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Cefonicid (CUI C0007551) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007551

NCI Thesaurus Code: C65299  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A second-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefonicid binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

MSH Definition: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-8-oxo-3-(((1-(sulfomethyl)-1H-tetrazol-5-yl)thio)methyl)-, (6R-(6alpha,7beta(R*)))-
Cefonicid (substance)
Cefonicid [Chemical/Ingredient]
Cefonicido
Cefonicidum
Cefonicid
Product containing cefonicid (medicinal product)
Product containing cefonicid

External Source Codes: 
NCI Thesaurus Code C65299 (see NCI Thesaurus info)
CAS Registry Number 61270-58-4 (see NLM ChemIDplus info)
FDA UNII Code 6532B86WFG

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3491 NCI
Chemical_Formula C18H18N6O8S3 NCI
Contributing_Source FDA NCI
CTV3ID XUGyI SNOMEDCT_US
CTV3ID XUUW1 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19900101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 6532B86WFG DRUGBANK
FDA_UNII_CODE 6532B86WFG NDFRT
HN 90 MSH
LEVEL Ingredient NDFRT
MDA 19890525 MSH
MESH_DEFINITION A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. NDFRT
MESH_DUI D015790 NDFRT
MESH_NAME Cefonicid NDFRT
MESH_UI M0024188 NDFRT
MMR 20160528 MSH
MN D02.065.589.099.249.177 MSH
MN D02.886.665.074.177 MSH
MN D03.633.100.300.249.177 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006564 NDFRT
NUI N0000147753 NDFRT
PA D000900 MSH
PM 90 MSH
RN 6532B86WFG MSH
RR 61270-58-4 (Cefonicid) MSH
RR 61270-78-8 (di-Na salt) MSH
RR 71420-79-6 (mono-Na salt) MSH
RR QD9G66C5UF MSH
RXAUI 2069444 RXNORM
RXAUI 3094255 RXNORM
RXAUI 3122655 RXNORM
RXAUI 3122656 RXNORM
RXAUI 3131114 RXNORM
RXAUI 3131118 RXNORM
RXAUI 66841 RXNORM
RXCUI 2183 RXNORM
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUGyI SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUUW1 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T046823 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1990) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2280^Active/Master NDFRT
VANDF_RECORD 50.6^337^Active/Master NDFRT
VUID 4019661 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007551

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