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Cefuroxime (CUI C0007562) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007562

NCI Thesaurus Code: C61669  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

MSH Definition: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-3-[(Carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-
Cefuroxime (substance)
Cefuroxime [Chemical/Ingredient]
Cefuroxime
Cefuroximo
Cefuroximum
Cefuroxim
Cephuroxime
Product containing cefuroxime (medicinal product)
Product containing cefuroxime

External Source Codes: 
NCI Thesaurus Code C61669 (see NCI Thesaurus info)
CAS Registry Number 55268-75-2 (see NLM ChemIDplus info)
FDA UNII Code O1R9FJ93ED

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3515 NCI
Chemical_Formula C16H16N4O8S NCI
Contributing_Source FDA NCI
CTV3ID e68.. SNOMEDCT_US
CTV3ID XUW1X SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19910101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE O1R9FJ93ED DRUGBANK
FDA_UNII_CODE O1R9FJ93ED NDFRT
HN 91(80); was see under CEPHALOSPORINS 1980-90 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19790301 MSH
MESH_DEFINITION Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS. NDFRT
MESH_DUI D002444 NDFRT
MESH_NAME Cefuroxime NDFRT
MESH_UI M0003733 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.190.190.165 MSH
MN D02.886.665.074.190.190.165 MSH
MN D03.633.100.300.249.190.190.165 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007881 NDFRT
NUI N0000147760 NDFRT
PA D000900 MSH
PM 91; was see under CEPHALOSPORINS 1980-90 MSH
RN O1R9FJ93ED MSH
RR 55268-75-2 (Cefuroxime) MSH
RXAUI 2069465 RXNORM
RXAUI 3094234 RXNORM
RXAUI 3122950 RXNORM
RXAUI 3122951 RXNORM
RXAUI 3131158 RXNORM
RXAUI 3131159 RXNORM
RXAUI 3131577 RXNORM
RXAUI 3293262 RXNORM
RXAUI 6395196 RXNORM
RXAUI 6396141 RXNORM
RXAUI 67167 RXNORM
RXCUI 2194 RXNORM
SID APRD00285 DRUGBANK
SPL_SET_ID 0a145288-733a-4966-b7ae-dc96eb103d8c MTHSPL
SPL_SET_ID 0bfa8845-9664-450d-b268-5dbaa0301c40 MTHSPL
SPL_SET_ID 132c3d2a-423a-452c-9787-6615d5f8f21f MTHSPL
SPL_SET_ID 135e2dfc-eb47-4d04-a903-a081d36c267e MTHSPL
SPL_SET_ID 16a686e6-63f4-478f-a673-02dde9474eda MTHSPL
SPL_SET_ID 19902965-d2d6-433f-982d-0095014df4e8 MTHSPL
SPL_SET_ID 1bc56a86-735c-4787-826a-9bb59027fa09 MTHSPL
SPL_SET_ID 1c747919-7968-40aa-80b2-e2f7d499a801 MTHSPL
SPL_SET_ID 1f35ed70-4947-4d4d-b4c8-71ce520fc445 MTHSPL
SPL_SET_ID 1fd2babd-4737-45ad-9464-a7479a3816d9 MTHSPL
SPL_SET_ID 2722942a-7225-43bd-8814-52147fe6f7f2 MTHSPL
SPL_SET_ID 2af8f061-c0e1-3a1c-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2af94304-8118-41c7-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2c884d84-8a0c-4d6e-b523-6006ceeef225 MTHSPL
SPL_SET_ID 2f439b86-59d6-4350-aeb4-c904b3781db4 MTHSPL
SPL_SET_ID 376bb7f3-b938-4f80-9f68-f44bb88a3894 MTHSPL
SPL_SET_ID 42105671-ad7c-462c-b42f-1cdad94753d2 MTHSPL
SPL_SET_ID 5521cb28-aed1-4e3c-b2ef-65a1b524ff57 MTHSPL
SPL_SET_ID 56a09adc-f383-4d17-a87e-8dac32cbfa51 MTHSPL
SPL_SET_ID 59f19579-f813-4102-b030-c55505b3551b MTHSPL
SPL_SET_ID 5aa67341-d2fd-493d-ba58-0a0a573fb64a MTHSPL
SPL_SET_ID 5b6288fa-49da-4f44-b779-86e8404921db MTHSPL
SPL_SET_ID 61d3f51b-a8ed-4be5-849c-4bf653538d3e MTHSPL
SPL_SET_ID 65daa2aa-cc4a-4eba-b7dc-7a151806865a MTHSPL
SPL_SET_ID 66f8d37f-aebc-4435-af80-dfd7b3770088 MTHSPL
SPL_SET_ID 671351fb-2abe-4de3-9790-43c8dc3d760a MTHSPL
SPL_SET_ID 67573629-2151-42ae-8c46-d6b8d77d8378 MTHSPL
SPL_SET_ID 68e22782-f3a6-4e2c-8612-3f1608547919 MTHSPL
SPL_SET_ID 6ec17924-9107-4ef9-bfbd-b865e3091ed9 MTHSPL
SPL_SET_ID 703cc338-c0b6-4a02-b8db-c27aeff181df MTHSPL
SPL_SET_ID 708b7a4d-ba1f-47b5-be4d-a01c2a7017ff MTHSPL
SPL_SET_ID 710a5a3b-eca1-4a57-9d71-bd8d9953e48f MTHSPL
SPL_SET_ID 79f5cf6f-a5e2-49a2-9704-fa1bd21338c3 MTHSPL
SPL_SET_ID 7e7517b6-8f9f-4600-881a-9ed8bc1f454a MTHSPL
SPL_SET_ID 82d6ef8a-29cc-4bfb-8801-fdb8fd6f1ff8 MTHSPL
SPL_SET_ID 8cc2bf2e-d51f-4abd-bc08-660c5e5f00de MTHSPL
SPL_SET_ID 8dce5b09-9b27-457b-994e-0f7cad674a3c MTHSPL
SPL_SET_ID 98ea197c-b3ff-47bc-8d0f-fce91b539959 MTHSPL
SPL_SET_ID 9ccf0781-4fb3-496e-bd58-54381ea33510 MTHSPL
SPL_SET_ID a1c53a0c-78b0-4c6e-b2bc-0ee90cbe9e73 MTHSPL
SPL_SET_ID a7b50175-e978-4edd-9d61-593df4806657 MTHSPL
SPL_SET_ID a84ac4ed-c268-4e9f-9df8-256e0a64cd16 MTHSPL
SPL_SET_ID ad1a2f81-2595-47eb-9c2e-967c4b8e26bd MTHSPL
SPL_SET_ID ae5cdf54-3655-4d96-a67c-42eea8b721db MTHSPL
SPL_SET_ID afdcbab4-233b-47c4-a357-9eb46b41c68c MTHSPL
SPL_SET_ID bb2e8e50-02ae-68ec-1f26-ef949ec5ce8b MTHSPL
SPL_SET_ID bb93e48c-b988-4eac-83d5-1c82aeb951d1 MTHSPL
SPL_SET_ID dd11e4b9-7730-4d3a-81ca-16f15de09759 MTHSPL
SPL_SET_ID f1e044b6-eec2-4ad8-8384-37849a492d8e MTHSPL
SPL_SET_ID f4797359-d4a0-4967-86d3-d348518b3fe4 MTHSPL
SPL_SET_ID f799137f-9676-42d4-9130-a9685cc9302c MTHSPL
SPL_SET_ID faef39e9-d793-4191-a728-310f6fab759d MTHSPL
SPL_SET_ID fd79c41e-b0e9-47dc-a3ce-caacdc66bc96 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e68.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUW1X SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007134 MSH
TERMUI T007135 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USAN (1984) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2287^Active/Master NDFRT
VANDF_RECORD 50.6^82^Active/Master NDFRT
VUID 4019668 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007562

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