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Cephalothin (CUI C0007735) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007735

NCI Thesaurus Code: C62021  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

MSH Definition: A cephalosporin antibiotic.

Synonyms & Abbreviations: (see Synonym Details)
3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-8-oxo-7-((2-thienylacetyl)amino)-, (6R-trans)-
7-(2'-Thienylacetamido)cephalosporanic acid
7-(2-Thienylacetamido)cephalosporanic acid
7-(Thiophene-2-acetamido)cephalosporin
Cefalothin
Cefalotin (substance)
Cefalotina
Cefalotine
Cefalotinum
Cefalotin
Cephalothin [Chemical/Ingredient]
cephalothin
Cephalotin
CET
Product containing cefalotin (medicinal product)
Product containing cefalotin
Product containing cephalothin

External Source Codes: 
NCI Thesaurus Code C62021 (see NCI Thesaurus info)
CAS Registry Number 153-61-7 (see NLM ChemIDplus info)
FDA UNII Code R72LW146E6

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:124991 NCI
Chemical_Formula C16H16N2O6S2 NCI
Contributing_Source FDA NCI
CTV3ID e6a.. SNOMEDCT_US
CTV3ID XUWJF SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0199-6901 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE R72LW146E6 DRUGBANK
FDA_UNII_CODE R72LW146E6 NDFRT
HN 66(63) MSH
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A cephalosporin antibiotic. NDFRT
MESH_DUI D002512 NDFRT
MESH_NAME Cephalothin NDFRT
MESH_UI M0003828 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.190.210 MSH
MN D02.886.665.074.190.210 MSH
MN D03.633.100.300.249.190.210 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006733 NDFRT
NUI N0000147761 NDFRT
PA D000900 MSH
PM 66 MSH
RN R72LW146E6 MSH
RR 153-61-7 (Cephalothin) MSH
RR 58-71-9 (mono-Na salt) MSH
RR C22G6EYP8B MSH
RXAUI 2069480 RXNORM
RXAUI 3094240 RXNORM
RXAUI 3123149 RXNORM
RXAUI 3123150 RXNORM
RXAUI 3131094 RXNORM
RXAUI 3131558 RXNORM
RXAUI 3131560 RXNORM
RXAUI 68439 RXNORM
RXCUI 2236 RXNORM
SID APRD00859 DRUGBANK
SID EXPT00946 DRUGBANK
SUBSET_MEMBER 900000000000497000~MAPTARGET~e6a.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWJF SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007320 MSH
TERMUI T007321 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2288^Active/Master NDFRT
VANDF_RECORD 50.6^74^Active/Master NDFRT
VUID 4019669 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007735

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