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Cefotaxime (CUI C0007554) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007554

NCI Thesaurus Code: C354  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.

PDQ Definition: A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for active clinical trials using this agent. (NCI Thesaurus)

MSH Definition: Semisynthetic broad-spectrum cephalosporin.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-3-(Acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R,Z)-3-(Acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-
63527-52-6
Cefotaxima
Cefotaxime (substance)
Cefotaxime [Chemical/Ingredient]
Cefotaxime
Cefotaximum
Cefotaxim
Cephotaxime
Cephotaxim
Claforan
CĂ©fotaxime
Product containing cefotaxime (medicinal product)
Product containing cefotaxime

External Source Codes: 
NCI Thesaurus Code C354 (see NCI Thesaurus info)
CAS Registry Number 63527-52-6 (see NLM ChemIDplus info)
FDA UNII Code N2GI8B1GK7
PDQ Closed Trial Search ID 39177
PDQ Open Trial Search ID 39177 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:204928 NCI
Chemical_Formula C16H17N5O7S2 NCI
Contributing_Source FDA NCI
CTV3ID e63.. SNOMEDCT_US
CTV3ID XUVzQ SNOMEDCT_US
DATE_LAST_MODIFIED 2006-12-12 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19820101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE N2GI8B1GK7 DRUGBANK
FDA_UNII_CODE N2GI8B1GK7 NDFRT
HN 82 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MTH
LT TRD PDQ
MDA 19810513 MSH
MESH_DEFINITION Semisynthetic broad-spectrum cephalosporin. NDFRT
MESH_DUI D002439 NDFRT
MESH_NAME Cefotaxime NDFRT
MESH_UI M0003722 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.190.190 MSH
MN D02.886.665.074.190.190 MSH
MN D03.633.100.300.249.190.190 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C354 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005835 NDFRT
NUI N0000147755 NDFRT
ORIG_STY Drug/agent PDQ
PA D000900 MSH
PID 1797 PDQ
PM 82 MSH
RN N2GI8B1GK7 MSH
RR 258J72S7TZ MSH
RR 63527-52-6 (Cefotaxime) MSH
RR 64485-93-4 (mono-Na salt) MSH
RXAUI 1910604 RXNORM
RXAUI 2069455 RXNORM
RXAUI 3094236 RXNORM
RXAUI 3122700 RXNORM
RXAUI 3122701 RXNORM
RXAUI 3131125 RXNORM
RXAUI 3131126 RXNORM
RXAUI 3131129 RXNORM
RXAUI 3131574 RXNORM
RXAUI 6395120 RXNORM
RXAUI 6395189 RXNORM
RXAUI 6396134 RXNORM
RXAUI 66908 RXNORM
RXCUI 203573 RXNORM
RXCUI 2186 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00854 DRUGBANK
SPL_SET_ID 06de783b-0762-4031-991e-2e726da33e16 MTHSPL
SPL_SET_ID 4ebb9704-6b9f-4b47-aac4-d54fe34f0b83 MTHSPL
SPL_SET_ID 7130d493-21fb-4d1d-bae0-4b906fd34023 MTHSPL
SPL_SET_ID a401a44e-2c5c-4c4a-81d8-56a3ef9d57f7 MTHSPL
SPL_SET_ID da74aee2-4596-4a41-a061-b9a2a487adb0 MTHSPL
SPL_SET_ID ed23b6bc-32c7-4c50-a53d-313ae78e5623 MTHSPL
SPL_SET_ID ef1a6dc6-bc3d-4f09-8f92-7ff328f56561 MTHSPL
SPL_SET_ID f3c5895f-f54b-43d4-9b38-7bfbdf8335b7 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e63.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVzQ SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007098 MSH
TERMUI T007099 MSH
TERMUI T007100 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2282^Active/Master NDFRT
VANDF_RECORD 50.6^776^Active/Master NDFRT
VUID 4019663 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007554

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