordiazepoxide (medicinal product)
Product containing chlordiazepoxide

External Source Codes: 
NCI Thesaurus Code C47443 (see NCI Thesaurus info)
CAS Registry Number 58-25-3 (see NLM ChemIDplus info)
FDA UNII Code 6RZ6XEZ3CR

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3611 NCI
Chemical_Formula C16H14ClN3O NCI
Contributing_Source FDA NCI
CTV3ID d24.. SNOMEDCT_US
CTV3ID XUW24 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0314-4236 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
FDA_UNII_CODE 6RZ6XEZ3CR DRUGBANK
FDA_UNII_CODE 6RZ6XEZ3CR NDFRT
FR 0 MSH
HM D001569 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MTH
MDA 19990101 MSH
MDA 20140130 MSH
MESH_DEFINITION An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. NDFRT
MESH_DUI D002707 NDFRT
MESH_NAME Chlordiazepoxide NDFRT
MESH_UI M0004133 NDFRT
MMR 20160528 MSH
MN D03.633.100.079.080.150 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006824 NDFRT
NUI N0000146141 NDFRT
PA D000759 MSH
PA D006993 MSH
PA D014151 MSH
PA D018757 MSH
RN 0 MSH
RN 6RZ6XEZ3CR MSH
RR 121531-47-3 (mono-HClO4) MSH
RR 14844-23-6 (HCl) MSH
RR 438-41-5 (mono-HCl) MSH
RR 56617-98-2 (HBr) MSH
RR 58-25-3 (Chlordiazepoxide) MSH
RR MFM6K1XWDK MSH
RXAUI 1179822 RXNORM
RXAUI 2069542 RXNORM
RXAUI 3086312 RXNORM
RXAUI 3093367 RXNORM
RXAUI 3094541 RXNORM
RXAUI 3123725 RXNORM
RXAUI 3123726 RXNORM
RXAUI 3132458 RXNORM
RXAUI 3132462 RXNORM
RXAUI 3198191 RXNORM
RXAUI 3727864 RXNORM
RXAUI 6395203 RXNORM
RXAUI 6396146 RXNORM
RXAUI 72318 RXNORM
RXCUI 218007 RXNORM
RXCUI 2356 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SC 1 MSH
SID APRD00682 DRUGBANK
SOS An antianxiety tranquilizer derived from benzodiazepine. AOD
SOS structure in first source MSH
SPL_SET_ID 0462b7b2-efe4-439b-8322-f8f07fcd6b8c MTHSPL
SPL_SET_ID 07f01b74-2914-4c9c-98d0-1e5ba52cc628 MTHSPL
SPL_SET_ID 087ac5c5-ff14-1cf3-85b7-9f0d80286e76 MTHSPL
SPL_SET_ID 0f2c7899-8cbb-467f-973b-484197c31c23 MTHSPL
SPL_SET_ID 171404f0-d87a-4fc5-9551-e5139cf80988 MTHSPL
SPL_SET_ID 1865ed7b-1e9f-41f2-8a42-12dee02e4fc4 MTHSPL
SPL_SET_ID 22d710ec-302a-4756-95e3-8ee7957586e4 MTHSPL
SPL_SET_ID 25e0c1fd-fa65-4868-b425-c5d7c3439cff MTHSPL
SPL_SET_ID 275bd9da-c7f6-4d5f-853f-c0b06494947d MTHSPL
SPL_SET_ID 2f1d49ad-13cb-2a23-e054-00144ff88e88 MTHSPL
SPL_SET_ID 3cbd7cee-c4d7-4c95-93d8-09428169b937 MTHSPL
SPL_SET_ID 42b4b9c2-24d7-439b-a90a-f1fcba0a1948 MTHSPL
SPL_SET_ID 66a756f2-ac77-451c-a19a-08896d73b15c MTHSPL
SPL_SET_ID 68c7d8a7-08b3-4a1a-acbd-09bbe67b8d4a MTHSPL
SPL_SET_ID 69e56e41-8413-4439-8cc0-caf17d60526d MTHSPL
SPL_SET_ID 720bb488-30df-4eca-8b5d-87b73272a509 MTHSPL
SPL_SET_ID 82af38e7-33d7-4c68-8fa8-c753762bd60e MTHSPL
SPL_SET_ID 8477a865-8f88-44f9-9ac6-4f99526cf8bb MTHSPL
SPL_SET_ID 8613764c-5c70-43cb-bad6-3859d1095eb1 MTHSPL
SPL_SET_ID 93718b2e-ac37-4521-a3c8-0a246d3e4561 MTHSPL
SPL_SET_ID 98a991b9-2af3-4055-a16e-f784c7dbbb8a MTHSPL
SPL_SET_ID a67a054d-504b-0b75-ae93-560d4948cc6d MTHSPL
SPL_SET_ID a6a63bd7-adcb-4909-84b4-30c0dc1d76f2 MTHSPL
SPL_SET_ID A96B7385-8EE1-4B23-AA15-AA4AFD4C40B4 MTHSPL
SPL_SET_ID b11a0582-eb80-4d60-914e-dc8e84177869 MTHSPL
SPL_SET_ID b1bd1c1a-0b80-4ef0-94e1-c00cc3010601 MTHSPL
SPL_SET_ID b2e9c10e-3e61-4f3a-aebe-5cdb9274a8ad MTHSPL
SPL_SET_ID bf602097-9017-4bdf-9232-454829001121 MTHSPL
SPL_SET_ID d7b991cb-6f23-47d8-8e7c-2f9b7b4c6261 MTHSPL
SPL_SET_ID d8dd70f1-b9b3-4a6a-be09-73913d1a7e51 MTHSPL
SPL_SET_ID e167e7a4-786c-4373-8c24-ee0618beb020 MTHSPL
SPL_SET_ID e3ff8641-ae8a-4016-acb1-cb1b7890f5ed MTHSPL
SPL_SET_ID e8e41a74-6816-4b9a-9905-d072e6e4cfa8 MTHSPL
SPL_SET_ID eb0798ae-f54e-4f9d-8a2e-41bfd176caa5 MTHSPL
SPL_SET_ID eb0fd4f8-adf8-436d-b0d3-c28f36228311 MTHSPL
SPL_SET_ID f99ebf66-f207-4a97-9666-4da1d72b061c MTHSPL
SPL_SET_ID f9aad3ba-f17f-45de-8a12-6cef592170c6 MTHSPL
SPL_SET_ID fdf7d0c2-82bd-49b9-aceb-2fb0bff355b9 MTHSPL
SPL_SET_ID ff20f35c-b8e3-487a-a15e-f194a659c612 MTHSPL
SRC Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;113():224-35 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~d24.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUW24 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007842 MSH
TERMUI T007843 MSH
TERMUI T007844 MSH
TERMUI T854362 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1995) MSH
TH NLM (2014) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^375^Active/Master NDFRT
VANDF_RECORD 50.6^176^Active/Master NDFRT
VUID 4017780 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0008188

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