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Malignant Neoplasms (CUI C0006826) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0006826

NCI Thesaurus Code: C9305  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas.

PDQ Definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. Check for active clinical trials using this agent. (NCI Thesaurus)

MEDLINEPLUS Definition: 

Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for where they start. For example, lung cancer starts in the lung, and breast cancer starts in the breast. The spread of cancer from one part of the body to another is called metastasis. Symptoms and treatment depend on the cancer type and how advanced it is. Most treatment plans may include surgery, radiation and/or chemotherapy. Some may involve hormone therapy, biologic therapy, or stem cell transplantation.

NIH: National Cancer Institute

CDISC Definition: A general term for autonomous tissue growth exhibiting morphologic features of malignancy (e.g. severe atypia, nuclear pleomorphism, tumor cell necrosis, abnormal mitoses, tissue invasiveness) and for which the transformed cell type has not been specifically identified.

NCI-GLOSS Definition: A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Malignant cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of malignancy. Carcinoma is a malignancy that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a malignancy that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a malignancy that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are malignancies that begin in the cells of the immune system. Central nervous system cancers are malignancies that begin in the tissues of the brain and spinal cord.

NICHD Definition: Uncontrolled growth of abnormal cells with potential for metastatic spread.

CSP Definition: new abnormal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease; tumors perform no useful body function and may be benign or malignant; benign neoplasms are a noncancerous growth that does not invade nearby tissue or spread to other parts of the body; malignant neoplasms or cancer show a greater degree of anaplasia and have the properties of invasion and metastasis; neoplasm terms herein do not distinguish between benign or malignant states, use references listed to cover this concept.

Synonyms & Abbreviations: (see Synonym Details)
CA - Cancer
CANCER (NOS)
Cancer NOS
Cancer, unspecified site
Cancers
cancer
CA
MALIGNANCIES
Malignancy, unspecified site
Malignancy
Malignant Growth
Malignant neoplasm NOS
Malignant neoplasm without specification of site
Malignant neoplasm, unspecified
Malignant neoplasms
malignant neoplasm
Malignant neoplastic disease (disorder)
Malignant Neoplastic Disease
malignant tumoral disease
malignant tumor
Malignant tumour
NEOPLASM MALIGNANT
NEOPLASM, MALIGNANT
neoplasm/cancer
Tumor, malignant, NOS
Unclassified tumor, malignant

External Source Codes: 
NCI Thesaurus Code C9305 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CITE Playbook RADLEX
Contributing_Source CDISC NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID XUPna SNOMEDCT_US
DATE_CREATED 10/22/1998 MEDLINEPLUS
DATE_LAST_MODIFIED 2012-05-07 PDQ
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 2000-0173 CSP
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 malignant carcinoid tumor of unspecified site (C7A.00) ICD10CM
EXCLUDES1 malignant neoplasm of specified multiple sites- code to each site ICD10CM
EXTERNALLY_DEFINED N LNC
HN Changed descriptor 2000; through 1999 use "neoplastic disease." AOD
IAN DEFAULT ICD10
ICD-O-3_Code 8000/3 NCI
INCLUSION_TERM Cancer NOS ICD10
INCLUSION_TERM Carcinoma NOS ICD10
INCLUSION_TERM Malignancy NOS ICD10
INCLUSION_TERM Malignant cachexia NOS ICD10
INCLUSION_TERM Multiple cancer NOS ICD10
MP_GROUP_URL https://www.nlm.nih.gov/medlineplus/cancers.html MEDLINEPLUS
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/cancer.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Arabic https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Arabic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Bosnian https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Bosnian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/cancer.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hindi https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Hindi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Japanese https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Japanese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Khmer https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Khmer MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Korean https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Korean MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Portuguese https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Portuguese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/cancer.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Tagalog https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Tagalog MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Ukrainian https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Ukrainian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Vietnamese https://www.nlm.nih.gov/medlineplus/languages/cancer.html#Vietnamese MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Cancer Institute http://www.nci.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C9305 PDQ
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Cancer NCI
ORDER_NO 02158 ICD10CM
ORIG_STY Neoplasm diagnosis PDQ
PID 41 PDQ
PRIMARY_PATH 10028997$10029105$10027655$10029104$Neoplasm malignant$Neoplasms malignant site unspecified NEC$Miscellaneous and site unspecified neoplasms malignant and unspecified$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SOS Excludes: malignant carcinoid tumor of unknown primary site (209.20); malignant (poorly differentiated) neuroendocrine tumor, any site (209.30); neuroendocrine carcinoma (high grade), any site (209.30); malignant (poorly differentiated) neuroendocrine carcinoma, any site (209.30) ICD9CM
SOS Neoplasms are classified here by histologic and topologic characteristics. AOD
SOS Use for malignant tumoral processes in humans or animals. Use *GG20.20 neoplasia* for general tumor formation and growth processes. For the ETOH database, for specific cancers, combine *+GG20.28 cancer* and the appropriate body part from section X (e.g., for breast cancer, index *+GG20.28 cancer* and *+XH4.6 breast*). AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C80.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C80.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C80.1 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C80.1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUPna SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T000898778 MSH
TERMUI T027925 MSH
TH BIOETHICS (1974) MSH
TH NLM (2017) MSH
TH POPLINE (1978) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0006826

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