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Cefoxitin (CUI C0007557) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007557

NCI Thesaurus Code: C61665  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A semisynthetic, broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

MSH Definition: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7S)-3-[(Carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-methoxy-8-oxo-7-((2-thienylacetyl)amino)-, (6R-cis)-
Cefoxitin (substance)
Cefoxitin [Chemical/Ingredient]
Cefoxitina
Cefoxitine
Cefoxitinum
Cefoxitin
Ceftoxitin
Cephoxitin
CFX
Product containing cefoxitin (medicinal product)
Product containing cefoxitin

External Source Codes: 
NCI Thesaurus Code C61665 (see NCI Thesaurus info)
CAS Registry Number 35607-66-0 (see NLM ChemIDplus info)
FDA UNII Code 6OEV9DX57Y

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:209807 NCI
Chemical_Formula C16H17N3O7S2 NCI
Contributing_Source FDA NCI
CTV3ID e64.. SNOMEDCT_US
CTV3ID XUW0f SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19800101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 6OEV9DX57Y DRUGBANK
FDA_UNII_CODE 6OEV9DX57Y NDFRT
HN 80(75); was see under CEPHALOSPORINS 1975-79 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741119 MSH
MESH_DEFINITION A semisynthetic cephamycin antibiotic resistant to beta-lactamase. NDFRT
MESH_DUI D002440 NDFRT
MESH_NAME Cefoxitin NDFRT
MESH_UI M0003724 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.250.222 MSH
MN D02.886.665.074.250.222 MSH
MN D03.633.100.300.249.250.222 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005855 NDFRT
NUI N0000147757 NDFRT
PA D000900 MSH
PM 80; was see under CEPHALOSPORINS 1975-79 MSH
RN 6OEV9DX57Y MSH
RR 33564-30-6 (Cefoxitin Sodium) MSH
RR 35607-66-0 (Cefoxitin) MSH
RR Q68050H03T MSH
RXAUI 2069457 RXNORM
RXAUI 3094235 RXNORM
RXAUI 3122745 RXNORM
RXAUI 3122746 RXNORM
RXAUI 3131137 RXNORM
RXAUI 3131140 RXNORM
RXAUI 3723594 RXNORM
RXAUI 6395122 RXNORM
RXAUI 6395191 RXNORM
RXAUI 6396136 RXNORM
RXAUI 67003 RXNORM
RXCUI 2189 RXNORM
SID EXPT00897 DRUGBANK
SPL_SET_ID 2a9d1e7b-96ee-4e6c-a1e8-47b76b924422 MTHSPL
SPL_SET_ID 3671d786-9dc0-4779-8ff6-837e7f066259 MTHSPL
SPL_SET_ID 38fd8532-7fb4-45d6-b79d-000ffff85aa6 MTHSPL
SPL_SET_ID 4c6f7665-204f-6c69-7669-61204d756e6e MTHSPL
SPL_SET_ID 5b144573-6558-4e7a-9ee4-d0c3221dea42 MTHSPL
SPL_SET_ID 658a0dc6-6da5-44dc-94f2-1211619297f7 MTHSPL
SPL_SET_ID 6a4a2afa-4f00-41d4-bd6d-baa0a95f6929 MTHSPL
SPL_SET_ID 6c7e9485-1ede-411c-8c46-911439332864 MTHSPL
SPL_SET_ID 7ab61c2b-2d17-4a73-aed7-23e72076d11b MTHSPL
SPL_SET_ID 7ae80b51-b62d-4adf-be6a-9d320cd97c76 MTHSPL
SPL_SET_ID b272ef9c-4d83-4ee2-b9cc-477440822cca MTHSPL
SPL_SET_ID d02170ff-65aa-48b8-a922-94271c46ffa7 MTHSPL
SPL_SET_ID d2c449b9-5624-4166-95b1-d7813b3d0445 MTHSPL
SPL_SET_ID ea6dba56-5d9c-463a-b1d9-f7af5b602ed9 MTHSPL
SPL_SET_ID f5288962-caee-4771-8229-df9cdefcfa67 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e64.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUW0f SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007106 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USAN (1973) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2284^Active/Master NDFRT
VANDF_RECORD 50.6^302^Active/Master NDFRT
VUID 4019665 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007557

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