skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Bipolar Disorder (CUI C0005586) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0005586

NCI Thesaurus Code: C34423  (see NCI Thesaurus info)

Semantic Type: Mental or Behavioral Dysfunction

NCIt Definition: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

GARD Definition: Bipolar disorder is a type of mental illness that causes unusual shifts in mood, energy, activity levels, sleep and behavior. Signs and symptoms typically include alternating periods of manic episodes (joyful or excited states) and depressive episodes (very sad, hopeless or empty states). Mood episodes may also include symptoms of both mania and depression (a mixed state). It often develops in the late teens or early adult years, but age of onset can range from childhood to late in life. Bipolar disorder can run in families, although no single gene is thought to cause the condition. Many factors acting together likely increase a person's risk to develop the disorder. Treatment may include medication and psychotherapy for preventing relapses and reducing the severity of symptoms. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go from very happy, "up," and active to very sad and hopeless, "down," and inactive, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression.

The causes of bipolar disorder aren't always clear. It runs in families. Abnormal brain structure and function may also play a role.

Bipolar disorder often starts in a person's late teen or early adult years. But children and adults can have bipolar disorder too. The illness usually lasts a lifetime.

If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes.

If not treated, bipolar disorder can lead to damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments to control symptoms: medicine and talk therapy. A combination usually works best.

NIH: National Institute of Mental Health

MSH Definition: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Synonyms & Abbreviations: (see Synonym Details)
Affective Psychosis, Bipolar
Bi-polar Disorder
Bipolar affective disorder, unspecified
BIPOLAR AFFECTIVE DISORDER
bipolar affective psychosis
Bipolar disorder (disorder)
Bipolar Disorder [Disease/Finding]
Bipolar disorder NOS
Bipolar disorder, unspecified
Bipolar disorders
Bipolar Disorder
BIPOLAR DIS
Bipolar illness
BPAD
Disorder, Bipolar
Manic depression
manic depressive disorder
MANIC DEPRESSIVE ILLNESS
Manic depressive psychosis
MANIC DEPRESSIVE REACTION
Manic depressive
Manic-Depression
manic-depressive disorders
Manic-depressive illness
Manic-Depressive Psychoses
manic-depressive psychosis
Manic-depressive reaction NOS
Manic-depressive syndrome NOS
MDI - Manic-depressive illness
Psychoses, Bipolar Affective
Psychoses, Manic Depressive
Psychoses, Manic-Depressive
PSYCHOSIS MANIC-DEPRESSIVE
Psychosis, Bipolar Affective
Psychosis, Manic Depressive
Psychosis, Manic-Depressive
REACTION MANIC-DEPRESSIVE

External Source Codes: 
NCI Thesaurus Code C34423 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CO DG DH DI DT EC EH EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH SU TH UR VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID X00SM SNOMEDCT_US
DATE_CREATED 11/17/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2483-6684 CSP
DISEASE_IDENTIFIER_ID 21576 GARD
DISEASE_IDENTIFIER_ID 21577 GARD
DISEASE_IDENTIFIER_ID 21578 GARD
DISEASE_IDENTIFIER_ID 21579 GARD
DX 19810101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 bipolar disorder, single manic episode (F30.-) ICD10CM
EXCLUDES1 major depressive disorder, recurrent (F33.-) ICD10CM
EXCLUDES1 major depressive disorder, single episode (F32.-) ICD10CM
EXCLUDES2 cyclothymia (F34.0) ICD10CM
HAS_GARD_PAGE true GARD
HN 81(63) MSH
IAN DEFAULT ICD10
ICE Manic-depressive: {reaction NOS; syndrome NOS} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM manic-depressive: illness ICD10
INCLUSION_TERM manic-depressive: psychosis ICD10
INCLUSION_TERM manic-depressive: reaction ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. NDFRT
MESH_DUI D001714 NDFRT
MESH_NAME Bipolar Disorder NDFRT
MESH_UI M0002571 NDFRT
MMR 20150630 MSH
MN F03.084.500 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/bipolardisorder.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/bipolardisorder.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Mental Health http://www.nimh.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Bipolar Disorder NCI
NUI N0000000553 NDFRT
ORDER_NO 05422 ICD10CM
ORDER_NO 05455 ICD10CM
PM 81; see PSYCHOSES, MANIC-DEPRESSIVE 1963-80; see MANIC DISORDER 1984-97; for MANIC DISORDER see AFFECTIVE DISORDERS, PSYCHOTIC 1981-83 MSH
PRIMARY_PATH 10057667$10004938$10026753$10037175$Bipolar disorder$Bipolar disorders$Manic and bipolar mood disorders and disturbances$Psychiatric disorders MDR
PRIMARY_SOC 10037175 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10249/bipolar-disorder/resources/1 GARD
RXAUI 3107056 RXNORM
RXAUI 3117823 RXNORM
RXAUI 3117824 RXNORM
RXAUI 3196541 RXNORM
RXAUI 3225906 RXNORM
RXAUI 3225926 RXNORM
RXCUI 1022518 RXNORM
SID HP:0000755 HPO
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 13746004 NDFRT
SNOMED_CID 191646009 NDFRT
SNOMED_CID 191647000 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS F31.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~F31.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F31.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F31.9 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X00SM SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T004981 MSH
TERMUI T004982 MSH
TERMUI T004983 MSH
TERMUI T004984 MSH
TERMUI T004985 MSH
TH NLM (1966) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0005586

Mainbox Bottom