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Benzene (CUI C0005036) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0005036

NCI Thesaurus Code: C302  (see NCI Thesaurus info)

Semantic Type: Hazardous or Poisonous Substance

Semantic Type: Organic Chemical

NCIt Definition: A clear, colorless, highly flammable and volatile, liquid aromatic hydrocarbon with a gasoline-like odor. Benzene is found in crude oils and as a by-product of oil-refining processes. In industry benzene is used as a solvent, as a chemical intermediate, and is used in the synthesis of numerous chemicals. Exposure to this substance causes neurological symptoms and affects the bone marrow causing aplastic anemia, excessive bleeding and damage to the immune system. Benzene is a known human carcinogen and is linked to an increased risk of developing lymphatic and hematopoietic cancers, acute myelogenous leukemia, as well as chronic lymphocytic leukemia. (NCI05)

NCI-GLOSS Definition: A chemical that is used widely by the chemical industry, and is also found in tobacco smoke, vehicle emissions, and gasoline fumes. Exposure to benzene may increase the risk of developing leukemia.

CSP Definition: toxic, volatile, flammable liquid hydrocarbon biproduct of coal distillation; structure consists of a closed hexagonal chain of six carbon atoms, each attached to a hydrogen atom and attached to each other by alternating single and double (resonating) bonds; in benzene derivatives, one or more of the hydrogen atoms are replaced by other atoms or radicals.

MSH Definition: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

Synonyms & Abbreviations: (see Synonym Details)
Benzene (substance)
Benzene [Chemical/Ingredient]
benzene
Benzole
Benzol
Cyclohexatriene

External Source Codes: 
NCI Thesaurus Code C302 (see NCI Thesaurus info)
CAS Registry Number 71-43-2 (see NLM ChemIDplus info)
FDA UNII Code J64922108F
NSC Code 67315 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with benzil or benzal MSH
AQL AD AE AI AN CH CL CS CT EC HI IP ME PD PK PO RE SD ST TO TU MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHEBI_ID CHEBI:16716 NCI
Chemical_Formula C6H6 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID X808z SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0390-1459 CSP
DX 19660101 MSH
EC analogs & derivatives:Benzene Derivatives MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE J64922108F NDFRT
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide. NDFRT
MESH_DUI D001554 NDFRT
MESH_NAME Benzene NDFRT
MESH_UI M0002332 NDFRT
MMR 20130708 MSH
MN D02.455.426.559.389.023 MSH
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000166410 NDFRT
NUI N0000182445 NDFRT
RN J64922108F MSH
RR 71-43-2 (Benzene) MSH
RXAUI 3117029 RXNORM
RXAUI 3117033 RXNORM
RXAUI 3117327 RXNORM
RXAUI 3117330 RXNORM
RXAUI 3136815 RXNORM
RXAUI 3627901 RXNORM
RXAUI 3630981 RXNORM
RXAUI 3634028 RXNORM
RXAUI 3634029 RXNORM
RXAUI 5461292 RXNORM
RXCUI 1311295 RXNORM
SOS A toxic, volatile hydrocarbon derived mainly from the carbonization of coal; prolonged inhalation will result in acute poisoning. It is used extensively in the petroleum, plastic, explosives, and pesticide industries and is most commonly found in gasoline, rubber cement, and paint and varnish removers. Most countries legally regulate the allowable exposure and concentration of fumes in its industrial use as a solvent because of its ability to produce leukemia and severe anemias. It is also called benzol. Methyl benzene is known as toluene. AOD
SOS Classification: volatile inhalants. See also naphtha. AOD
SPL_SET_ID 0266bb0b-0e7a-4e00-8321-9bfe7c6ed7fa MTHSPL
SPL_SET_ID 134d1cc1-2300-409d-b562-98ce807e77b3 MTHSPL
SPL_SET_ID 15209393-be72-449c-bd37-b2feaffed70b MTHSPL
SPL_SET_ID 3bdf63e1-9bd5-4f26-8baf-7abc0885a2d3 MTHSPL
SPL_SET_ID 4c130208-8e8a-46aa-bd2a-6ddc6afbb8ac MTHSPL
SPL_SET_ID 4e9f9d7a-f927-4d39-8b87-a0aeb1199075 MTHSPL
SPL_SET_ID 54697992-54ea-4cd3-9d8d-1fe1a5709076 MTHSPL
SPL_SET_ID 57bc618b-15bd-4d04-8037-fb192e743e30 MTHSPL
SPL_SET_ID 64655edd-9f91-4278-af1e-01a8461daf0f MTHSPL
SPL_SET_ID 72ccb9be-2d62-414a-856a-7fcea51f26d2 MTHSPL
SPL_SET_ID 79faee5a-0a31-47a6-b222-2d6f1f271a5f MTHSPL
SPL_SET_ID 7cf929f0-35da-4453-92e1-36c309d14975 MTHSPL
SPL_SET_ID 87c7058f-9fd8-4807-a2aa-3632d8a56c49 MTHSPL
SPL_SET_ID 9877c002-a304-4215-b555-bab87c93903f MTHSPL
SPL_SET_ID 98a7ca26-ccb7-43c7-bd65-892fcbacc882 MTHSPL
SPL_SET_ID cbcee894-b0f2-40a8-8d26-59c4ea56fd1f MTHSPL
SPL_SET_ID d5a8acca-087f-43e2-b0a2-c9df36f625a9 MTHSPL
SPL_SET_ID e5c39e72-2eae-4e41-bfff-6afb1dbb9293 MTHSPL
SPL_SET_ID f13f0a0c-a795-46b5-ac68-15225895090c MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~X808z SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T004500 MSH
TERMUI T004501 MSH
TERMUI T004502 MSH
TERMUI T004503 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH NLM (1996) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4735^Active/Master NDFRT
VUID 4030490 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0005036

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