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Ceftazidime (CUI C0007559) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007559

NCI Thesaurus Code: C66868  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

MSH Definition: Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAZ
Ceftazidima
Ceftazidime (substance)
Ceftazidime [Chemical/Ingredient]
Ceftazidime pentahydrate (substance)
Ceftazidime Pentahydrate
Ceftazidime
Ceftazidimum
Ceftazidim
Ceptaz
Fortaz
GR 20263
GR-20263
GR20263
LY 139381
LY-139381
LY139381
Pentacef
Pentahydrate, Ceftazidime
Product containing ceftazidime (medicinal product)
Product containing ceftazidime
Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Hydroxide, Inner Salt, Pentahydrate, (6R-(6alpha,7beta(Z)))-
Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))-

External Source Codes: 
NCI Thesaurus Code C66868 (see NCI Thesaurus info)
CAS Registry Number 78439-06-2 (see NLM ChemIDplus info)
FDA UNII Code 9M416Z9QNR

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3509 NCI
Chemical_Formula C22H21N6O7S2."H".5H2O NCI
Contributing_Source FDA NCI
CTV3ID e66.. SNOMEDCT_US
CTV3ID XUvjY SNOMEDCT_US
CTV3ID XUWsW SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19850101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
EFFECTIVE_TIME 20170731 SNOMEDCT_US
FDA_UNII_CODE 9M416Z9QNR DRUGBANK
FDA_UNII_CODE 9M416Z9QNR NDFRT
HN 85 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19840524 MSH
MESH_DEFINITION Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients. NDFRT
MESH_DUI D002442 NDFRT
MESH_NAME Ceftazidime NDFRT
MESH_UI M0003729 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.210.150 MSH
MN D02.886.665.074.210.150 MSH
MN D03.633.100.300.249.210.150 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005860 NDFRT
NUI N0000145931 NDFRT
PA D000900 MSH
PM 85 MSH
RN 0 MSH
RN 9M416Z9QNR MSH
RR 78439-06-2 (Ceftazidime) MSH
RR DZR1ENT301 MSH
RXAUI 1176082 RXNORM
RXAUI 2069461 RXNORM
RXAUI 2622240 RXNORM
RXAUI 3122819 RXNORM
RXAUI 3122820 RXNORM
RXAUI 3131144 RXNORM
RXAUI 3131145 RXNORM
RXAUI 3226472 RXNORM
RXAUI 3266497 RXNORM
RXAUI 3732758 RXNORM
RXAUI 5911033 RXNORM
RXAUI 5911795 RXNORM
RXAUI 5930525 RXNORM
RXAUI 67065 RXNORM
RXCUI 215950 RXNORM
RXCUI 2191 RXNORM
RXCUI 235552 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SID APRD00857 DRUGBANK
SPL_SET_ID 112c5457-8d71-49f5-b531-9761d7d38c93 MTHSPL
SPL_SET_ID 1ab5ae3e-e303-4499-4c89-472d7cc1e46c MTHSPL
SPL_SET_ID 1b41f272-0727-4ce5-a4af-6255061a08b0 MTHSPL
SPL_SET_ID 22d6534c-4488-48a1-8d78-e2fb908259de MTHSPL
SPL_SET_ID 40d48c5d-650e-461b-a67b-7e65772d1b92 MTHSPL
SPL_SET_ID 6e454496-f924-4e04-bbeb-1c1fee7082cd MTHSPL
SPL_SET_ID 757c31dc-99ef-4960-b118-738b79631b1a MTHSPL
SPL_SET_ID 981b9abe-4c76-41b2-8f36-eb3e28fa5adc MTHSPL
SPL_SET_ID 9b73979c-c95a-4433-0a9d-f9cea3cb557f MTHSPL
SPL_SET_ID a32a9a03-03ac-45f2-8af5-f5481020144f MTHSPL
SPL_SET_ID aec64360-8452-4987-a366-a5a4f8762ab6 MTHSPL
SPL_SET_ID bcc81df2-20e3-4738-bfcf-301da883c1d9 MTHSPL
SPL_SET_ID bfd92fd8-3014-44dd-b69b-4276262a51fa MTHSPL
SPL_SET_ID d9c2803f-dc9c-4b19-b4a3-8303bc8c15fd MTHSPL
SPL_SET_ID fd2fa2af-5929-4152-afd3-55e4e162f765 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e66.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUvjY SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWsW SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007117 MSH
TERMUI T007118 MSH
TERMUI T007119 MSH
TERMUI T007120 MSH
TERMUI T845789 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (2014) MSH
TH UNK (19XX) MSH
TH USAN (1980) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^143^Active/Master NDFRT
VANDF_RECORD 50.6^81^Active/Master NDFRT
VUID 4017550 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007559

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