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Ceftriaxone (CUI C0007561) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007561

NCI Thesaurus Code: C62020  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

NCI-GLOSS Definition: An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.

MSH Definition: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, (6R-(6alpha,7beta(Z)))-
Cefatriaxone
Ceftriaxona
Ceftriaxone (substance)
Ceftriaxone [Chemical/Ingredient]
Ceftriaxone
Ceftriaxonum
Ceftriaxon
Ceftriazone
Product containing ceftriaxone (medicinal product)
Product containing ceftriaxone

External Source Codes: 
NCI Thesaurus Code C62020 (see NCI Thesaurus info)
CAS Registry Number 73384-59-5 (see NLM ChemIDplus info)
FDA UNII Code 75J73V1629

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:29007 NCI
Chemical_Formula C18H18N8O7S3 NCI
Contributing_Source FDA NCI
CTV3ID e6m.. SNOMEDCT_US
CTV3ID XUVys SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19860101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 75J73V1629 DRUGBANK
FDA_UNII_CODE 75J73V1629 NDFRT
HN 86 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19850606 MSH
MESH_DEFINITION A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears. NDFRT
MESH_DUI D002443 NDFRT
MESH_NAME Ceftriaxone NDFRT
MESH_UI M0003731 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.190.190.155 MSH
MN D02.886.665.074.190.190.155 MSH
MN D03.633.100.300.249.190.190.155 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005862 NDFRT
NUI N0000147759 NDFRT
PA D000900 MSH
PM 86 MSH
RN 75J73V1629 MSH
RR 023Z5BR09K MSH
RR 104376-79-6 (di-Na salt) MSH
RR 73384-59-5 (Ceftriaxone) MSH
RR 74578-69-1 (di-Na salt, anhydrous) MSH
RXAUI 2069464 RXNORM
RXAUI 3094246 RXNORM
RXAUI 3122916 RXNORM
RXAUI 3122917 RXNORM
RXAUI 3131098 RXNORM
RXAUI 3131151 RXNORM
RXAUI 3131152 RXNORM
RXAUI 3131155 RXNORM
RXAUI 3732755 RXNORM
RXAUI 6395128 RXNORM
RXAUI 6396140 RXNORM
RXAUI 67131 RXNORM
RXAUI 7247487 RXNORM
RXCUI 2193 RXNORM
SID APRD00395 DRUGBANK
SPL_SET_ID 02c0d5ad-555e-421f-9806-e903ac83499f MTHSPL
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SPL_SET_ID dac396fb-748d-45ea-9830-17c6eeb8834f MTHSPL
SPL_SET_ID dc28e719-6fe0-4d9e-a624-adb76b04b299 MTHSPL
SPL_SET_ID dc65a958-5c0d-4cd1-bbd1-f3d55a5251f2 MTHSPL
SPL_SET_ID de028434-46cf-44f6-8ac6-889c7c6943b3 MTHSPL
SPL_SET_ID dee5f207-4cfa-4b22-be11-44774a90fbcf MTHSPL
SPL_SET_ID e3485086-7a10-45fa-aa83-ee6fbbf39c59 MTHSPL
SPL_SET_ID e38c48f6-4d07-422b-9bb2-3c1025946e86 MTHSPL
SPL_SET_ID e6ac87e3-481e-4884-ac06-1fd7279cad62 MTHSPL
SPL_SET_ID f5d7ae2f-5485-42e2-af2b-bd7f06df85d7 MTHSPL
SPL_SET_ID f6705aaf-7ba7-45e4-bcd9-13d0ea77099f MTHSPL
SPL_SET_ID f72b2dd4-00f8-421c-88f5-f1517e27b21b MTHSPL
SPL_SET_ID fbcbc26e-7497-49b3-8828-5a0a5c34929b MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e6m.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVys SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007123 MSH
TERMUI T007124 MSH
TERMUI T007125 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2286^Active/Master NDFRT
VANDF_RECORD 50.6^182^Active/Master NDFRT
VUID 4019667 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007561

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