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Calcitriol (CUI C0006674) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0006674

NCI Thesaurus Code: C330  (see NCI Thesaurus info)

Semantic Type: Vitamin

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04)

PDQ Definition: A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: The active form of vitamin D. Calcitriol is formed in the kidneys or made in the laboratory. It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders.

CSP Definition: most biologically active metabolite of cholecalciferol; acts via a DNA-binding steroid receptor which induces transcription of calcium transport factors in gut; USP drug (calcitriol) is given as an antihypocalcemic.

MSH Definition: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

Synonyms & Abbreviations: (see Synonym Details)
(1alpha,3beta,5Z,7e)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
(1S,3R,5Z,7e)-9,10-Secocholesta-5,7,10-triene-1,3,25-triol
(5Z,7e)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
1 alpha,25 Dihydroxycholecalciferol
1 alpha,25 Dihydroxyvitamin D3
1 alpha,25-Dihydroxycholecalciferol
1 alpha,25-Dihydroxyvitamin D3
1,25 dihydroxycholecalciferol
1,25 Dihydroxyvitamin D3
1,25(OH)2 D3 preparation
1,25(OH)2-D3
1,25(OH)<sub>2</sub>D<sub>3</sub> preparation
1,25(OH)>2<D>3< preparation
1,25-DHCC - 1,25-Dihydroxycholecalciferol
1,25-DHCC
1,25-dihydroxycholecalciferol
1,25-Dihydroxycholecaliferol
1,25-Dihydroxyvitamin D3 (substance)
1,25-Dihydroxyvitamin D3
1,25-diOHCC - 1,25-Dihydroxycholecalciferol
1-alpha-25-Dihydroxyvitamin D3
1alpha,25(OH)2D3
1alpha,25-Dihydroxycholecalciferol
1alpha,25-Dihydroxyvitamin D3
1α,25(OH)2D3
1α,25-dihydroxycholecalciferol
1α,25-dihydroxyvitamin D3
32222-06-3
5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-
[VT502] CALCITRIOL
Abbott Brand of Calcitriol
alpha,25-Dihydroxyvitamin D3, 1
Calcijex
Calcitriol [Chemical/Ingredient]
Calcitriol Abbott Brand
Calcitriol Drug Class
Calcitriol Roche Brand
Calcitriolum
calcitriol
CALTROL
D3, 1 alpha,25-Dihydroxyvitamin
D3, 1,25-Dihydroxyvitamin
DIHYDROXYCHOLECALCIFEROL 01 25
DIHYDROXYCHOLECALCIFEROL 01 ALPHA 25
DIHYDROXYVITAMIN D3 01 25
DIHYDROXYVITAMIN D3 01 ALPHA 25
Hoffmann La Roche Brand of Calcitriol
Hoffmann-La Roche Brand of Calcitriol
Product containing calcitriol (medicinal product)
Product containing calcitriol
Rocaltrol
Roche Brand of Calcitriol

External Source Codes: 
NCI Thesaurus Code C330 (see NCI Thesaurus info)
CAS Registry Number 32222-06-3 (see NLM ChemIDplus info)
FDA UNII Code FXC9231JVH
PDQ Closed Trial Search ID 41919
PDQ Open Trial Search ID 41919 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Hyperparathyroidism; Hypocalcemia NCI
ACTIVE 1 SNOMEDCT_US
AN deficiency: coordinate CALCITRIOL /defic (IM) with VITAMIN D DEFICIENCY (IM) MSH
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:17823 NCI
Chemical_Formula C27H44O3 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID ip2.. SNOMEDCT_US
CTV3ID X80Es SNOMEDCT_US
DATE_LAST_MODIFIED 2006-07-27 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-7686 CSP
DRUG_CLASS_TYPE 2 VANDF
DX 19820101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FDA_UNII_CODE FXC9231JVH DRUGBANK
FDA_UNII_CODE FXC9231JVH NDFRT
FX D018167 MSH
HN 82 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LEVEL VA Class NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19810512 MSH
MESH_DEFINITION The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. NDFRT
MESH_DUI D002117 NDFRT
MESH_NAME Calcitriol NDFRT
MESH_UI M0003148 NDFRT
MMR 20160527 MSH
MN D04.210.500.247.222.159.478.387.300 MSH
MN D04.210.500.247.808.146.478.387.300 MSH
MN D04.210.500.812.768.196.478.387.300 MSH
MN D10.570.938.146.478.387.300 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C330 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006511 NDFRT
NUI N0000029459 NDFRT
NUI N0000146161 NDFRT
ORIG_STY Drug/agent PDQ
PA D002120 MSH
PA D014815 MSH
PA D050071 MSH
PARENT_CLASS 225 VANDF
PID 5139 PDQ
PM 82 MSH
RN 0 MSH
RN FXC9231JVH MSH
RR 32222-06-3 (Calcitriol) MSH
RXAUI 1000164 RXNORM
RXAUI 1001806 RXNORM
RXAUI 2068749 RXNORM
RXAUI 2598496 RXNORM
RXAUI 2621347 RXNORM
RXAUI 2627329 RXNORM
RXAUI 2658890 RXNORM
RXAUI 3090980 RXNORM
RXAUI 3090981 RXNORM
RXAUI 3091133 RXNORM
RXAUI 3091137 RXNORM
RXAUI 3094658 RXNORM
RXAUI 3119934 RXNORM
RXAUI 3119935 RXNORM
RXAUI 3119936 RXNORM
RXAUI 3128983 RXNORM
RXAUI 3128986 RXNORM
RXAUI 3257959 RXNORM
RXAUI 57902 RXNORM
RXCUI 151471 RXNORM
RXCUI 152323 RXNORM
RXCUI 1551644 RXNORM
RXCUI 1894 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00246 DRUGBANK
SID NUTR00003 DRUGBANK
SPL_SET_ID 045f46c7-c637-443b-8427-c461b3d7ca55 MTHSPL
SPL_SET_ID 167a669f-7b7e-46ea-9331-567bf19d8787 MTHSPL
SPL_SET_ID 1b2aa7df-0f38-460e-b1f1-d7473be4ab3c MTHSPL
SPL_SET_ID 2d755a21-9f42-4d36-aaec-962495ab2f2b MTHSPL
SPL_SET_ID 3289b482-8733-484d-b1db-d7f4cdcd1ac2 MTHSPL
SPL_SET_ID 362ec5a9-a269-4300-ae8f-f454252cf169 MTHSPL
SPL_SET_ID 406151ad-6c0a-4d66-86fc-e076df9671a3 MTHSPL
SPL_SET_ID 4d6046c2-4a28-47b1-9bb4-51fadeded2d2 MTHSPL
SPL_SET_ID 517f23e8-4ad5-46e7-8dc4-473d5dcb09c8 MTHSPL
SPL_SET_ID 63d26a82-4b79-44ce-52a4-395e4368acd4 MTHSPL
SPL_SET_ID 66a69351-5b09-4368-a9fa-acf81b5ad882 MTHSPL
SPL_SET_ID 7fa4ab07-3d8e-4300-91f3-b1e17cba8691 MTHSPL
SPL_SET_ID 81f14b75-2edb-45b4-82e2-47c8ef2c7a2e MTHSPL
SPL_SET_ID 82b2fffd-4a1f-4ea3-b156-b8dc51bfde52 MTHSPL
SPL_SET_ID 84262b69-df29-41d0-9e97-6e1188096aeb MTHSPL
SPL_SET_ID 9487fc57-5665-450d-adfa-8635e22483f9 MTHSPL
SPL_SET_ID a1567da9-af74-4afd-9ac5-8b53ec5d7cbf MTHSPL
SPL_SET_ID a86ea01b-51c2-49cb-965a-4659658d0a98 MTHSPL
SPL_SET_ID aaf62f0f-bd93-43f1-96f2-e4f001ea7328 MTHSPL
SPL_SET_ID add1e536-b6ed-4ba1-abd6-084b6845e3a4 MTHSPL
SPL_SET_ID ae2d0165-1b19-4406-9f28-f4b1579c3dbf MTHSPL
SPL_SET_ID bebefb2a-7365-48e2-9681-83ed4b41e26e MTHSPL
SPL_SET_ID c64778c6-3be6-44f5-8387-ebcd82e3eae5 MTHSPL
SPL_SET_ID cdcaffc6-e14e-4607-b77b-fc78a8382f60 MTHSPL
SPL_SET_ID d1013494-bf62-4e68-9f0c-e6571137f20f MTHSPL
SPL_SET_ID d3d69786-ac48-4a71-bbd8-83172e86d577 MTHSPL
SPL_SET_ID DC293A1C-995D-40FA-AC99-68DF12EB6D9E MTHSPL
SPL_SET_ID e26e13c4-7e45-4e66-8c0d-7fc68e24cdd5 MTHSPL
SPL_SET_ID ea59acf8-982e-43a7-872b-8ffc7d9e4e74 MTHSPL
SPL_SET_ID ec93b667-aad2-4e3a-adc6-952f070a0c0a MTHSPL
SPL_SET_ID f3b180dd-6c0b-4c15-85d3-bbbb5176d1d1 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~ip2.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80Es SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T006010 MSH
TERMUI T006011 MSH
TERMUI T006012 MSH
TERMUI T006013 MSH
TERMUI T006014 MSH
TERMUI T006021 MSH
TERMUI T589022 MSH
TERMUI T589023 MSH
TERMUI T589026 MSH
TERMUI T589027 MSH
TH AU MSH
TH BAN (19XX) MSH
TH CA MSH
TH DE MSH
TH ES MSH
TH FDA SRS (2014) MSH
TH FR MSH
TH IE MSH
TH INN (19XX) MSH
TH JAN (19XX) MSH
TH MX MSH
TH NLM (2005) MSH
TH NL MSH
TH UNK (19XX) MSH
TH USAN (1978) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VAC VT502 NDFRT
VAC VT502 VANDF
VANDF_RECORD 50.416^395^Active/Master NDFRT
VANDF_RECORD 50.605^429^Active/Master NDFRT
VANDF_RECORD 50.6^168^Active/Master NDFRT
VUID 4017800 NDFRT
VUID 4021906 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0006674

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