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Celiac Disease (CUI C0007570) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007570

NCI Thesaurus Code: C26714  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

RADLEX Definition: a digestive disease that damages the small intestine and interferes with absorption of nutrients from food. People who have celiac disease cannot tolerate a protein called gluten, found in wheat, rye, and barley. When people with celiac disease eat foods or use products containing gluten, their immune system responds by damaging the small intestine.

GARD Definition: Celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. People with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. When affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. Because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. Classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. However, many people have other symptoms involving many body systems, and some people have no symptoms. While celiac disease tends to run in families, it does not follow a specific inheritance pattern. The risk to develop celiac disease is raised by having certain forms of the HLA-DQA1 and HLA-DQB1 genes. Treatment is a lifelong, gluten-free diet. - this information is from GARD/ORDR/NCATS.

HPO Definition: Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases. [HPO:probinson, pmid:23681421]

MEDLINEPLUS Definition: 

Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley. It is found mainly in foods but may also be in other products like medicines, vitamins and supplements, lip balm, and even the glue on stamps and envelopes.

Celiac disease affects each person differently. Symptoms may occur in the digestive system, or in other parts of the body. One person might have diarrhea and abdominal pain, while another person may be irritable or depressed. Irritability is one of the most common symptoms in children. Some people have no symptoms.

Celiac disease is genetic. Blood tests can help your doctor diagnose the disease. Your doctor may also need to examine a small piece of tissue from your small intestine. Treatment is a diet free of gluten.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

HPO Definition: A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease. [HPO:probinson]

NCI-GLOSS Definition: A digestive disease that is caused by an immune response to a protein called gluten, which is found in wheat, rye, barley, and oats. Celiac disease damages the lining of the small intestine and interferes with the absorption of nutrients from food. A person with celiac disease may become malnourished no matter how much food is consumed.

CSP Definition: disease occurring in children and adults characterized by sensitivity to gluten, with chronic inflammation and atrophy of the mucosa of the upper small intestine; manifestations include diarrhea, malabsorption, steatorrhea, and nutritional and vitamin deficiencies.

MSH Definition: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

Synonyms & Abbreviations: (see Synonym Details)
CD - Celiac disease
CD - Coeliac disease
Celiac disease (disorder)
Celiac Disease [Disease/Finding]
celiac disease
CELIAC DIS
celiac sprue
Celiac syndrome
Coeliac disease
Coeliac sprue
Coeliac syndrome
CS - Celiac sprue
CS - Coeliac sprue
Disease, Celiac
Enteropathies, Gluten-Sensitive
Enteropathies, Gluten
Enteropathy, Gluten-Sensitive
Enteropathy, Gluten
Gluten Enteropathies
gluten enteropathy
GLUTEN INTOLERANCE
Gluten sensitive enteropathy
Gluten-induced enteropathy syndrome
Gluten-induced enteropathy
Gluten-responsive sprue
Gluten-Sensitive Enteropathies
Gluten-sensitive enteropathy
GSE - Gluten-sensitive enteropathy
idiopathic steatorrhea
Idiopathic steatorrhoea
Non Tropical Sprue
Non-tropical sprue
NONTROPICAL SPRUE
Sprue, Celiac
Sprue, Nontropical
Sprue
Wheat-sensitive enteropathy

External Source Codes: 
NCI Thesaurus Code C26714 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with SPRUE, TROPICAL MSH
ANSWER_CODE 2 LNC
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CODE_ALSO exocrine pancreatic insufficiency (K86.81) ICD10CM
CTV3ID XUY1m SNOMEDCT_US
DATE_CREATED 11/10/1999 MEDLINEPLUS
DATE_CREATED 2013-12-15T10:31:34Z HPO
DATE_CREATED 2014-01-03T00:02:00 GARD
DATE_LAST_MODIFIED 2014-01-03T00:02:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1248-3893 CSP
DISEASE_IDENTIFIER_ID 23117 GARD
DISEASE_IDENTIFIER_ID 23118 GARD
DISEASE_IDENTIFIER_ID 23119 GARD
DISEASE_IDENTIFIER_ID 23120 GARD
DISEASE_IDENTIFIER_ID 23121 GARD
DISEASE_IDENTIFIER_ID 23122 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20030731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FX D013182 MSH
FX D021182 MSH
FX D058527 MSH
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
ICE Celiac: {crisis; infantilism; rickets}; Gee (-Herter) disease; Gluten enteropathy; Idiopathic steatorrhea; Nontropical sprue ICD9CM
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Gluten-sensitive enteropathy ICD10
INCLUSION_TERM Idiopathic steatorrhoea ICD10
INCLUSION_TERM Nontropical sprue ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
MDA 19990101 MSH
MESH_DEFINITION A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. NDFRT
MESH_DUI D002446 NDFRT
MESH_NAME Celiac Disease NDFRT
MESH_UI M0003736 NDFRT
MMR 20130708 MSH
MN C06.405.469.637.250 MSH
MN C18.452.603.250 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/celiacdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/celiacdisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
MSC Diagnosis.Term MTHMST
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000000704 NDFRT
ORDER_NO 13714 ICD10CM
PRIMARY_PATH 10009839$10025480$10025477$10017947$Coeliac disease$Malabsorption syndromes$Malabsorption conditions$Gastrointestinal disorders MDR
PRIMARY_SOC 10017947 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/11998/celiac-disease/resources/1 GARD
RXAUI 3131173 RXNORM
RXAUI 3131174 RXNORM
RXAUI 3166150 RXNORM
RXAUI 3166154 RXNORM
RXAUI 3240013 RXNORM
RXAUI 3240014 RXNORM
RXAUI 5039059 RXNORM
RXAUI 5932306 RXNORM
RXCUI 1022566 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 396331005 NDFRT
SNOMEDID D5-40078 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS K90.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~K90.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS K90.0 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF CELIAC DISEASE WITH DIFFUSE INTESTINAL ULCERATION CHOOSE K63.3 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 61715008 | Celiac disease with diffuse intestinal ulceration (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K63.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K90.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUY1m SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D5-40078 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007139 MSH
TERMUI T007140 MSH
TERMUI T539617 MSH
TERMUI T539618 MSH
TERMUI T539619 MSH
TERMUI T811444 MSH
TERMUI T841090 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH NLM (2004) MSH
TH NLM (2014) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code for associated disorders including: ICD10CM
USE_ADDITIONAL dermatitis herpetiformis (L13.0) ICD10CM
USE_ADDITIONAL gluten ataxia (G32.81) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007570

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