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Cefazolin (CUI C0007546) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0007546

NCI Thesaurus Code: C28913  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

MSH Definition: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid
(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-
Cefazolin (substance)
Cefazolin [Chemical/Ingredient]
Cefazolina
Cefazoline
Cefazolinum
Cefazolin
Cephazolidin
Cephazoline
Cephazolin
CEZ
Product containing cefazolin (medicinal product)
Product containing cefazolin

External Source Codes: 
NCI Thesaurus Code C28913 (see NCI Thesaurus info)
CAS Registry Number 25953-19-9 (see NLM ChemIDplus info)
FDA UNII Code IHS69L0Y4T

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:474053 NCI
Chemical_Formula C14H14N8O4S3 NCI
Contributing_Source FDA NCI
CTV3ID e6c.. SNOMEDCT_US
CTV3ID XUWwu SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19800101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE IHS69L0Y4T DRUGBANK
FDA_UNII_CODE IHS69L0Y4T NDFRT
HN 80(75); was see under CEPHALOSPORINS 1975-79 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741111 MSH
MESH_DEFINITION A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. NDFRT
MESH_DUI D002437 NDFRT
MESH_NAME Cefazolin NDFRT
MESH_UI M0003718 NDFRT
MMR 20160527 MSH
MN D02.065.589.099.249.160 MSH
MN D02.886.665.074.160 MSH
MN D03.633.100.300.249.160 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005828 NDFRT
NUI N0000147751 NDFRT
PA D000900 MSH
PM 80; was see under CEPHALOSPORINS 1975-79 MSH
RN IHS69L0Y4T MSH
RR 25953-19-9 (Cefazolin) MSH
RR 27164-46-1 (Cefazolin Sodium) MSH
RR P380M0454Z MSH
RXAUI 2069436 RXNORM
RXAUI 3094233 RXNORM
RXAUI 3122545 RXNORM
RXAUI 3122546 RXNORM
RXAUI 3131101 RXNORM
RXAUI 3131104 RXNORM
RXAUI 3131572 RXNORM
RXAUI 3723591 RXNORM
RXAUI 6395116 RXNORM
RXAUI 6395188 RXNORM
RXAUI 6396132 RXNORM
RXAUI 66747 RXNORM
RXCUI 2180 RXNORM
SPL_SET_ID 06091653-e568-4e82-acc7-aefbce16de17 MTHSPL
SPL_SET_ID 13a33420-b1e1-4b7e-8e59-4d5badafe654 MTHSPL
SPL_SET_ID 17f8f038-c204-4dab-80d7-6f7ac41ddbec MTHSPL
SPL_SET_ID 18e7366a-1b3e-4010-8f4a-dd559d4f2146 MTHSPL
SPL_SET_ID 1999084a-124c-45f9-801f-416a1b942c96 MTHSPL
SPL_SET_ID 1dc9de56-e259-4546-a1db-23119a8a088e MTHSPL
SPL_SET_ID 23b1c967-cb7c-4087-901e-0cfef6e9ad97 MTHSPL
SPL_SET_ID 3494332d-3e3f-4ec5-82e9-38fd6107f32a MTHSPL
SPL_SET_ID 3739729d-a52e-4226-a2f0-ee0e5ee6a401 MTHSPL
SPL_SET_ID 47a8928f-708d-418a-829b-36eded96bac0 MTHSPL
SPL_SET_ID 48656c70-206d-652c-204f-62692d57616e MTHSPL
SPL_SET_ID 614d0d33-2886-48aa-9c12-a9a1a205d8d8 MTHSPL
SPL_SET_ID 618b6e70-8562-45b7-8742-9bd4855e3ffb MTHSPL
SPL_SET_ID 62441488-fc97-4535-a249-4485fb075022 MTHSPL
SPL_SET_ID 63039a37-f429-4359-bc8d-08efe3fe280e MTHSPL
SPL_SET_ID 686cd696-0011-47b2-b342-142c20169ac6 MTHSPL
SPL_SET_ID 6b9d7316-ae8a-49fd-b5cf-95c9810adcb9 MTHSPL
SPL_SET_ID 6ee638ed-2d83-4318-a7f8-dd0e26b5f038 MTHSPL
SPL_SET_ID 77aad3eb-74be-4ee4-957a-16cffa3b96af MTHSPL
SPL_SET_ID 79afc719-8279-49f9-83b0-e0736c07eb5c MTHSPL
SPL_SET_ID 807b03ea-e6c4-4165-991e-8cce036eba8f MTHSPL
SPL_SET_ID 8723966e-1227-451c-8b24-1b0c9275c154 MTHSPL
SPL_SET_ID 976916CA-85FA-4099-9607-FD377E9CF319 MTHSPL
SPL_SET_ID a1ca2a2e-c860-4031-8276-be86be6a72ea MTHSPL
SPL_SET_ID a43260a4-f4ec-4331-aa80-02e584be7af5 MTHSPL
SPL_SET_ID a61c72ee-f63b-482b-b4cc-15af4fa20ded MTHSPL
SPL_SET_ID aa5a2299-3892-4461-9c3d-47b0492f8e19 MTHSPL
SPL_SET_ID ac323b5b-132a-4513-927e-2c38b6d33d71 MTHSPL
SPL_SET_ID ad091584-9b96-488d-89bc-09b07986c7bb MTHSPL
SPL_SET_ID bd48e816-d63f-4855-baad-c02f529bdf2a MTHSPL
SPL_SET_ID c47c8d14-1eef-40f9-9d11-f0c300b1d4be MTHSPL
SPL_SET_ID c71eee24-acd2-436f-bf06-44358e602bf8 MTHSPL
SPL_SET_ID cac0686d-d7fa-4bdf-8a0d-c653a5b2d136 MTHSPL
SPL_SET_ID cf13db9c-d8a1-489f-9aa0-fc70839d4bbc MTHSPL
SPL_SET_ID cfe38cdf-64a1-4e22-8bba-b463d18447d3 MTHSPL
SPL_SET_ID d12fb92d-1dc5-4a46-ac25-bf4d3da8f937 MTHSPL
SPL_SET_ID d3fe1e18-9e3e-4797-9fb4-275900fa9ff3 MTHSPL
SPL_SET_ID d91a8d13-99a0-4d87-88dc-71cbd37922b4 MTHSPL
SPL_SET_ID db977f52-2296-4003-9162-c155163d714a MTHSPL
SPL_SET_ID e117f4c9-50d9-4ab0-ad16-9f17f1dab59a MTHSPL
SPL_SET_ID e3b4b623-360a-405f-93c8-38c8ad52dd03 MTHSPL
SPL_SET_ID e48fcd44-243f-4af0-ae45-47db4a8687b9 MTHSPL
SPL_SET_ID e58f87fb-a47d-4081-a454-e4e916e2f629 MTHSPL
SPL_SET_ID e6e9b2a9-6650-497f-b8ff-66c092f2f3b2 MTHSPL
SPL_SET_ID e8bd9e95-8af5-416b-b58c-e1dbe3d052ac MTHSPL
SPL_SET_ID e8f40f72-3cf0-43dc-a797-fb98dd8af228 MTHSPL
SPL_SET_ID f17160d4-fc42-4f9c-abb8-d04f01ae6dd1 MTHSPL
SPL_SET_ID fae6b455-db4f-4250-a700-794f8a699960 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~e6c.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWwu SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T007080 MSH
TERMUI T007081 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2278^Active/Master NDFRT
VANDF_RECORD 50.6^30^Active/Master NDFRT
VUID 4019659 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0007546

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