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Capsaicin (CUI C0006931) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0006931

NCI Thesaurus Code: C339  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.

NCI-GLOSS Definition: A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. Also being studied for controlling mucositis pain after chemotherapy and radiation therapy.

CRCH Definition: Capsaicinoid compound with side chain CO(CH2)4(CH)2CH(CH3)2. The chemical structure is CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC.

CSP Definition: N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection.

MSH Definition: An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.

Synonyms & Abbreviations: (see Synonym Details)
(E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide
(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-
8 Methyl N Vanillyl 6 Nonenamide
8-Methyl-N-Vanillyl-6-Nonenamide
Capsaicin (substance)
Capsaicin [Chemical/Ingredient]
Capsaicine
capsaicin
Capsciecin
N-(4-hydroxy-3-methoxyphenylmethyl) -8-Methyl-6-Nonenamide
Product containing capsaicin (medicinal product)
Product containing capsaicin

External Source Codes: 
NCI Thesaurus Code C339 (see NCI Thesaurus info)
CAS Registry Number 404-86-4 (see NLM ChemIDplus info)
FDA UNII Code S07O44R1ZM
NSC Code 56353 (see NCI DTP info)
PDQ Closed Trial Search ID 41591
PDQ Open Trial Search ID 41591 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3374 NCI
Chemical_Formula C18H27NO3 NCI
Contributing_Source CRCH NCI
Contributing_Source FDA NCI
CTV3ID X7956 SNOMEDCT_US
CTV3ID XUZ5e SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 4000-0137 CSP
DX 19840101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030731 SNOMEDCT_US
FDA_UNII_CODE S07O44R1ZM DRUGBANK
FDA_UNII_CODE S07O44R1ZM NDFRT
HN 1984(1975) MSH
HN Introduced 1995. AOD
LEVEL Ingredient NDFRT
MDA 19741127 MSH
MESH_DEFINITION An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS. NDFRT
MESH_DUI D002211 NDFRT
MESH_NAME Capsaicin NDFRT
MESH_UI M0003308 NDFRT
MMR 20160701 MSH
MN D02.065.160.500 MSH
MN D02.455.326.271.060.222 MSH
MN D02.455.426.559.389.657.166.099 MSH
MN D03.132.760.200 MSH
MN D10.251.355.325.190 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C339 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007430 NDFRT
NUI N0000147626 NDFRT
ORIG_STY Drug/agent PDQ
PA D000982 MSH
PA D018689 MSH
PID 4754 PDQ
PM 1984; see FATTY ACIDS, UNSATURATED 1975-1983; NGX-4010 was indexed under CAPSAICIN 2009 MSH
RN S07O44R1ZM MSH
RR 404-86-4 (Capsaicin) MSH
RXAUI 2068801 RXNORM
RXAUI 3051157 RXNORM
RXAUI 3062222 RXNORM
RXAUI 3094435 RXNORM
RXAUI 3094624 RXNORM
RXAUI 3120814 RXNORM
RXAUI 3120815 RXNORM
RXAUI 3129829 RXNORM
RXAUI 3129832 RXNORM
RXAUI 3129834 RXNORM
RXAUI 3506942 RXNORM
RXAUI 60806 RXNORM
RXCUI 1992 RXNORM
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SPL_SET_ID e2041558-6091-4093-9fc6-44a93df3f0d4 MTHSPL
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SPL_SET_ID f1ab739d-bad5-49f2-8c0a-7688aef64d9b MTHSPL
SPL_SET_ID f1df49e4-aabd-4295-a0c7-4574695dc253 MTHSPL
SPL_SET_ID f22bda73-8df0-4427-bb01-b0820b7db31a MTHSPL
SPL_SET_ID f34aa9d9-f64c-49f3-9e8b-feb7ad1316b0 MTHSPL
SPL_SET_ID f400d68c-0fd1-401a-88b8-3ee3b0cbae56 MTHSPL
SPL_SET_ID f418e0db-6baf-48fb-a023-1d1bf3a1b848 MTHSPL
SPL_SET_ID f8f8d9b6-0781-4a42-ab03-3fd2e8ea59ba MTHSPL
SPL_SET_ID fc3314e9-515c-4c72-8781-ffa1c1246ace MTHSPL
SPL_SET_ID fc4f4081-b332-4083-aa99-e70c8e4e5005 MTHSPL
SPL_SET_ID fc5abe34-edf6-400a-bd28-1aea8bac8c70 MTHSPL
SPL_SET_ID fe6085cd-2788-4620-974a-b7d2ebe64712 MTHSPL
SPL_SET_ID fea8eecc-594e-400b-9f1c-f888dbcd2b0b MTHSPL
SPL_SET_ID fff5fae5-511d-4945-9d50-c30d78236029 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X7956 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUZ5e SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T006312 MSH
TERMUI T006313 MSH
TERMUI T006314 MSH
TH FDA SRS (2014) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2120^Active/Master NDFRT
VANDF_RECORD 50.6^2151^Active/Master NDFRT
VUID 4019506 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0006931

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