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Burkitt Lymphoma (CUI C0006413) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0006413

NCI Thesaurus Code: C2912  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures. It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients. Three morphologic variants are recognized: classical Burkitt lymphoma, Burkitt lymphoma with plasmacytoid differentiation, and atypical Burkitt/Burkitt-like lymphoma. All cases express the MYC translocation [t(8;14)]. (WHO, 2001)

GARD Definition: Burkitt lymphoma (BL) is a rare, aggressive form of B-cell non-Hodgkin's lymphoma, a type of cancer that affects the organs of the immune system. It is more common in males than females. Three forms exist: one endemic to Africa that is linked to the Epstein Barr virus (EBV); a sporadic form that develops mainly in the abdomen; and an immunodeficiency-associated form that occurs most commonly in individuals with HIV infection. BL can also develop in the ear, nose, throat and more rarely in other locations. Signs and symptoms may differ depending on the form of BL and the organs or body systems affected. The exact cause of the condition is not known. Treatment typically includes a few months of intensive chemotherapy; the current cure rate is estimated to be about 80-90%. - this information is from GARD/ORDR/NCATS.

HPO Definition: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. []

NCI-GLOSS Definition: An aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma that occurs most often in children and young adults. The disease may affect the jaw, central nervous system, bowel, kidneys, ovaries, or other organs. There are three main types of Burkitt lymphoma (sporadic, endemic, and immunodeficiency related). Sporadic Burkitt lymphoma occurs throughout the world, and endemic Burkitt lymphoma occurs in Africa. Immunodeficiency-related Burkitt lymphoma is most often seen in AIDS patients.

CSP Definition: form of undifferentiated malignant lymphoma usually found in central Africa, but also reported in other parts of the world; commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass; B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma; the Epstein-Barr virus (human herpesvirus 4) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases, however, most non-African cases are EBV-negative.

MSH Definition: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

Synonyms & Abbreviations: (see Synonym Details)
BL - Burkitt's lymphoma
BL
Burkitt Cell Leukemia
Burkitt Leukemia
Burkitt lymphoma (morphologic abnormality)
Burkitt Lymphoma [Disease/Finding]
Burkitt lymphoma, NOS
Burkitt lymphoma, unspecified site
Burkitt lymphoma
Burkitt tumor [obs]
Burkitt tumor
Burkitt tumour [obs]
Burkitt's Leukemia
Burkitt's lymphoma (clinical)
Burkitt's lymphoma (disorder)
Burkitt's lymphoma - disorder
Burkitt's lymphoma NOS
Burkitt's lymphomas
Burkitt's lymphoma
Burkitt's tumor [obs]
Burkitt's tumor or lymphoma
Burkitt's tumor
Burkitt's tumour [obs]
Burkitt's tumour or lymphoma
Burkitt's tumour
Burkitt's type malignant lymphoma - small non-cleaved
Burkitt's type malignant lymphoma - undifferentiated
Burkitts Leukemia
Burkitts Lymphoma
Burkitts Tumor
Cell Leukemia, Burkitt
L3 Lymphocytic Leukemias
L3 Lymphocytic Leukemia
Leukemia, Burkitt Cell
Leukemia, Burkitt's
Leukemia, Burkitt
Leukemia, L3 Lymphocytic
Leukemia, Lymphoblastic, Burkitt-Type
Leukemia, Lymphocytic, L3
Leukemias, L3 Lymphocytic
Lymphocytic Leukemia, L3
Lymphocytic Leukemias, L3
Lymphoma, Burkitt's
LYMPHOMA, BURKITT
Malignant lymphoma, Burkitt's type
Malignant lymphoma, small noncleaved, Burkitt type
Malignant lymphoma, small noncleaved, Burkitt's, diffuse
Malignant lymphoma, undifferentiated, Burkitt type [obs]
Malignant lymphoma, undifferentiated, Burkitt type
NHL, Burkitt's
non-Hodgkin's lymphoma, Burkitt's
Small Non-Cleaved Cell Lymphoma, Burkitt's Type
Tumor, Burkitt's
Tumor, Burkitt

External Source Codes: 
NCI Thesaurus Code C2912 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID B602. SNOMEDCT_US
CTV3ID BBq0. SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2004-6947 CSP
DISEASE_IDENTIFIER_ID 17628 GARD
DISEASE_IDENTIFIER_ID 17629 GARD
DX 19680101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 mature B-cell leukemia Burkitt type (C91.A-) ICD10CM
GENELOCUS ,8,q,2,4,.,1,2,-,q,2,4,.,1,3, OMIM
GENESYMBOL MYC OMIM
HAS_GARD_PAGE true GARD
HN 1998 (1968) MSH
IAN DEFAULT ICD10
ICD-O-3_Code 9687/3 NCI
ICD-O-3_CODE 9687/3 SNOMEDCT_US
ICE Malignant lymphoma, Burkitt's type ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM "Burkitt-like" lymphoma ICD10
INCLUSION_TERM Atypical Burkitt lymphoma ICD10
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative. NDFRT
MESH_DUI D002051 NDFRT
MESH_NAME Burkitt Lymphoma NDFRT
MESH_UI M0003058 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20150601 MSH
MN C02.256.466.313.165 MSH
MN C02.928.313.165 MSH
MN C04.557.386.480.150.165 MSH
MN C15.604.515.569.480.150.165 MSH
MN C20.683.515.761.480.150.165 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NUI N0000000633 NDFRT
OBS [obs] ICDO
ORDER_NO 02385 ICD10CM
ORDER_NO 02386 ICD10CM
PM 1998; see BURKITT'S LYMPHOMA 1968-1997; for LEUKEMIA, B-CELL, ACUTE & BURKITT LEUKEMIA see LEUKEMIA, B-CELL, ACUTE 1989-2007; for BURKITT TUMOR see BURKITT'S TUMOR 1968-1997; for LYMPHOMA, BURKITT see LYMPHOMA, BURKITT'S 1968-1997 MSH
PRIMARY_PATH 10006595$10006596$10025320$10029104$Burkitt's lymphoma$Burkitt's lymphomas$Lymphomas non-Hodgkin's B-cell$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5973/burkitt-lymphoma/resources/1 GARD
RXAUI 3119368 RXNORM
RXAUI 3119370 RXNORM
RXAUI 3119371 RXNORM
RXAUI 3119373 RXNORM
RXAUI 3119374 RXNORM
RXAUI 3190718 RXNORM
RXAUI 3286829 RXNORM
RXAUI 3286830 RXNORM
RXAUI 3286831 RXNORM
RXAUI 3287775 RXNORM
RXAUI 3287784 RXNORM
RXAUI 3287902 RXNORM
RXCUI 1024730 RXNORM
SEE_ALSO (see also M-9826/3) ICDO
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 16.0 MDR
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.0 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 118617000 NDFRT
SNOMED_CID 188509006 NDFRT
SNOMEDID DC-F0300 SNOMEDCT_US
SNOMEDID M-96873 SNOMEDCT_US
SOS includes all variants ICDO
SUBSET_MEMBER 446608001~MAPTARGET~9687/3 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS C83.7 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~C83.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS C83.70 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~C83.70 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~B602. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBq0. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DC-F0300 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~M-96873 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T005819 MSH
TERMUI T005820 MSH
TERMUI T005821 MSH
TERMUI T005822 MSH
TERMUI T005823 MSH
TERMUI T045624 MSH
TERMUI T045625 MSH
TERMUI T045628 MSH
TERMUI T045633 MSH
TERMUI T045634 MSH
TERMUI T684269 MSH
TH NLM (1968) MSH
TH NLM (1998) MSH
TH NLM (2008) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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